Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Helen, Heffron"'
Autor:
Jennifer Turney, Henriëtte M. G. Willems, Philip J. Mitchell, Vivienne Allen, Alan G. Hendrick, Takashi Ito, Jenny Reeves, Susanne Wright, Ilka Müller, Richard J. Davenport, Richard Bazin, Stephen Wilkinson, Philip Leonard, Helen Heffron, Steve Irving
Publikováno v:
Journal of Medicinal Chemistry. 59:8094-8102
Fatty acid binding protein 6 (FABP6) is a potential drug discovery target, which, if inhibited, may have a therapeutic benefit for the treatment of diabetes. Currently, there are no published inhibitors of FABP6, and with the target believed to be am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb461ea8115897027e5a13fb8162307c
https://doi.org/10.1021/acs.jmedchem.6b00869
https://doi.org/10.1021/acs.jmedchem.6b00869
Autor:
K. Real, Matt Barnes, Richard J. Davenport, Helen M. Cox, Robert Newman, Stuart Stafford, Helen Heffron, Johannes Grosse, Sarah Forbes, Gareth Coope
Publikováno v:
Diabetes. 64:3763-3771
Free fatty acid receptor 2 (FFA2) is expressed on enteroendocrine L cells that release glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) when activated by short-chain fatty acids (SCFAs). Functionally GLP-1 and PYY inhibit gut transit, increase gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9691959fca26e3bb88814cbebc62e29c
https://doi.org/10.2337/db15-0481
https://doi.org/10.2337/db15-0481
Autor:
Fiona M. Gribble, Abdella M. Habib, Frank Reimann, Eleftheria Diakogiannaki, Helen E. Parker, Gwen Tolhurst, Helen Heffron, Yu Shan Lam, Johannes Grosse, Jennifer Cameron
Publikováno v:
Diabetes
Interest in how the gut microbiome can influence the metabolic state of the host has recently heightened. One postulated link is bacterial fermentation of “indigestible” prebiotics to short-chain fatty acids (SCFAs), which in turn modulate the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a06844111e2f2768d3fb67e419eeba
https://doi.org/10.2337/db11-1019
https://doi.org/10.2337/db11-1019
Autor:
Michael Patterson, Kate Hardy, Stephen Franks, Ilpo Huhtaniemi, Helen Heffron, Ivan Diakonov, Colin Selman, Dominic J. Withers, Agharul I. Choudhury, Stephen R. Bloom, Hind Al-Qassab, Irina Neganova, Mohammad A. Ghatei, Steven J. Lingard
Publikováno v:
Biology of Reproduction. 76:1045-1053
Insulin receptor signaling regulates female reproductive function acting in the central nervous system and ovary. Female mice that globally lack insulin receptor substrate (IRS) 2, which is a key mediator of insulin receptor action, are infertile wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e48a595b1411dde198132465555564b
https://doi.org/10.1095/biolreprod.106.059360
https://doi.org/10.1095/biolreprod.106.059360
Autor:
Agharul I. Choudhury, Steven J. Lingard, Shanta J. Persaud, Helen Heffron, Pedro Luis Herrera, Henry Asare-Anane, James Cantley, Dominic J. Withers, Colin Selman
Publikováno v:
Diabetologia, Vol. 50, No 6 (2007) pp. 1248-1256
AIMS/HYPOTHESIS: Insulin signalling pathways regulate pancreatic beta cell function. Conditional gene targeting using the Cre/loxP system has demonstrated that mice lacking insulin receptor substrate 2 (IRS2) in the beta cell have reduced beta cell m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecfd9064eec1a13a8284f7d2bee4f85
https://doi.org/10.1007/s00125-007-0637-9
https://doi.org/10.1007/s00125-007-0637-9
Autor:
Dominic J. Withers, Hind Al-Qassab, Mark A. Smith, Michael L.J. Ashford, Kazunari Hisadome, Helen Heffron
Publikováno v:
The Journal of Physiology. 578:425-438
The hypothalamic melanocortin system is crucial for the control of appetite and body weight. Two of the five melanocortin receptors, MC3R and MC4R are involved in hypothalamic control of energy homeostasis, with the MC4R having the major influence. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49171275bec180cc58d7a38f6c0ba281
https://doi.org/10.1113/jphysiol.2006.119479
https://doi.org/10.1113/jphysiol.2006.119479
Autor:
David C. Bedford, James Cantley, Agharul I. Choudhury, Miguel A. Iglesias, Helen Heffron, Rémy Burcelin, Marika Charalambous, Antonio Vidal-Puig, Miguel López, M. Simmgen, Dominic J. Withers, Marc Claret, Claude Knauf, Patrice D. Cani
Publikováno v:
Diabetologia. 49:552-561
AIMS/HYPOTHESIS: Hepatic insulin resistance is thought to be a critical component in the pathogenesis of type 2 diabetes but the role of intrinsic insulin signalling pathways in the regulation of hepatic metabolism remains controversial. Global gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e194bc96a3bcfd0c7b78945ce9daa355
https://doi.org/10.1007/s00125-005-0084-4
https://doi.org/10.1007/s00125-005-0084-4
Autor:
Mark A. Smith, Helen Heffron, Allison W. Xu, John R. Speakman, Michael L.J. Ashford, Gavin MacColl, Agharul I. Choudhury, Vazira Moosajee, Jimmy D. Bell, Marcus Simmgen, David C. Bedford, Gregory S. Barsh, Rachel L. Batterham, Ivan Diakonov, Marc Claret, Hind Al-Qassab, Kazunari Hisadome, Melanie Clements, Colin Selman, Dominic J. Withers
Publikováno v:
Journal of Clinical Investigation. 115:940-950
Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons (PO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be2afee2881ebbe641b494620fe7a9e
https://doi.org/10.1172/jci24445
https://doi.org/10.1172/jci24445
Autor:
Samuel Aparicio, Yukio Toyoda, William H. Colledge, Rachel Larder, Laura Parton, Justin Powell, Keith Burling, Debra Rimmington, Helen Heffron, Fiona M. Gribble, Stephen O'Rahilly, Anthony P. Coll, Mark B. L. Carlton, Matteo Binda, Abdella M. Habib, John D. Wade, Paul Richards, Johannes Grosse, Joanne Doran, Mohammed Akhter Hossain, Alice A. Adriaenssens, Frank Reimann, Gareth J. Rogers
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(30)
Significance Hormonal factors from specialized enteroendocrine cells in the gut epithelium link the availability of dietary nutrients to energy utilization and storage. Many gut hormones also affect behaviors such as appetite and foraging, conveying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ad4f4c0f4a2fa41aff0b2a9010cb53
https://pubmed.ncbi.nlm.nih.gov/25028498
https://pubmed.ncbi.nlm.nih.gov/25028498
Autor:
Allison W. Xu, Mark A. Smith, Benoit Viollet, Melanie Clements, Colin Selman, Hind Al-Qassab, Lee G.D. Fryer, Sophie Vaulont, Rachel L. Batterham, Dominic J. Withers, Helen Heffron, David Carling, Gregory S. Barsh, Agharul I. Choudhury, John R. Speakman, Marc Claret, Michael L.J. Ashford
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis. However, the precise neuronal populations and cellular mechanisms inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05964a8b58082386bb8c6b8e9853138
https://europepmc.org/articles/PMC1934578/
https://europepmc.org/articles/PMC1934578/
