Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Helen B Forrester"'
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173788 (2017)
PURPOSE:Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment. The activins, proteins which are members of the TGFβ superfamily, have a major role in stimu
Externí odkaz:
https://doaj.org/article/03f775f04c3846ce9eef5b92b44c7699
Autor:
Helen B Forrester, Alesia Ivashkevich, Michael J McKay, Trevor Leong, David M de Kretser, Carl N Sprung
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77119 (2013)
Follistatin is a potent regulator of the inflammatory response and binds to and inhibits activin A action. Activin A is a member of the TGFβ protein superfamily which has regulatory roles in the inflammatory response and in the fibrotic process. Fib
Externí odkaz:
https://doaj.org/article/a543d001501c4ba980f876a7a1484090
Autor:
Helen B Forrester, Peter Temple-Smith, Seungmin Ham, David de Kretser, Graeme Southwick, Carl N Sprung
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59056 (2013)
Dupuytren's disease (DD) is a classic example of pathological fibrosis which results in a debilitating disorder affecting a large sector of the human population. It is characterized by excessive local proliferation of fibroblasts and over-production
Externí odkaz:
https://doaj.org/article/6b7ddbeab9384750af47ddf09ab37e1a
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53358 (2012)
DNA repair is an essential cellular process required to maintain genomic stability. Every cell is subjected to thousands of DNA lesions daily under normal physiological conditions. Ionizing radiation (IR) is a major DNA damaging agent that can be pro
Externí odkaz:
https://doaj.org/article/a4c734f8fc874654be947dc320d320a5
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25758 (2011)
Humans are exposed to the DNA damaging agent, ionizing radiation (IR), from background radiation, medical treatments, occupational and accidental exposures. IR causes changes in transcription, but little is known about alternative transcription in re
Externí odkaz:
https://doaj.org/article/618d75e3c9ec4d72836d6d2414cb24a0
Autor:
Pavel Lobachevsky, Helen B. Forrester, Alesia Ivashkevich, Joel Mason, Andrew W. Stevenson, Chris J. Hall, Carl N. Sprung, Valentin G. Djonov, Olga A. Martin
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Synchrotron radiation, especially microbeam radiotherapy (MRT), has a great potential to improve cancer radiotherapy, but non-targeted effects of synchrotron radiation have not yet been sufficiently explored. We have previously demonstrated that scat
Externí odkaz:
https://doaj.org/article/7134005c3d1e4eff8f6c4f102083903a
Autor:
Lloyd M. L. Smyth, Cameron J. Nowell, Leonie Cann, Liam R. J. Day, Peter Rogers, Jacqueline F. Donoghue, Helen B. Forrester, Jeffrey C. Crosbie, Jessica Ventura
Publikováno v:
International Journal of Radiation Biology. 97:642-656
γH2AX biodosimetry has been proposed as an alternative dosimetry method for microbeam radiation therapy (MRT) because conventional dosimeters, such as ionization chambers, lack the spatial resolution required to accurately measure the MRT valley dos
Autor:
Carl Norman Sprung, Pavel Lobachevsky, Andrew W. Stevenson, Chris Hall, Helen B. Forrester, Olga A. Martin
Publikováno v:
Radiation Research. 194
Abscopal effects are an important aspect of targeted radiation therapy due to their implication in normal tissue toxicity from chronic inflammatory responses and mutagenesis. Gene expression can be used to determine abscopal effects at the molecular
Autor:
Georgia I. Terzoudi, Andrew W. Stevenson, Chris Hall, Lina Giannakandropoulou, Pavel Lobachevsky, Helen B. Forrester, Jessica Ventura, Carl N. Sprung, Gerasimos Ch Pollakis, Nicole M. Haynes, Alexandros G. Georgakilas, Ioannis S. Pateras, John A. Hamilton, Jason S. Palazzolo, Vassilis G. Gorgoulis, Joel Mason, Olga A. Martin
Publikováno v:
International journal of radiation oncology, biology, physics. 103(5)
Purpose Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new paradigm in radiobiology. We recently reported radiation-induced abscopal effects (RIAEs) in normal tissues; namely, DNA
Publikováno v:
International Journal of Radiation Biology. 75:543-551
To determine the sequences that flank sites of interchromosomal DNA rearrangements and to determine the relative frequency of inter- and intrachromosomal rearrangements induced by 30 Gy gamma-irradiation in a region 5' from exon I of the c-myc gene i