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of 168
pro vyhledávání: '"Helen C. O'Neill"'
Autor:
Helen C. O’Neill, Hong Kiat Lim
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
In bone marrow, the niche which supports hematopoiesis and nurtures hematopoietic stem cells (HSCs) contains perivascular reticular cells representing a subset of skeletal stem/progenitor cells (SSPCs). These stromal cells which provide the niche are
Externí odkaz:
https://doaj.org/article/9be303faa20f41f6aa4b2f0f18a405a1
Autor:
Veronica Pini, Virginie Mariot, Julie Dumonceaux, John Counsell, Helen C. O’Neill, Sarah Farmer, Francesco Conti, Francesco Muntoni
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Among the mutations arising in the DMD gene and causing Duchenne Muscular Dystrophy (DMD), 10–15% are multi-exon duplications. There are no current therapeutic approaches with the ability to excise large multi-exon duplications, leaving th
Externí odkaz:
https://doaj.org/article/f9737f98c68e4dc1b4e5032db9cf3319
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract Age-related macular degeneration (AMD) is a highly prevalent form of blindness caused by loss death of cells of the retinal pigment epithelium (RPE). Transplantation of pluripotent stem cell (PSC)-derived RPE cells is considered a promising
Externí odkaz:
https://doaj.org/article/e5817df1a6d74ac0b9e504f54e8e88b0
Autor:
Vinson Tran, Helen C. O’Neill
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Study of the microenvironment that supports hematopoietic stem cell (HSC) development in vivo is very difficult involving small numbers of interacting cells which are usually not well defined. While much is known about HSC niches located within the b
Externí odkaz:
https://doaj.org/article/477c9700d56a43f3bb0deb2cba910f01
Publikováno v:
BMC Immunology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations o
Externí odkaz:
https://doaj.org/article/5b451c195bd048928abf97330fd5f04f
Autor:
Hong Kiat Lim, Helen C. O’Neill
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses. This study has used phenotypic information of a previously described spleen stromal cell lin
Externí odkaz:
https://doaj.org/article/747b852bee43458cafb0989a2d2a9773
Publikováno v:
Stem Cells International, Vol 2018 (2018)
There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen s
Externí odkaz:
https://doaj.org/article/fafef5dc65604356966fc9188a6b048d
Autor:
Keping Ni, Helen C. O'Neill
Publikováno v:
Clinical and Developmental Immunology, Vol 8, Iss 2, Pp 133-146 (2001)
Externí odkaz:
https://doaj.org/article/3f07acf957ac4f788fc1af5305acb6dd
Autor:
Helen C. O'Neill, Kristin L. Griffiths, Pravin Periasamy, Rebecca A. Hinton, Ying-Ying Hey, Sawang Petvises, Jonathan K. H. Tan
Publikováno v:
Stem Cells International, Vol 2011 (2011)
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvir
Externí odkaz:
https://doaj.org/article/6b22e2df20b5463eb11176df2955f6cd
Publikováno v:
F&S Science. 4:17-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6bb15b2d1d687eb6c800e3dc7004652
https://doi.org/10.1016/j.xfss.2023.03.004
https://doi.org/10.1016/j.xfss.2023.03.004