Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Helen, Kiriazis"'
Autor:
Nicola M. Sergienko, Adam J. Trewin, Helen Kiriazis, Antonia J. A. Raaijmakers, Daniel G. Donner, Victoria C. Garside, Kelly A. Smith, James R. Bell, Kimberley M. Mellor, Lea M. D. Delbridge, Julie R. McMullen, Kate L. Weeks
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-13 (2024)
Abstract Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing HDAC5/MEF2 signalling in cardiomyocytes. We created and characterised two mouse models
Externí odkaz:
https://doaj.org/article/962f0a0f34444cd0b5607aa60b031817
Autor:
Bing H. Wang, Remy Robert, Francine Z. Marques, Niwanthi Rajapakse, Helen Kiriazis, Charles R. Mackay, David M. Kaye
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis. Here we tested the hypothesis that CXCR7, a highly conserved chemokine receptor, contr
Externí odkaz:
https://doaj.org/article/39ae76b2ee2b4c3481cce768b048591b
Publikováno v:
Physiological Reports, Vol 12, Iss 20, Pp n/a-n/a (2024)
Abstract Correlation between echocardiographic and pathoanatomic variables and their prognostic value in murine cardiomyopathy models remain unknown. Using echocardiography, morphometrics, and survival monitoring, we characterized transgenic (TG) mic
Externí odkaz:
https://doaj.org/article/e42dbb47373948f4a946a06a8eb4d624
Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes
Autor:
Aowen Zhuang, Yanie Tan, Yingying Liu, Christine Yang, Helen Kiriazis, Kyah Grigolon, Shannen Walker, Simon T. Bond, Julie R. McMullen, Anna C. Calkin, Brian G. Drew
Publikováno v:
Physiological Reports, Vol 11, Iss 23, Pp n/a-n/a (2023)
Abstract Long ncRNAs (lncRNAs) have been shown to play a biological and physiological role in various tissues including the heart. We and others have previously established that the lncRNA Oip5os1 (1700020I14Rik, OIP5‐AS1, Cyrano) is enriched in st
Externí odkaz:
https://doaj.org/article/1b95d6a3a9ba480f80f77c3578a83ad1
Autor:
Charles D. Cohen, Miles J. De Blasio, Gabriella E. Farrugia, Malathi S.I. Dona, Ian Hsu, Darnel Prakoso, Helen Kiriazis, Crisdion Krstevski, David M. Nash, Mandy Li, Taylah L. Gaynor, Minh Deo, Grant R. Drummond, Rebecca H. Ritchie, Alexander R. Pinto
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107759- (2023)
Summary: Diabetes is associated with a significantly elevated risk of heart failure. However, despite extensive efforts to characterize the phenotype of the diabetic heart, the molecular and cellular protagonists that underpin cardiac pathological re
Externí odkaz:
https://doaj.org/article/d504173b55ce4ebe84dc49ae7fdf7e65
Autor:
Charles D. Cohen, Miles J. De Blasio, Man K. S. Lee, Gabriella E. Farrugia, Darnel Prakoso, Crisdion Krstevski, Minh Deo, Daniel G. Donner, Helen Kiriazis, Michelle C. Flynn, Taylah L. Gaynor, Andrew J. Murphy, Grant R. Drummond, Alexander R. Pinto, Rebecca H. Ritchie
Publikováno v:
Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-12 (2021)
Abstract Background Diabetes is associated with a significantly elevated risk of cardiovascular disease and its specific pathophysiology remains unclear. Recent studies have changed our understanding of cardiac cellularity, with cellular changes acco
Externí odkaz:
https://doaj.org/article/88aaad0eb056450fa3ffbe56d0335c20
Autor:
Simon T. Bond, Aowen Zhuang, Christine Yang, Eleanor A.M. Gould, Tim Sikora, Yingying Liu, Ying Fu, Kevin I. Watt, Yanie Tan, Helen Kiriazis, Graeme I. Lancaster, Paul Gregorevic, Darren C. Henstridge, Julie R. McMullen, Peter J. Meikle, Anna C. Calkin, Brian G. Drew
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101292- (2021)
Objective: CRISPR/Cas9 technology has revolutionized gene editing and fast tracked our capacity to manipulate genes of interest for the benefit of both research and therapeutic applications. Whilst many advances have, and continue to be made in this
Externí odkaz:
https://doaj.org/article/9b56d5f453674ef7a4d560824691508a
Autor:
Mitchel Tate, Nimna Perera, Darnel Prakoso, Andrew M. Willis, Minh Deo, Osezua Oseghale, Hongwei Qian, Daniel G Donner, Helen Kiriazis, Miles J. De Blasio, Paul Gregorevic, Rebecca H. Ritchie
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Diabetes is a major contributor to the increasing burden of heart failure prevalence globally, at least in part due to a disease process termed diabetic cardiomyopathy. Diabetic cardiomyopathy is characterised by cardiac structural changes that are c
Externí odkaz:
https://doaj.org/article/2b6aa04b548c47ee98472cd4def7dc08
Autor:
Alex M. Parker, Mitchel Tate, Darnel Prakoso, Minh Deo, Andrew M. Willis, David M. Nash, Daniel G. Donner, Simon Crawford, Helen Kiriazis, Cesare Granata, Melinda T. Coughlan, Miles J. De Blasio, Rebecca H. Ritchie
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
People affected by diabetes are at an increased risk of developing heart failure than their non-diabetic counterparts, attributed in part to a distinct cardiac pathology termed diabetic cardiomyopathy. Mitochondrial dysfunction and excess reactive ox
Externí odkaz:
https://doaj.org/article/41a69cb22fe945b8a7151b8c5c3a1286
Autor:
Bianca C. Bernardo, Gunes S. Yildiz, Helen Kiriazis, Claudia A. Harmawan, Celeste M. K. Tai, Rebecca H. Ritchie, Julie R. McMullen
Publikováno v:
Cells, Vol 11, Iss 19, p 3117 (2022)
MicroRNA 34a (miR-34a) is elevated in the heart in a setting of cardiac stress or pathology, and we previously reported that inhibition of miR-34a in vivo provided protection in a setting of pressure overload-induced pathological cardiac hypertrophy
Externí odkaz:
https://doaj.org/article/cbe1a51af347431b9d1db920218b859c