Laser-induced vapour nanobubbles improve drug diffusion and efficiency in bacterial biofilms

Autor: Eline Teirlinck, Ranhua Xiong, Toon Brans, Katrien Forier, Juan Fraire, Heleen Van Acker, Nele Matthijs, Riet De Rycke, Stefaan C. De Smedt, Tom Coenye, Kevin Braeckmans

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Eradication of bacterial infections can be hindered by poor penetration of antibiotics through biofilms. Here, Teirlinck et al. show that laser-induced vapour nanobubbles formed around plasmonic nanoparticles can be used to locally disturb biofilm in

Externí odkaz: https://doaj.org/article/38e137de19b54a1fbd1552f4fff64076

Host metabolites stimulate the bacterial proton motive force to enhance the activity of aminoglycoside antibiotics.

Autor: Aurélie Crabbé, Lisa Ostyn, Sorien Staelens, Charlotte Rigauts, Martijn Risseeuw, Maarten Dhaenens, Simon Daled, Heleen Van Acker, Dieter Deforce, Serge Van Calenbergh, Tom Coenye

Publikováno v: PLoS Pathogens, Vol 15, Iss 4, p e1007697 (2019)

Antibiotic susceptibility of bacterial pathogens is typically evaluated using in vitro assays that do not consider the complex host microenvironment. This may help explaining a significant discrepancy between antibiotic efficacy in vitro and in vivo,

Externí odkaz: https://doaj.org/article/2706a68c47b6435aaafd17978aab5542

Elucidation of the mechanism behind the potentiating activity of baicalin against Burkholderia cenocepacia biofilms.

Autor: Lisa Slachmuylders, Heleen Van Acker, Gilles Brackman, Andrea Sass, Filip Van Nieuwerburgh, Tom Coenye

Publikováno v: PLoS ONE, Vol 13, Iss 1, p e0190533 (2018)

Reduced antimicrobial susceptibility due to resistance and tolerance has become a serious threat to human health. An approach to overcome this reduced susceptibility is the use of antibiotic adjuvants, also known as potentiators. These are compounds

Externí odkaz: https://doaj.org/article/b108b88035994e41b1c9bc39a27d655c

Rothia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease

Autor: Juliana Aizawa, Aurélie Crabbé, Lisa Ostyn, Charlotte Rigauts, Michael M. Tunney, Paul Cos, Lucy D. Burr, Jodie L. Simpson, Heleen Van Acker, Cristina Cigana, Lars Vereecke, Anne Willems, Matthias Govaerts, Tom Coenye, Mozes Sze, Eva Vandeplassche, Geraint B. Rogers, Steven L. Taylor, Alessandra Bragonzi, Sarah K. Sims, Yves Dondelinger

Publikováno v: The European respiratory journal
EUROPEAN RESPIRATORY JOURNAL
Rigauts, C, Aizawa, J, Taylor, S, Rogers, G B, Govaerts, M, Cos, P, Ostyn, L, Sims, S, Vandeplassche, E, Sze, M, Dondelinger, Y, Vereecke, L, Van Acker, H, Simpson, J L, Burr, L, Willems, A, Tunney, M M, Cigana, C, Bragonzi, A, Coenye, T & Crabbé, A 2022, ' Rothia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease ', European Respiratory Journal, vol. 59, no. 5 . https://doi.org/10.1183/13993003.01293-2021

BackgroundChronic airway inflammation is the main driver of pathogenesis in respiratory diseases such as severe asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF) and bronchiectasis. While the role of common pathogens in airway infla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8dd902fcac75cecf4e53410d0f9e1f
https://hdl.handle.net/10067/1882970151162165141

Biofilm-grown Burkholderia cepacia complex cells survive antibiotic treatment by avoiding production of reactive oxygen species.

Autor: Heleen Van Acker, Andrea Sass, Silvia Bazzini, Karen De Roy, Claudia Udine, Thomas Messiaen, Giovanna Riccardi, Nico Boon, Hans J Nelis, Eshwar Mahenthiralingam, Tom Coenye

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e58943 (2013)

The presence of persister cells has been proposed as a factor in biofilm resilience. In the present study we investigated whether persister cells are present in Burkholderia cepacia complex (Bcc) biofilms, what the molecular basis of antimicrobial to

Externí odkaz: https://doaj.org/article/75a0f0af5a134ed496e64330d8a78629