Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Helen Berke"'
Autor:
Kevin M. Walton, Jeff Ohren, John D. Knafels, Amy Rosado, Travis T. Wager, Butler Todd W, Andy N. Mead, Blossom Sneed, Katherine Fisher, David Horton, Shenping Liu, George J DeMarco, Scot Richard Mente, Helen Berke, Angela C. Doran, Cheng Chang, Jenifer Bradley, Michael Marconi, Ramalakshmi Yegna Chandrasekaran, David M. Rubitski
Publikováno v:
ACS chemical neuroscience. 5(12)
Casein kinase 1 delta (CK1δ) and casein kinase 1 epsilon (CK1ε) inhibitors are potential therapeutic agents for a range of psychiatric disorders. The feasibility of developing a CNS kinase inhibitor has been limited by an inability to identify safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a7208458ec1fdafc42a2636101dc09
https://pubmed.ncbi.nlm.nih.gov/25299732
https://pubmed.ncbi.nlm.nih.gov/25299732
Autor:
Kelvin Cooper, Karen W. Hoover, Christine A. Kennedy, Wester Ronald Thure, Michael L. Mangiapane, Donald L. Bussolotti, Helen Berke, Mularski Christian J, Paul Da Silva Jardine, Albert L. Rauch, Janet A. LaFlamme, Philip A. Carpino, Michael Burkard, Charles E. Aldinger, George T. Magnus-Ayritey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:133-138
The syntheses and biological activities of dihydropyridine angiotensin II (AII) antagonists are described. Compounds such as 12 are examples of a new, structurally distinct class of AT(in1-selective agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef80cfada0f40be71605d888f8d48bb2
https://doi.org/10.1016/s0960-894x(01)81135-5
https://doi.org/10.1016/s0960-894x(01)81135-5
Autor:
Charles E. Aldinger, Michael Burkard, C. A. Kennedy, R. T. Wester, K. Cooper, Michael L. Mangiapane, Donald L. Bussolotti, Helen Berke, P. Da Silva Jardine, A. L. Rauch, K. W. Hoover, C. J. Mularski, G. T. Magnus‐Ayritey, Philip A. Carpino, Janet A. LaFlamme
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a654b73de627e347b8aeb2aec4d4175
https://doi.org/10.1002/chin.199426177
https://doi.org/10.1002/chin.199426177
Autor:
Bruce N. Rogers, Lei Zhang, Weimin Qian, Alan H. Ganong, John Candler, Allen J. Duplantier, Angela C. Doran, Helen Berke, Andy Q. Zhang, Stanley F. McHardy, John T. Lazzaro, Ivan Viktorovich Efremov, Noha Maklad
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(20)
The synthesis and structure–activity relationship (SAR) of a novel series of 3-(imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers, derived from a high throughput screening (HTS), are described. Subsequent optimization led to identific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c2926e12cc5a6c438c63b040f7e927
https://pubmed.ncbi.nlm.nih.gov/18812259
https://pubmed.ncbi.nlm.nih.gov/18812259
Autor:
Joseph G. Lombardino, Earl B. Whipple, Braisted Andrew Charles, Helen Berke, Jon Bordner, Philip D. Hammen
Publikováno v:
Journal of Heterocyclic Chemistry. 26:11-16
Alkylation of piroxicam with a homologous series of alkyl iodides gave reversibly formed O-alkyl products 1 as well as unexpected, irreversibly formed zwitterionic compounds 2, alkylated on the pyridine nitrogen, and O,N-bis-alkyl products 3. Proof o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b97bdf9299ebdddf32793f377548ea8
https://doi.org/10.1002/jhet.5570260103
https://doi.org/10.1002/jhet.5570260103
Publikováno v:
Journal of Heterocyclic Chemistry. 22:837-840
A novel compound, spiro[(2,3-dihydro-2-oxo-imidazo[1,2-a]pyridine)-3,3-(3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine 1,1-dioxide)] (3), was isolated during an attempt to convert 4-hydroxy-2-methyl-N-(2-pyridinyl)-2H-1,2-benzothiazine-3-carboxamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9088c31b192a8e43f4f855625e69b2a5
https://doi.org/10.1002/jhet.5570220346
https://doi.org/10.1002/jhet.5570220346
Autor:
Joseph G. Lombardino, Earl B. Whipple, Jon Bordner, Braisted Andrew Charles, Philip D. Hammen, Helen Berke
Publikováno v:
ChemInform. 20
Alkylation of piroxicam with a homologous series of alkyl iodides gave reversibly formed O-alkyl products 1 as well as unexpected, irreversibly formed zwitterionic compounds 2, alkylated on the pyridine nitrogen, and O,N-bis-alkyl products 3. Proof o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc479d6280a7a95cbaeccdef586cdbe
https://doi.org/10.1002/chin.198934242
https://doi.org/10.1002/chin.198934242
Publikováno v:
Chemischer Informationsdienst. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf97e13109f4ebbeedfb98e2be439a4c
https://doi.org/10.1002/chin.198603240
https://doi.org/10.1002/chin.198603240