Health-related quality of life in transplant ineligible newly diagnosed multiple myeloma patients treated with either thalidomide or lenalidomide-based regimen until progression: a prospective, open-label, multicenter, randomized, phase 3 study

Autor: Lene Kongsgaard Nielsen, Claudia Stege, Birgit Lissenberg-Witte, Bronno van der Holt, Ulf-Henrik Mellqvist, Morten Salomo, Gerard Bos, Mark-David Levin, Heleen Visser-Wisselaar, Markus Hansson, Annette van der Velden, Wendy Deenik, Juleon Coenen, Maja Hinge, Saskia Klein, Bea Tanis, Damian Szatkowski, Rolf Brouwer, Matthijs Westerman, Rineke Leys, Harm Sinnige, Einar Haukås, Klaas van der Hem, Marc Durian, Peter Gimsing, Niels van de Donk, Pieter Sonneveld, Anders Waage, Niels Abildgaard, Sonja Zweegman

Publikováno v: Haematologica, Vol 105, Iss 6 (2020)

Data on the impact of long term treatment with immunomodulatory drugs (IMiD) on health-related quality of life (HRQoL) is limited. The HOVON-87/NMSG18 study was a randomized, phase 3 study in newly diagnosed transplant ineligible patients with multip

Externí odkaz: https://doaj.org/article/ed3611ab0ceb40df9134edf248aba092

Dysplasia and PNH-type cells in bone marrow aspirates of myelodysplastic syndromes

Autor: Dana A. Chitu, Canan Alhan, Arjan A. van de Loosdrecht, Heleen Visser-Wisselaar, Theresia M. Westers

Publikováno v: Westers, T M, Alhan, C, Visser-Wisselaar, H A, Chitu, D A & van de Loosdrecht, A A 2021, ' Dysplasia and PNH-type cells in bone marrow aspirates of myelodysplastic syndromes ', Cytometry Part B-Clinical Cytometry . https://doi.org/10.1002/cyto.b.22038
Cytometry Part B-Clinical Cytometry, 104(2), 162-172. Wiley-Liss Inc.
Cytometry Part B-Clinical Cytometry. Wiley-Liss Inc.

Background: Flow cytometry is increasingly applied in cytopenic patients suspected for myelodysplastic syndromes (MDS). Analysis includes evaluation of antigen expression patterns in granulocytes of which, for example, partial lack of CD16 may indica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582eacc791d99baed6e7e15042ede096
https://research.vumc.nl/en/publications/5d6fca22-6184-4431-bd38-0cc645addda3

Machine Learning-Based Flow Cytometry Diagnostics in Myelodysplastic Syndromes: Validation in the HOVON89 Clinical Trial (EudraCT 2008-002195-10)

Autor: Theresia M. Westers, Joop H. Jansen, Canan Alhan, Costa Bachas, Arjan A. van de Loosdrecht, Sofie Van Gassen, Yvan Saeys, Carolien Duetz, Eline M. P. Cremers, Margot F. van Spronsen, Aniek O. de Graaf, Florentien E. M. in ’t Hout, Dana A. Chitu, Heleen Visser-Wisselaar

Publikováno v: Blood, 136. American Society of Hematology
Duetz, C, Van Gassen, S, Westers, T M, in 't Hout, F, Cremers, E, Alhan, C, Bachas, C, Van Spronsen, M F, Visser-Wisselaar, H, Chitu, D, De Graaf, A O, Jansen, J, Saeys, Y & van de Loosdrecht, A 2020, ' Machine Learning-Based Flow Cytometry Diagnostics in Myelodysplastic Syndromes: Validation in the HOVON89 Clinical Trial (EudraCT 2008-002195-10) ', Blood, vol. 136 . https://doi.org/10.1182/blood-2020-136719

Introduction Flow cytometry is a recommended tool in the diagnostic work-up of cytopenic patients suspected for myelodysplastic syndromes. Currently used flow cytometry scores rely on human assessment of dysplastic features in the bone marrow. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b733e1e6d642fa9160cd22ab22cf568
https://research.vumc.nl/en/publications/258b89fd-5538-42b7-941a-639363db9f3b

Health-Related Quality of Life in Transplant Ineligible Newly Diagnosed Multiple Myeloma Patients Treated with Either Thalidomide or Lenalidomide-Based Regimen Until Progression (HOVON-87/NMSG18 Study): A Prospective, Open-Label, Multicenter, Randomized, Phase 3 Study

Autor: Annette W.G. van der Velden, Bronno van der Holt, Gerard M. J. Bos, Harm Sinnige, Anders Waage, Ulf-Henrik Mellqvist, Damian L. Szatkowski, Klaas G. van der Hem, Markus Hansson, Peter Gimsing, Pieter Sonneveld, Juleon Coenen, Morten Salomo, Rineke B. L. Leys, Einar Haukås, Lene Kongsgaard Nielsen, Sonja Zweegman, Mark-David Levin, Saskia K. Klein, Niels Abildgaard, Heleen Visser-Wisselaar, Wendy Deenik, Maja Hinge, Matthijs Westerman, Birgit I. Lissenberg-Witte, Claudia A.M. Stege, Niels W.C.J. van de Donk

Publikováno v: SSRN Electronic Journal.

Background: The overall survival of patients with Multiple Myeloma has improved due to effective, often continuous, therapy. However, knowledge on the impact of long term treatment on health-related quality of life (HRQoL) is limited. Methods: The HO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5420d8549625c8ed48baac5b90b139d
https://doi.org/10.2139/ssrn.3337896

Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes

Autor: Petra Muus, Pedro da Silva-Coelho, Theresia M. Westers, Edo Vellenga, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht, Joop H. Jansen, Canan Alhan, Georgina E. de Greef, Vincent H.J. van der Velden, Jeroen G. te Marvelde, Eline M. P. Cremers, Saskia K. Klein, Marie Cecile J.C. Legdeur, Claudia Cali, Pierre W. Wijermans, Marian Stevens-Kroef, Dana A. Chitu, Heleen Visser-Wisselaar

Publikováno v: Haematologica, 102, 2, pp. 320-326
Haematologica, 102, 320-326
Haematologica, 102(2), 320-326. FERRATA STORTI FOUNDATION
Cremers, E M P, Westers, T M, Alhan, C, Cali, C, Visser-Wisselaar, H A, Chitu, D A, van der Velden, V H J, te Marvelde, J G, Klein, S K, Muus, P, Vellenga, E, de Greef, G E, Legdeur, M C C J C, Wijermans, P W, Stevens-Kroef, M J P L, da Silva-Coelho, P, Jansen, J H, Ossenkoppele, G J, van de Loosdrecht, A A & HOVON89 study group 2017, ' Implementation of erythroid lineage analysis by flow cytometry in diagnostic models for myelodysplastic syndromes ', Haematologica, vol. 102, no. 2, pp. 320-326 . https://doi.org/10.3324/haematol.2016.147843
Haematologica, 102(2), 320-326. Ferrata Storti Foundation

Contains fulltext : 169708.pdf (Publisher’s version ) (Open Access) Flow cytometric analysis is a recommended tool in the diagnosis of myelodysplastic syndromes. Current flow cytometric approaches evaluate the (im)mature myelo-/monocytic lineage wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665c4035e407077a251915bdbf2a9a76
https://hdl.handle.net/2066/169708