Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Helen Bardwell"'
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Autor:
Jennifer L. Caswell-Jin, Katherine McNamara, Johannes G. Reiter, Ruping Sun, Zheng Hu, Zhicheng Ma, Jie Ding, Carlos J. Suarez, Susanne Tilk, Akshara Raghavendra, Victoria Forte, Suet-Feung Chin, Helen Bardwell, Elena Provenzano, Carlos Caldas, Julie Lang, Robert West, Debu Tripathy, Michael F. Press, Christina Curtis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
When examining the evolution of treatment resistance in breast cancer, perceived genomic changes may be due to clonal evolution or heterogeneous tumors. Here, the authors show that apparent clonal change can in fact be due to pre-treatment heterogene
Externí odkaz:
https://doaj.org/article/3b5c30a996d54c2086cfff5a285a1014
Autor:
Jennifer L. Caswell-Jin, Katherine McNamara, Johannes G. Reiter, Ruping Sun, Zheng Hu, Zhicheng Ma, Jie Ding, Carlos J. Suarez, Susanne Tilk, Akshara Raghavendra, Victoria Forte, Suet-Feung Chin, Helen Bardwell, Elena Provenzano, Carlos Caldas, Julie Lang, Robert West, Debu Tripathy, Michael F. Press, Christina Curtis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article omitted from the Author Contributions statement that ‘R.S. and J.G.R contributed equally to this work.’ This has been corrected in both the PDF and HTML versions of the Article.
Externí odkaz:
https://doaj.org/article/b021138f6e9b4cb1925f14aab5f161ba
Autor:
Abigail Shea, Yaniv Eyal-Lubling, Daniel Guerrero-Romero, Raquel Manzano Garcia, Wendy Greenwood, Martin O’Reilly, Dimitra Georgopoulou, Maurizio Callari, Giulia Lerda, Sophia Wix, Agnese Giovannetti, Riccardo Masina, Elham Esmaeilishirazifard, Alistair G. Martin, Ai Nagano, Lisa Young, Steven Kupczak, Yi Cheng, Helen Bardwell, Elena Provenzano, Justine Kane, Jonny Lay, Louise Grybowicz, Karen McAdam, Carlos Caldas, Jean Abraham, Oscar M Rueda, Alejandra Bruna
Triple negative breast cancers (TNBC) exhibit inter- and intra-tumour heterogeneity, which is reflected in diverse drug responses and interplays with tumour evolution. Here, we use TNBC patient-derived tumour xenografts (PDTX) as a platform for co-cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cad7c88a021ecd7f54db81a5cd21421
https://doi.org/10.1101/2023.01.10.523259
https://doi.org/10.1101/2023.01.10.523259
Autor:
Katherine McNamara, Ruping Sun, S-F Chin, Je Lang, Helen Bardwell, Debu Tripathy, Michael F. Press, Akshara Singareeka Raghavendra, Victoria Forte, Johannes G. Reiter, Carlos Suárez, Zheng Hu, Elena Provenzano, Robert B. West, Christina Curtis, Susanne Tilk, C Caldas, Jennifer L. Caswell-Jin, Zhicheng Ma
Publikováno v:
Cancer Research. 79:P3-06
Background: Understanding to what extent a breast tumor's genetic composition may change over the course of a few months of neoadjuvant therapy has implications for optimal therapeutic approach. However, genomic changes observed across treatment may
Clonal replacement and heterogeneity in breast tumors treated with neoadjuvant HER2-targeted therapy
Autor:
Jie Ding, Ruping Sun, Helen Bardwell, Suet-Feung Chin, Akshara Singareeka Raghavendra, Michael F. Press, Johannes G. Reiter, Carlos Suárez, Jennifer L. Caswell-Jin, Robert B. West, Zheng Hu, Debasish Tripathy, Carlos Caldas, Christina Curtis, Zhicheng Ma, Katherine McNamara, Elena Provenzano, Julie E. Lang, Susanne Tilk, Victoria Forte
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Genomic changes observed across treatment may result from either clonal evolution or geographically disparate sampling of heterogeneous tumors. Here we use computational modeling based on analysis of fifteen primary breast tumors and find that appare
Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer
Autor:
H Raza, Ali, Hartland W, Jackson, Vito R T, Zanotelli, Esther, Danenberg, Jana R, Fischer, Helen, Bardwell, Elena, Provenzano, Oscar M, Rueda, Suet-Feung, Chin, Samuel, Aparicio, Carlos, Caldas, X, Zhuang
Publikováno v:
Nature cancer. 1(2)
Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly defined ways. To investigate these relationships, we used imaging mass cytometry to quantify the expression of 37 proteins with subcellular spatial resolution i
Autor:
Elena Provenzano, Akshara Singareeka Raghavendra, Debu Tripathy, Carlos Suárez, Jie Ding, Ruping Sun, Helen Bardwell, Jennifer L. Caswell-Jin, Johannes G. Reiter, Robert B. West, Zhicheng Ma, Zheng Hu, Christina Curtis, Suet-Feung Chin, Julie E. Lang, Susanne Tilk, Katherine McNamara, Victoria Forte, Carlos Caldas, Michael F. Press
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article omitted from the Author Contributions statement that ‘R.S. and J.G.R contributed equally to this work.’ This has been corrected in both the PDF and HTML versions of the Article.
Autor:
Eun Yoon Cho, Mae A. Goldgraben, Elena Provenzano, Angela Santoja, Harry Clifford, Soomin Ahn, Emilio Alba, Federico Rojo, Marta Grzelak, Helen Bardwell, Carlos Caldas, Oscar M. Rueda, Stephen John Sammut, Suet-Feung Chin, Michelle Pugh
Publikováno v:
Experimental and Molecular Pathology
Pathology archives with linked clinical data are an invaluable resource for translational research, with the limitation that most cancer samples are formalin-fixed paraffin-embedded (FFPE) tissues. Therefore, FFPE tissues are an important resource fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b0d133e1720832d8130a43904a3325
Autor:
Louise Walsh, Bo Li, John Crown, Karin Jirström, Helen Bardwell, Alexander Gaber, Yue Fan, Thierry Dubois, Suet-Feung Chin, Carlos Caldas, Stephen F. Madden, Elena Provenzano, Aisling O'Connor, Sabine C. Linn, Gillian O'Hurley, Girish Mallya Udupi, Triona Ni Chonghaile, William M. Gallagher, Jesuchristopher Joseph, Darran P. O'Connor, Emer Conroy, Finbarr Tarrant, Rut Klinger
Publikováno v:
Cancer Research, 77(14), 3834. American Association for Cancer Research Inc.
Triple-negative breast cancer (TNBC) patients commonly exhibit poor prognosis and high relapse after treatment, but there remains a lack of biomarkers and effective targeted therapies for this disease. Here, we report evidence highlighting the cell-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a467fd772b6b0c675614209f3d89c0
https://dspace.library.uu.nl/handle/1874/355880
https://dspace.library.uu.nl/handle/1874/355880
Autor:
Roslin Russell, Suet-Feung Chin, Stephen John Sammut, Sarah-Jane Dawson, Anne Lise Børresen-Dale, David R. Bentley, Helen Bardwell, Oscar M. Rueda, Hans Kristian Moen Vollan, Michelle Pugh, Carlos Caldas, Abhik Mukherjee, Ian O. Ellis, Arnie Purushotham, Sohrab P. Shah, Helena M. Earl, Paul D.P. Pharoah, Andrew R. Green, Helen Northen, Samuel Aparicio, Bernard Pereira, Bin Liu, Gulisa Turashvili, Arusha Oloumi, Sarah E Pinder, Leigh C. Murphy, Nitzan Rosenfeld, Linda Jones, Dana W.Y. Tsui, John F. Peden, Mark T. Ross, Jean Abraham, Steve McKinney, Elena Provenzano
Publikováno v:
Pereira, B, Chin, S F, Rueda, O M, Vollan, H K M, Provenzano, E, Bardwell, H A, Pugh, M, Jones, L, Russell, R, Sammut, S J, Tsui, D W Y, Liu, B, Dawson, S J, Abraham, J, Northen, H, Peden, J F, Mukherjee, A, Turashvili, G, Green, A R, McKinney, S, Oloumi, A, Shah, S, Rosenfeld, N, Murphy, L, Bentley, D R, Ellis, I O, Purushotham, A, Pinder, S E, BØrresen-Dale, A L, Earl, H M, Pharoah, P D, Ross, M T, Aparicio, S & Caldas, C 2016, ' The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes ', Nature Communications, vol. 7, no. 1, 11479 . https://doi.org/10.1038/ncomms11479
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have copy number aberration (CNA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85213040995b9895564615566c9fe80c
http://eprints.nottingham.ac.uk/37693/
http://eprints.nottingham.ac.uk/37693/