Výsledky vyhledávání - "Helen J. Newbery"

Akademický článek

Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function.

Autor: Lowri A Griffiths, Jennifer Doig, Antonia M D Churchhouse, Faith C J Davies, Charlotte E Squires, Helen J Newbery, Catherine M Abbott

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e41917 (2012)

Translation elongation factor isoform eEF1A2 is expressed in muscle and neurons. Deletion of eEF1A2 in mice gives rise to the neurodegenerative phenotype "wasted" (wst). Mice homozygous for the wasted mutation die of muscle wasting and neurodegenerat

Externí odkaz: https://doaj.org/article/ece3cf6673794b6fbab4c8e83e32bd3d

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Akademický článek

Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas.

Autor: Zhaoyang Li, Chen-Feng Qi, Dong-Mi Shin, Adriana Zingone, Helen J Newbery, Alexander L Kovalchuk, Catherine M Abbott, Herbert C Morse

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10755 (2010)

The canonical function of EEF1A2, normally expressed only in muscle, brain, and heart, is in translational elongation, but recent studies suggest a non-canonical function as a proto-oncogene that is overexpressed in a variety of solid tumors includin

Externí odkaz: https://doaj.org/article/53a699b93a0e4705813f73c0b1cabec8

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Akademický článek

Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.

Autor: Dinesh C Soares, Paul N Barlow, Helen J Newbery, David J Porteous, Catherine M Abbott

Publikováno v: PLoS ONE, Vol 4, Iss 7, p e6315 (2009)

BACKGROUND:Despite sharing 92% sequence identity, paralogous human translation elongation factor 1 alpha-1 (eEF1A1) and elongation factor 1 alpha-2 (eEF1A2) have different but overlapping functional profiles. This may reflect the differential require

Externí odkaz: https://doaj.org/article/acdb1a2291264173a3c3b61522594b06

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In vivo translatome profiling reveals early defects in ribosome biology underlying SMA pathogenesis

Autor: Francesca Mattedi, Paola Bernabo, Thomas H. Gillingwater, Toma Tebaldi, Helen J. Newbery, Gabriella Viero, Elena Perenthaler, Fiona M. Lane, Paola Zuccotti, Ewout J N Groen, Francesco Muntoni, Haiyan Zhou, Alessandro Quattrone, Potrich

BackgroundGenetic alterations impacting on ubiquitously expressed proteins involved in mRNA metabolism often result in neurodegenerative conditions, with increasing evidence suggesting that translational defects can contribute to disease. Spinal Musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9bdbe3df2cc3e644e65cff5bc17e8f3
https://doi.org/10.1101/103481

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Translation Elongation Factor eEF1A2 Is Essential for Post-weaning Survival in Mice

Autor: V A L Tomlinson, Helen J Newbery, You-Ying Chau, Jan H. Bergmann, David Brownstein, Julia Boyd, Dawn H. Loh, Jean E O’Donoghue, Catherine M. Abbott

Publikováno v: Journal of Biological Chemistry. 282:28951-28959

Translation elongation factor eEF1A, formerly known as EF-1 alpha, exists as two variant forms; eEF1A1, which is almost ubiquitously expressed, and eEF1A2, whose expression is restricted to muscle and brain at the level of whole tissues. Expression a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b8a875457dcd3600ed573839f2459f
https://doi.org/10.1074/jbc.m703962200

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Progressive Loss of Motor Neuron Function in Wasted Mice: Effects of a Spontaneous Null Mutation in the Gene for the eEF1A2 Translation Factor

Autor: Josephine Peters, Derek Thomson, Permphan Dharmasaroja, Catherine M. Abbott, Thomas H. Gillingwater, Stephen B. Wharton, Helen J Newbery, Richard R. Ribchester

Publikováno v: Journal of Neuropathology & Experimental Neurology. 64:295-303

Wasted (wst) is a spontaneous autosomal recessive mutation in which the gene encoding translation factor eEF1A2 is deleted. Homozygous mice show tremors and disturbances of gait shortly after weaning, followed by motor neuron degeneration, paralysis,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712415aa0fe3844b105e21c610aaabe9
https://doi.org/10.1093/jnen/64.4.295

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In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy

Autor: Permphan Dharmasaroja, Maria Vera, Lowri A Griffiths, David G. Brownstein, Helen J Newbery, Faith J. C. Davies, David Peberdy, Jennifer Doig, Catherine M. Abbott

Publikováno v: Doig, J, Griffiths, L A, Peberdy, D, Dharmasaroja, P, Vera, M, Davies, F J C, Newbery, H J, Brownstein, D & Abbott, C M 2013, ' In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy ', Febs Journal, vol. 280, no. 24, pp. 6528-6540 . https://doi.org/10.1111/febs.12554
The Febs Journal

Translation elongation factor1A2 (eEF1A2), uniquely among translation factors, is expressed specifically in neurons and muscle. eEF1A2-null mutant wasted mice develop an aggressive, early-onset form of neurodegeneration, but it is unknown whether the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68afeccaca769d7cab9ed88f26855be
https://hdl.handle.net/20.500.11820/71501528-23c8-4e3c-8c13-fac234760808

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eEF1A2 and neuronal degeneration

Autor: Catherine M. Abbott, Charlotte E. Squires, Helen J Newbery, David G. Brownstein, Dinesh C. Soares, Lowri A Griffiths

Publikováno v: Abbott, C M, Newbery, H J, Squires, C E, Brownstein, D, Griffiths, L A & Soares, D C 2009, ' eEF1A2 and neuronal degeneration ', Biochemical Society Transactions, vol. 37, no. Pt 6, pp. 1293-7 . https://doi.org/10.1042/BST0371293

Translation elongation factor eEF1A (eukaryotic elongation factor 1A) exists as two individually encoded variants in mammals, which are 98% similar and 92% identical at the amino acid level. One variant, eEF1A1, is almost ubiquitously expressed, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295fa6f3dcea4830dc5b6bd12f4d486c
https://www.pure.ed.ac.uk/ws/files/9476835/eEF1A2_and_neuronal_degeneration.pdf

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Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas

Autor: Helen J Newbery, Chen-Feng Qi, Dong-Mi Shin, Herbert C. Morse, Catherine M. Abbott, Zhaoyang Li, Adriana Zingone, Alexander L. Kovalchuk

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 5, p e10755 (2010)
Li, Z, Qi, C-F, Shin, D-M, Zingone, A, Newbery, H J, Kovalchuk, A L, Abbott, C M & Morse, H C 2010, ' Eef1a2 Promotes Cell Growth, Inhibits Apoptosis and Activates JAK/STAT and AKT Signaling in Mouse Plasmacytomas ', PLoS ONE, vol. 5, no. 5, e10755, pp.-. https://doi.org/10.1371/journal.pone.0010755

Background: The canonical function of EEF1A2, normally expressed only in muscle, brain, and heart, is in translational elongation, but recent studies suggest a non-canonical function as a proto-oncogene that is overexpressed in a variety of solid tum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f240016588216068215e593702b5e35c
https://pubmed.ncbi.nlm.nih.gov/20505761

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