Zobrazeno 1 - 10 of 78 pro vyhledávání: '"Helen Blanchard"'
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Akademický článek
Role of pentraxin 3 in shaping arthritogenic alphaviral disease: from enhanced viral replication to immunomodulation.
Autor: Suan-Sin Foo, Weiqiang Chen, Adam Taylor, Kuo-Ching Sheng, Xing Yu, Terk-Shin Teng, Patrick C Reading, Helen Blanchard, Cecilia Garlanda, Alberto Mantovani, Lisa F P Ng, Lara J Herrero, Suresh Mahalingam
Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004649 (2015)
The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic. The immune responses un
Externí odkaz: https://doaj.org/article/6838dd42999d48539a22559e59a65ae3
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3
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia
Autor: Khuchtumur Bum-Erdene, Patrick M. Collins, Matthew W. Hugo, Somayeh S. Tarighat, Fei Fei, Chandan Kishor, Hakon Leffler, Ulf. J. Nilsson, John Groffen, I. Darren Grice, Nora Heisterkamp, Helen Blanchard
Publikováno v: Journal of medicinal chemistry. 65(8)
Galectin-3 is a β-galactoside-specific, carbohydrate-recognizing protein (lectin) that is strongly implicated in cancer development, metastasis, and drug resistance. Galectin-3 promotes migration and ability to withstand drug treatment of B-cell pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7188e76c0e841f4328e005b80235cd2
https://pubmed.ncbi.nlm.nih.gov/35427125
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4
Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8N Antagonists
Autor: Hadas Shatz-Azoulay, Yaron Vinik, Yehiel Zick, Todd Ashley Houston, Brijesh Patel, Chandan Kishor, Helen Blanchard
Publikováno v: Journal of Medicinal Chemistry. 63:11573-11584
Galectin-8 is a β-galactoside-recognizing protein having an important role in the regulation of bone remodeling and cancer progression and metastasis. Methyl β-d-galactopyranoside malonyl aromatic esters have been designed to target and engage with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce0f4ac6f5bc9df530df85ca01b275e0
https://doi.org/10.1021/acs.jmedchem.0c00602
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5
Investigation of the Molecular Details of the Interactions of Selenoglycosides and Human Galectin-3
Autor: Fehér, Mária Raics, Álex Kálmán Balogh, Chandan Kishor, István Timári, Francisco J. Medrano, Antonio Romero, Rob Marc Go, Helen Blanchard, László Szilágyi, Katalin E. Kövér, Krisztina
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2494
Human galectin-3 (hGal-3) is involved in a variety of biological processes and is implicated in wide range of diseases. As a result, targeting hGal-3 for clinical applications has become an intense area of research. As a step towards the development
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::b57105fd27f3d0a537e0e837922c21d7
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7
Overcoming Microenvironment-Mediated Chemoprotection through Stromal Galectin-3 Inhibition in Acute Lymphoblastic Leukemia
Autor: Eun Ji Joo, I. Darren Grice, Mark von Itzstein, Hisham Abdel-Azim, Khuchtumur Bum-Erdene, Nora Heisterkamp, Lu Yang, Huimin Geng, Helen Blanchard, Somayeh S. Tarighat, Fei Fei
Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12167, p 12167 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22
International journal of molecular sciences, vol 22, iss 22
Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7729abf9cc18a02056feae30e45ccbe
https://www.mdpi.com/1422-0067/22/22/12167
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8
Overcoming microenvironment-mediated chemoprotection through stromal galectin-3 inhibition in acute lymphoblastic leukemia
Autor: Lu Yang, N. Heisterkamp, Somayeh S. Tarighat, Helen Blanchard, M. von Itzstein, Fei Fei, Eun Ji Joo, Khuchtumur Bum-Erdene, Huimin Geng, Darren Grice, Hisham Abdel-Azim
Environmentally-mediated drug resistance in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) significantly contributes to relapse. Stromal cells in the bone marrow environment protect leukemia cells by secretion of chemokines as cues for BCP-A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bd690a2d03afaad4f03667df5a600dd
https://doi.org/10.1101/2021.09.24.461149
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10
Rational Design and Synthesis of Methyl-β-d-galactomalonyl Phenyl Esters as Potent Galectin-8
Autor: Brijesh, Patel, Chandan, Kishor, Todd A, Houston, Hadas, Shatz-Azoulay, Yehiel, Zick, Yaron, Vinik, Helen, Blanchard
Publikováno v: Journal of medicinal chemistry. 63(20)
Galectin-8 is a β-galactoside-recognizing protein having an important role in the regulation of bone remodeling and cancer progression and metastasis. Methyl β-d-galactopyranoside malonyl aromatic esters have been designed to target and engage with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f08e253d90c996ded5116778a0f9687
https://pubmed.ncbi.nlm.nih.gov/32809817
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