Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer

Autor: Jennifer H. Barrett, Lars Dyrskjøt, Margaret A. Knowles, Torben F. Ørntoft, Jørgen Bjerggaard Jensen, Helen Snowden, Mark Teo, Michael Borre, Graham R. Taylor, Anne E. Kiltie, Joanne E. Morgan, Jérémie Nsengimana, D T Bishop, Christian von Buchwald

Publikováno v: Teo, M T W, Dyrskjøt, L, Nsengimana, J, Buchwald, C, Snowden, H, Morgan, J, Jensen, J B, Knowles, M A, Taylor, G, Barrett, J H, Borre, M, Orntoft, T F, Bishop, D T & Kiltie, A E 2014, ' Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer ', Annals of Oncology, vol. 25, no. 4, pp. 877-83 . https://doi.org/10.1093/annonc/mdu014
Annals of Oncology; Vol 25
Annals of Oncology

Genetic variants could be useful as predictors of radiotherapy outcomes. Here we studied germline MRE11A variants in muscle invasive bladder cancer patients and found six rare variants and one SNP, rs1805363, to be associated with worse radiotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a6b41f7d484569ea3cee91655b185f
https://ora.ox.ac.uk/objects/uuid:1b22cd1a-419d-4e77-a5cd-99113f73a8f9

MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma

Autor: Pascal Wolter, Marianne Frostvik Stolt, Rosalyn Jewell, Johan Hansson, Carolina Johansson, Christer Lindholm, Joost van den Oord, Ulrika Stierner, Diana Linden, Christy Walker, Suzanne Egyhazi Brage, Rainer Tuominen, Helen Snowden, Julia Newton-Bishop, Hemming Johansson

Publikováno v: International Journal of Cancer. 136:2844-2853

To investigate the predictive and prognostic value of O(6) -methylguanine DNA methyltransferase (MGMT) inactivation by analyses of promoter methylation in pretreatment tumor biopsies from patients with cutaneous melanoma treated with dacarbazine (DTI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee8ac4e5314a9d14ddb3bb182bdda303
https://doi.org/10.1002/ijc.29332

Genome-wide association study identifies three new melanoma susceptibility loci

Autor: Eitan Friedman, Shenying Fang, Jeffrey E. Lee, Esther Azizi, Marie-Françoise Avril, Douglas F. Easton, Julia A. Newton Bishop, Julie Lang, Elizabeth M. Gillanders, Juliette Randerson-Moor, Jan Lubinski, D. Timothy Bishop, Bruce K. Armstrong, Donato Calista, Florence Demenais, Joan Anton Puig-Butille, Anne E. Cust, Tadeusz Dȩbniak, Graham G. Giles, Grant W. Montgomery, Lorenza Pastorino, David C. Whiteman, Kevin M. Brown, Nicholas G. Martin, Diana Zelenika, Maria Teresa Landi, Jennifer H. Barrett, Veronica Höiom, Pilar Galan, Qingyi Wei, Johan Hansson, Lars A. Akslen, Bert Bakker, Brigitte Bressac-de Paillerets, Josep Malvehy, Rainer Tuominen, Wilma Bergman, Mark M. Iles, Stuart MacGregor, Jiali Han, Rona M. MacKie, Nicholas K. Hayward, Richard F. Kefford, Mark A. Jenkins, Christian Ingvar, Anders Molven, Graham J. Mann, Lisa A. Cannon-Albright, David E. Elder, Göran Jönsson, Joanne F. Aitken, Mark Harland, John L. Hopper, David L. Duffy, Eve Corda, Helen Snowden, Peter A. Kanetsky, Alisa M. Goldstein, Alison M. Dunning, John C. Taylor, Giorgio Landi, Håkan Olsson, Paola Ghiorzo, Nienke van der Stoep, Bart Janssen, Per Arne Andresen, Susana Puig, Nelleke A. Gruis, Marko Hočevar, Frans A. van Nieuwpoort, Srdjan Novaković, G. Mark Lathrop, Patricia Van Belle, Giovanna Bianchi-Scarrà, Christopher I. Amos

Publikováno v: Nature genetics
Nature Genetics, 43(11), 1108-U98
Nature Genetics
Nature Genetics, Nature Publishing Group, 2011, 43 (11), pp.1108-U98. ⟨10.1038/ng.959⟩
Dipòsit Digital de la UB
Universidad de Barcelona

We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709d559a17530681126b93462d532230
http://europepmc.org/articles/PMC3251256

Developing a local shared care protocol for managing people with psychotic illness in primary care

Autor: Helen Snowden, Sarah Marriott

Publikováno v: Psychiatric Bulletin. 27:261-266

Aims and Method The National Service Framework sets standards to improve the treatment of mental health on a national level, and requires the development of localised shared care protocols. We aimed to develop a shared care protocol for use in local

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81fb876bce8422173c7fa94e018dea2
https://doi.org/10.1017/s0955603600002555

MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma

Autor: Rainer, Tuominen, Rosalyn, Jewell, Joost J, van den Oord, Pascal, Wolter, Ulrika, Stierner, Christer, Lindholm, Carolina, Hertzman Johansson, Diana, Lindén, Hemming, Johansson, Marianne, Frostvik Stolt, Christy, Walker, Helen, Snowden, Julia, Newton-Bishop, Johan, Hansson, Suzanne, Egyházi Brage

Publikováno v: International journal of cancer. 136(12)

To investigate the predictive and prognostic value of O(6) -methylguanine DNA methyltransferase (MGMT) inactivation by analyses of promoter methylation in pretreatment tumor biopsies from patients with cutaneous melanoma treated with dacarbazine (DTI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a4c0284700fa6eb731bc9256d93a88ea
https://pubmed.ncbi.nlm.nih.gov/25400033