Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Helen C, Turner"'
Autor:
Leah Nemzow, Michelle A. Phillippi, Karthik Kanagaraj, Igor Shuryak, Maria Taveras, Xuefeng Wu, Helen C. Turner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Following a large-scale radiological event, timely collection of samples from all potentially exposed individuals may be precluded, and high-throughput bioassays capable of rapid and individualized dose assessment several days post-exposure
Externí odkaz:
https://doaj.org/article/a8975adcf3bc4a2caaaedcb41afd7fd5
Autor:
Karthik Kanagaraj, Michelle A. Phillippi, Elizabeth H. Ober, Igor Shuryak, Norman J. Kleiman, John Olson, George Schaaf, J. Mark Cline, Helen C. Turner
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract There are currently no available FDA-cleared biodosimetry tools for rapid and accurate assessment of absorbed radiation dose following a radiation/nuclear incident. Previously we developed a protein biomarker-based FAST-DOSE bioassay system
Externí odkaz:
https://doaj.org/article/54ce1567c9eb483a953a551bb96d2cf9
Autor:
Leah Nemzow, Thomas Boehringer, Jessica Mayenburg, Lindsay A Beaton-Green, Ruth C Wilkins, Helen C Turner
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301418 (2024)
In the event of a widespread radiological incident, thousands of individuals will require rapid assessment of exposure using validated biodosimetry assays to inform clinical triage. In this scenario, multiple biodosimetry laboratories may be necessar
Externí odkaz:
https://doaj.org/article/cc49e18d91b34f2598b1d8e646f7f299
Autor:
Shanaz A. Ghandhi, Shad R. Morton, Igor Shuryak, Younghyun Lee, Rajesh K. Soni, Jay R. Perrier, James Bakke, Janet Gahagan, Kim Bujold, Simon Authier, Sally A. Amundson, David J. Brenner, Denise Nishita, Polly Chang, Helen C. Turner
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-21 (2023)
Abstract Background Non-human primates, such as Rhesus macaques, are a powerful model for studies of the cellular and physiological effects of radiation, development of radiation biodosimetry, and for understanding the impact of radiation on human he
Externí odkaz:
https://doaj.org/article/e3eec020d628404887323c5ef5dd4b5f
Autor:
Igor Shuryak, Leah Nemzow, Bezalel A. Bacon, Maria Taveras, Xuefeng Wu, Naresh Deoli, Brian Ponnaiya, Guy Garty, David J. Brenner, Helen C. Turner
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract During a large-scale radiological event such as an improvised nuclear device detonation, many survivors will be shielded from radiation by environmental objects, and experience only partial-body irradiation (PBI), which has different consequ
Externí odkaz:
https://doaj.org/article/132213d2e1ce4c8a8ca0f85f20fbfa9b
Autor:
Igor Shuryak, Ekaterina Royba, Mikhail Repin, Helen C. Turner, Guy Garty, Naresh Deoli, David J. Brenner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract A large-scale malicious or accidental radiological event can expose vast numbers of people to ionizing radiation. The dicentric chromosome (DCA) and cytokinesis-block micronucleus (CBMN) assays are well-established biodosimetry methods for e
Externí odkaz:
https://doaj.org/article/1a15af263c514e6d8d0c2477e6a4ca66
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0289634 (2023)
In the event of a widespread radiological incident, thousands of people may be exposed to a wide range of ionizing radiation. In this unfortunate scenario, there will be a need to quickly screen a large number of people to assess the amount of radiat
Externí odkaz:
https://doaj.org/article/75d4d716686546cc8c11fc667856a114
Autor:
Igor Shuryak, Helen C. Turner, Monica Pujol-Canadell, Jay R. Perrier, Guy Garty, David J. Brenner
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract We implemented machine learning in the radiation biodosimetry field to quantitatively reconstruct neutron doses in mixed neutron + photon exposures, which are expected in improvised nuclear device detonations. Such individualized reconstruct
Externí odkaz:
https://doaj.org/article/35230253caf340c5a876ae1e78980dac
Publikováno v:
Radiation Oncology, Vol 14, Iss 1, Pp 1-10 (2019)
Abstract Background Measurement of γ-H2AX foci levels in cells provides a sensitive and reliable method for quantitation of the radiation-induced DNA damage response. The objective of the present study was to develop a rapid, high-throughput γ-H2AX
Externí odkaz:
https://doaj.org/article/2e3181759daa4be1a3fa693ad277afa2
Autor:
Helen C. Turner, Younghyun Lee, Waylon Weber, Dunstana Melo, Aimee Kowell, Shanaz A. Ghandhi, Sally A. Amundson, David J. Brenner, Igor Shuryak
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Cesium-137 (137Cs) is one of the major and most clinically relevant radionuclides of concern in a radiological dispersal device, “dirty bomb” scenario as well as in nuclear accidents and detonations. In this exposure scenario,
Externí odkaz:
https://doaj.org/article/86307833fc74485689146659fb8baf65