Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Helen Ashwin"'
Autor:
Luke Milross, Bethany Hunter, David McDonald, George Merces, Amanda Thomson, Catharien M.U. Hilkens, John Wills, Paul Rees, Kasim Jiwa, Nigel Cooper, Joaquim Majo, Helen Ashwin, Christopher J.A. Duncan, Paul M. Kaye, Omer Ali Bayraktar, Andrew Filby, Andrew J. Fisher
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104945- (2024)
Summary: Background: Lung damage in severe COVID-19 is highly heterogeneous however studies with dedicated spatial distinction of discrete temporal phases of diffuse alveolar damage (DAD) and alternate lung injury patterns are lacking. Existing studi
Externí odkaz:
https://doaj.org/article/1b7f1a779bc24e5da70f8643842a6531
Autor:
Vivak Parkash, Helen Ashwin, Georgina Jones, Jovana Sadlova, Barbora Vojtkova, Charles Jaffe, Petr Volf, Alison Layton, Paul Kaye, Charles Lacey
Publikováno v:
Clinical Infection in Practice, Vol 15, Iss , Pp 100198- (2022)
Externí odkaz:
https://doaj.org/article/d85b072362ed4ba5897f884c043498e8
Autor:
Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Tomas Becvar, Patrick Lypaczewski, Eli Schwartz, Elizabeth Greensted, Katrien Van Bocxlaer, Marion Pasin, Kai S. Lipinski, Vivak Parkash, Greg Matlashewski, Alison M. Layton, Charles J. Lacey, Charles L. Jaffe, Petr Volf, Paul M. Kaye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Controlled human infection models (CHIMs) provide a pathway for accelerating vaccine development. Here, the authors describe the isolation, characterization, and GMP manufacture of a clinical Leishmania major strain to be used as a resource for CHIM
Externí odkaz:
https://doaj.org/article/ddd377d986694040985714870d5c4e1c
Autor:
Johannes S. P. Doehl, Helen Ashwin, Najmeeyah Brown, Audrey Romano, Samuel Carmichael, Jon W. Pitchford, Paul M. Kaye
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Increasing evidence suggests that in hosts infected with parasites of the Leishmania donovani complex, transmission of infection to the sand fly vector is linked to parasite repositories in the host skin. However, a detailed understanding of the disp
Externí odkaz:
https://doaj.org/article/ca71750692914a0eba30319da4de6ac7
Autor:
Audrey Romano, Najmeeyah Brown, Helen Ashwin, Johannes S. P. Doehl, Jonathan Hamp, Mohamed Osman, Nidhi Dey, Gulab Fatima Rani, Tiago Rodrigues Ferreira, Paul M. Kaye
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Ly6Chi inflammatory monocytes develop in the bone marrow and migrate to the site of infection during inflammation. Upon recruitment, Ly6Chi monocytes can differentiate into dendritic cells or macrophages. According to the tissue environment they can
Externí odkaz:
https://doaj.org/article/7cd5cbb708ee478fb20c92a32723f93d
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Polyparasitism is commonplace in countries where endemicity for multiple parasites exists, and studies in animal models of coinfection have made significant inroads into understanding the impact of often competing demands on the immune sy
Externí odkaz:
https://doaj.org/article/d38458751b9e4eaba44bc51751e561da
Autor:
Vivak Parkash, Helen Ashwin, Jovana Sadlova, Barbora Vojtkova, Georgina Jones, Nina Martin, Elizabeth Greensted, Victoria Allgar, Shaden Kamhawi, Jesus G. Valenzuela, Alison M. Layton, Charles L. Jaffe, Petr Volf, Paul M. Kaye, Charles J. N. Lacey
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Leishmaniasis is a globally important yet neglected parasitic disease transmitted by phlebotomine sand flies. With new candidate vaccines in or near the clinic, a controlled human challenge model (CHIM) using natural sand fly challenge wo
Externí odkaz:
https://doaj.org/article/1b23906551454baab8079e5e896cd479
Autor:
Sarah Forrester, Karin Siefert, Helen Ashwin, Najmeeyah Brown, Andrea Zelmar, Sally James, Dimitris Lagos, Jon Timmis, Mitali Chatterjee, Jeremy C. Mottram, Simon L. Croft, Paul M. Kaye
Publikováno v:
Wellcome Open Research, Vol 4 (2019)
Background: Liposomal amphotericin B (AmBisome®) as a treatment modality for visceral leishmaniasis (VL) has had significant impact on patient care in some but not all regions where VL is endemic. As the mode of action of AmBisome® in vivo is poorl
Externí odkaz:
https://doaj.org/article/b00a9e2df10b4d298ecae3b7426eb87b
Autor:
Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy C Mottram, Simon L. Croft, Paul M. Kaye
Publikováno v:
Wellcome Open Research, Vol 3 (2019)
Background: Human visceral leishmaniasis, caused by infection with Leishmania donovani or L. infantum, is a potentially fatal disease affecting 50,000-90,000 people yearly in 75 disease endemic countries, with more than 20,000 deaths reported. Experi
Externí odkaz:
https://doaj.org/article/ae6de5004bb2437594dff34ff89d995e
Autor:
Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy Mottram, Simon L. Croft, Paul M. Kaye
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Human visceral leishmaniasis, caused by infection with Leishmania donovani or L. infantum, is a potentially fatal disease affecting 50,000-90,000 people yearly in 75 disease endemic countries, with more than 20,000 deaths reported. Experi
Externí odkaz:
https://doaj.org/article/8266bf4fdd7b40bb9ced167a047ba2bd