Výsledky vyhledávání - "Heleen Roose"

Akademický článek

Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)

Background Modulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg populatio

Externí odkaz: https://doaj.org/article/f3b73327b159432399d5c58c01682dd6

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Akademický článek

The Stem Cell Connection of Pituitary Tumors

Autor: Hugo Vankelecom, Heleen Roose

Publikováno v: Frontiers in Endocrinology, Vol 8 (2017)

Tumors in the pituitary gland are typically benign but cause serious morbidity due to compression of neighboring structures and hormonal disruptions. Overall, therapy efficiency remains suboptimal with negative impact on health and comfort of life, i

Externí odkaz: https://doaj.org/article/788a46b489fd44ba8708244a35b1c68c

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Exploring stem cell biology in pituitary tumors and derived organoids

Autor: Charlotte Nys, Yu-Lun Lee, Heleen Roose, Freya Mertens, Ellen De Pauw, Hiroto Kobayashi, Raf Sciot, Marie Bex, Georges Versyck, Steven De Vleeschouwer, Johannes Van Loon, Emma Laporte, Hugo Vankelecom

Publikováno v: Endocrine-Related Cancer. 29:427-450

Pituitary tumorigenesis is highly prevalent and causes major endocrine disorders. Hardly anything is known on the behavior of the local stem cells in this pathology. Here, we explored the stem cells’ biology in mouse and human pituitary tumors usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68366dc45459062c285e8780ce0b6c98
https://doi.org/10.1530/erc-21-0374

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Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
JOURNAL FOR IMMUNOTHERAPY OF CANCER
Journal for Immunotherapy of Cancer

BackgroundModulation and depletion strategies of regulatory T cells (Tregs) constitute valid approaches in antitumor immunotherapy but suffer from severe adverse effects due to their lack of selectivity for the tumor-infiltrating (ti-)Treg population

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8e764f930f6b9dd6108bd2cf028b8f
https://jitc.bmj.com/content/9/2/e001749.full

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Abstract 1732: Investigation of the best therapeutic approach to target CCR8 expressed on tumor regulatory T cells to boost anti-tumor immune responses

Autor: Helena Van Damme, Jo A. Van Ginderachter, Pascal Merchiers, Heleen Roose, Elizabeth Allen, Bruno Dombrecht, Rosa Martín-Pérez, Damya Laoui

Publikováno v: Cancer Research. 81:1732-1732

The goal of this study was to investigate the therapeutic potential of targeting regulatory T cells (Treg) through CC motif chemokine receptor 8 (CCR8) and to determine the optimal mode of action for CCR8 targeting molecules to elicit anti-tumor immu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89c70761e628fc24ff8b0936cdde080e
https://doi.org/10.1158/1538-7445.am2021-1732

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Organoids from pituitary as a novel research model toward pituitary stem cell exploration

Autor: Benjamin Beck, Hugo Vankelecom, Hiroshi Uji-i, Matteo Boretto, Annelies Vennekens, Emma Laporte, Alizée Vercauteren Drubbel, Indra Van Zundert, Benoit Cox, Heleen Roose, Charlotte Nys, Hiroto Kobayashi

Publikováno v: Journal of Endocrinology, 240 (2
Journal of Endocrinology

The pituitary is the master endocrine gland, harboring stem cells of which the phenotype and role remain poorly characterized. Here, we established organoids from mouse pituitary with the aim to generate a novel research model to study pituitary stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0747a7cb170d10c6a1137c2b68dfa3a
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/303170

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Major depletion of SOX2(+) stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling

Autor: Matteo Boretto, Conny Gysemans, Benoit Cox, Heleen Roose, Annelies Vennekens, Hugo Vankelecom

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2+ cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571a807e41e98db88319ec799fa36b15
https://lirias.kuleuven.be/handle/123456789/604650

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An autophagy-driven pathway of ATP secretion supports the aggressive phenotype of BRAF(V600E) inhibitor-resistant metastatic melanoma cells

Autor: Abhishek D. Garg, Aleksandra M. Dudek-Peric, Hugo Vankelecom, Shaun Martin, Freya Mertens, Sofie Van Eygen, Seyma Demirsoy, Peter Vangheluwe, Patrizia Agostinis, Heleen Roose

The ingrained capacity of melanoma cells to rapidly evolve toward an aggressive phenotype is manifested by their increased ability to develop drug-resistance, evident in the case of vemurafenib, a therapeutic-agent targeting BRAF(V600E). Previous stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b879520a6a793f0a4a2c1237cb554987
http://www.tandfonline.com/doi/full/10.1080/15548627.2017.1332550

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