Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Helen A, Fletcher"'
Development and application of the direct mycobacterial growth inhibition assay: a systematic review
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionFirst described by Wallis et al. in 2001 for the assessment of TB drugs, the direct mycobacterial growth inhibition assay (MGIA) offers a tractable ex vivo tool measuring the combined influences of host immunity, strain virulence and inte
Externí odkaz:
https://doaj.org/article/67204c3110ba49d6b63d248dcd9bae4c
Autor:
Iman Satti, Rachel E. Wittenberg, Shuailin Li, Stephanie A. Harris, Rachel Tanner, Deniz Cizmeci, Ashley Jacobs, Nicola Williams, Humphrey Mulenga, Helen A. Fletcher, Thomas J. Scriba, Michele Tameris, Mark Hatherill, Helen McShane
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The identification of immune correlates of protection in humans would inform on the design and development of tuberculosis vaccine candidates. In this work, authors examine samples collected from South African infants, to determine whether the correl
Externí odkaz:
https://doaj.org/article/fe708fb5f5134f818664bd801fc66d30
Autor:
Rachel Tanner, Andrew D. White, Charelle Boot, Claudia C. Sombroek, Matthew K. O’Shea, Daniel Wright, Emily Hoogkamer, Julia Bitencourt, Stephanie A. Harris, Charlotte Sarfas, Rachel Wittenberg, Iman Satti, Helen A. Fletcher, Frank A. W. Verreck, Sally A. Sharpe, Helen McShane
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract We present a non-human primate mycobacterial growth inhibition assay (MGIA) using in vitro blood or cell co-culture with the aim of refining and expediting early tuberculosis vaccine testing. We have taken steps to optimise the assay using c
Externí odkaz:
https://doaj.org/article/68af0e0e83b24984a10595f180e34dba
Autor:
Patpong Rongkard, Barbara Kronsteiner, Viriya Hantrakun, Kemajittra Jenjaroen, Manutsanun Sumonwiriya, Panjaporn Chaichana, Suchintana Chumseng, Narisara Chantratita, Vanaporn Wuthiekanun, Helen A. Fletcher, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P.J. Day, Susanna J. Dunachie
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 3, Pp 463-471 (2020)
Melioidosis is a neglected tropical disease with an estimated annual mortality rate of 89,000 in 45 countries across tropical regions. The causative agent is Burkholderia pseudomallei, a gram-negative soil-dwelling bacterium. In Thailand, B. pseudoma
Externí odkaz:
https://doaj.org/article/725c33e1264445a6bd66dacfc6e68b3a
Autor:
Hannah Painter, Satria A. Prabowo, Felipe Cia, Lisa Stockdale, Rachel Tanner, Samuel Willcocks, Rajko Reljic, Helen A. Fletcher, Andrea Zelmer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Abstract In the absence of a correlate(s) of protection against human tuberculosis and a validated animal model of the disease, tools to facilitate vaccine development must be identified. We present an optimised ex vivo mycobacterial growth inhibitio
Externí odkaz:
https://doaj.org/article/8e428b49b409439e8ebb3565742e632f
Autor:
Charlotte Sarfas, Andrew D. White, Laura Sibley, Alexandra L. Morrison, Jennie Gullick, Steve Lawrence, Mike J. Dennis, Philip D. Marsh, Helen A. Fletcher, Sally A. Sharpe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In many countries where tuberculosis (TB) is endemic, the Bacillus Calmette–Guérin (BCG) vaccine is given as close to birth as possible to protect infants and children from severe forms of TB. However, BCG has variable efficacy and is not as effec
Externí odkaz:
https://doaj.org/article/23a524431d8548a983dc1bcc98994a67
Autor:
Rachel Tanner, Emily Hoogkamer, Julia Bitencourt, Andrew White, Charelle Boot, Claudia C. Sombroek, Stephanie A. Harris, Matthew K. O'Shea, Daniel Wright, Rachel Wittenberg, Charlotte Sarfas, Iman Satti, Frank A.W. Verreck, Sally A. Sharpe, Helen A. Fletcher, Helen McShane
Publikováno v:
F1000Research, Vol 10 (2021)
The only currently available approach to early efficacy testing of tuberculosis (TB) vaccine candidates is in vivo preclinical challenge models. These typically include mice, guinea pigs and non-human primates (NHPs), which must be exposed to virulen
Externí odkaz:
https://doaj.org/article/f4d160f312314877839761de896f12a2
Autor:
Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate N
Externí odkaz:
https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8
Autor:
Rachel Tanner, Emily Hoogkamer, Julia Bitencourt, Andrew White, Charelle Boot, Claudia C. Sombroek, Stephanie A. Harris, Matthew K. O'Shea, Daniel Wright, Rachel Wittenberg, Charlotte Sarfas, Iman Satti, Frank A.W. Verreck, Sally A. Sharpe, Helen A. Fletcher, Helen McShane
Publikováno v:
F1000Research, Vol 10 (2021)
The only currently available approach to early efficacy testing of tuberculosis (TB) vaccine candidates is in vivo preclinical challenge models. These typically include mice, guinea pigs and non-human primates (NHPs), which must be exposed to virulen
Externí odkaz:
https://doaj.org/article/8d457b8383a642419000e0f51934d0e4
Autor:
Sancho Rodríguez-Villar, Paloma Poza-Hernández, Sascha Freigang, Idoia Zubizarreta-Ormazabal, Daniel Paz-Martín, Etienne Holl, Osvaldo Ceferino Pérez-Pardo, María Sherezade Tovar-Doncel, Sonja Maria Wissa, Bonifacio Cimadevilla-Calvo, Guillermo Tejón-Pérez, Ismael Moreno-Fernández, Alejandro Escario-Méndez, Juan Arévalo-Serrano, Antonio Valentín, Bruno Manuel Do-Vale, Helen Marie Fletcher, Jesús Medardo Lorenzo-Fernández
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248264 (2021)
BackgroundPoint-of-care arterial blood gas (ABG) is a blood measurement test and a useful diagnostic tool that assists with treatment and therefore improves clinical outcomes. However, numerically reported test results make rapid interpretation diffi
Externí odkaz:
https://doaj.org/article/e79a24d0b125445d88f9468445b3a0f9