Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Helen C. Miranda"'
Autor:
Ian Matthews, Allison Birnbaum, Anastasia Gromova, Amy W. Huang, Kailin Liu, Eleanor A. Liu, Kristen Coutinho, Megan McGraw, Dalton C. Patterson, Macy T. Banks, Amber C. Nobles, Nhat Nguyen, Gennifer E. Merrihew, Lu Wang, Eric Baeuerle, Elizabeth Fernandez, Nicolas Musi, Michael J. MacCoss, Helen C. Miranda, Albert R. La Spada, Constanza J. Cortes
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113436- (2023)
Summary: Skeletal muscle has recently arisen as a regulator of central nervous system (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here, we repor
Externí odkaz:
https://doaj.org/article/1587bf560e50423e9bbcf4e8794e369a
Publikováno v:
Semin Cell Dev Biol
The translation of information encoded in the DNA into functional proteins is one of the tenets of cellular biology. Cell survival and function depend on the tightly controlled processes of transcription and translation. Growing evidence suggests tha
Autor:
Ian Matthews, Allison Birnbaum, Anastasia Gromova, Kristen Coutinho, Megan McGraw, Dalton Patterson, Macy T. Banks, Amber Nobles, Nhat Nguyen, Helen C. Miranda, Albert R. La Spada, Constanza J. Cortes
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with proteostasis and metabolism-modifying functions in targeted tissues, including the CNS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb167b37a83f65cecb3ffb8321454bb8
https://doi.org/10.21203/rs.3.rs-1578234/v1
https://doi.org/10.21203/rs.3.rs-1578234/v1
Paracrine signaling is challenging to study in vitro, as conventional culture tools dilute soluble factors and offer little to no spatiotemporal control over signaling. Microfluidic chips offer potential to address both of these issues. However, few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3753b2fb456c0bd74977b997ab307955
https://doi.org/10.1101/2022.03.25.485382
https://doi.org/10.1101/2022.03.25.485382
Autor:
Ian Matthews, Allison Birnbaum, Anastasia Gromova, Kristen Coutinho, Megan McGraw, Dalton C. Patterson, Macy T. Banks, Amber Nobles, Nhat Nguyen, Helen C. Miranda, Albert R. La Spada, Constanza J. Cortes
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with proteostasis and metabolism-modifying functions in targeted tissues, including the CNS.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea6ca6cf19e6a05a321897e80d9ced42
https://doi.org/10.1101/2022.03.07.482891
https://doi.org/10.1101/2022.03.07.482891
Autor:
Tiffany W Todd, Hiroshi Kokubu, Helen C Miranda, Constanza J Cortes, Albert R La Spada, Janghoo Lim
Publikováno v:
eLife, Vol 4 (2015)
Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular disease caused by polyglutamine expansion in the androgen receptor (AR) protein. Despite extensive research, the exact pathogenic mechanisms underlying SBMA remain elusive. In t
Externí odkaz:
https://doaj.org/article/cc43d13fc78744b6a1f713f365da0625
Autor:
Geneva R. LaForce, Jordan S. Farr, Jingyi Liu, Cydni Akesson, Evren Gumus, Otis Pinkard, Helen C. Miranda, Katherine Johnson, Thomas J. Sweet, Ping Ji, Ai Lin, Jeff Coller, Polyxeni Philippidou, Eric J. Wagner, Ashleigh E. Schaffer
Publikováno v:
Neuron
Tight regulation of mRNA isoform expression is essential for neuronal development, maintenance, and function; however, the repertoire of proteins that govern isoform composition and abundance remains incomplete. Here, we show that the RNA kinase CLP1
Autor:
Baochang Fan, Yimei Li, Brett J. Winborn, J. Paul Taylor, Emmanuelle R. Quemin, Jennifer Moore, Rebecca B. Smith, Helen C. Miranda, Burgess B. Freeman, Jennifer Dearman, Ane Korff, Hong Joo Kim, Pradeep K. Vuppala, Heather Tillman, James Messing, Brian D. Freibaum, Ping-Chung Chen, Albert R. La Spada, Nam Chul Kim, Anderson P. Kanagaraj, Bryce L. Sopher, Yingzhe Wang, Nisha M. Badders
Publikováno v:
Nature Medicine. 24:427-437
Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by toxic gain of function of the androgen receptor (AR). Previously, we found that co-regulator binding through the activation function-2 (AF2) domain of AR is essential for patho