Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Helder, André"'
Autor:
Anders Kvanta, Nalini Rangaswamy, Karen Holopigian, Christine Watters, Nicki Jennings, Melissa S. H. Liew, Chad Bigelow, Cynthia Grosskreutz, Marie Burstedt, Abinaya Venkataraman, Sofie Westman, Asbjörg Geirsdottir, Kalliopi Stasi, Helder André
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Gene therapy holds promise for treatment of inherited retinal dystrophies, a group of rare genetic disorders characterized by severe loss of vision. Here, we report up to 3-year pre-specified interim safety and efficacy results of an open-la
Externí odkaz:
https://doaj.org/article/3edf795df36e4c739287664b808fdee1
Autor:
Azar Bakand, Sevil Vaghefi Moghaddam, Maryam Naseroleslami, Helder André, Neda Mousavi-Niri, Effat Alizadeh
Publikováno v:
Journal of Biological Engineering, Vol 17, Iss 1, Pp 1-21 (2023)
Abstract A number of molecular biofactors have been documented in pathogenesis and poor prognosis of colorectal cancer (CRC). Among them, the Hypoxia-Inducible Factor (HIF-1a) is frequently reported to become over-expressed, and its targeting could r
Externí odkaz:
https://doaj.org/article/f3a64c1d3b79486b96dc7449e0b9452a
Autor:
Tanzina Mollick, Suhas Darekar, Basile Dalarun, Flavia Plastino, Juan Zhang, Andres Pastor Fernández, Twana Alkasalias, Helder André, Sonia Laín
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23831- (2024)
Retinoblastoma is an eye cancer that commonly affects young children. Despite significant advances, current treatments cause side effects even when administered locally, and patients may still have to undergo enucleation. This is particularly dishear
Externí odkaz:
https://doaj.org/article/c582d86aa6a9459dbb5b0bce5058ee33
Autor:
Christina Herrspiegel, Flavia Plastino, Emma Lardner, Stefan Seregard, Pete A. Williams, Helder André, Gustav Stålhammar
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Purpose To develop a prognostic test based on a single blood sample obtained at the time of uveal melanoma diagnosis. Methods 83 patients diagnosed with posterior uveal melanoma between 1996 and 2000 were included. Peripheral serum samples w
Externí odkaz:
https://doaj.org/article/dfb5ef89f6d14bec8ec1dc4e25f047dc
Autor:
Philippe A. Melas, Malin Wirf, Helder André, Nitya Jayaram-Lindström, Aleksander A. Mathé, Pia Steensland
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated an
Externí odkaz:
https://doaj.org/article/f680823939044cf9a8a1a710b39fef5a
Autor:
Sandra Petrus‐Reurer, Pankaj Kumar, Sara Padrell Sánchez, Monica Aronsson, Helder André, Hammurabi Bartuma, Alvaro Plaza Reyes, Emeline F. Nandrot, Anders Kvanta, Fredrik Lanner
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 8, Pp 936-953 (2020)
Abstract As pluripotent stem cell (PSC)‐based reparative cell therapies are reaching the bedside, there is a growing need for the standardization of studies concerning safety of the derived products. Clinical trials using these promising strategies
Externí odkaz:
https://doaj.org/article/01aa0cf03b2844ae8af64cc230466355
Autor:
Alvaro Plaza Reyes, Sandra Petrus-Reurer, Sara Padrell Sánchez, Pankaj Kumar, Iyadh Douagi, Hammurabi Bartuma, Monica Aronsson, Sofie Westman, Emma Lardner, Helder André, Anna Falk, Emeline F. Nandrot, Anders Kvanta, Fredrik Lanner
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Whilst pigmentation has been used to identify retinal pigment epithelial (RPE) cells, surface markers for these cells remain unclear. Here, the authors define surface markers for the RPE including CD140b, which help produce hPSC-derived RPE cells at
Externí odkaz:
https://doaj.org/article/a87b6c42eab14b69bd24544416acca50
Autor:
Mooud Amirkavei, Flavia Plastino, Anders Kvanta, Kai Kaarniranta, Helder André, Ari Koskelainen
Publikováno v:
Cells, Vol 11, Iss 11, p 1778 (2022)
To maintain homeostasis, cells have evolved stress-response pathways to cope with exogenous and endogenous stress factors. Diverse stresses at high doses may be detrimental, albeit low doses of stress, known as hormesis, can be beneficial. Upon expos
Externí odkaz:
https://doaj.org/article/d63143acca3d462d9b424e15da73f0ec
Autor:
Ross O Smith, Takeshi Ninchoji, Emma Gordon, Helder André, Elisabetta Dejana, Dietmar Vestweber, Anders Kvanta, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 9 (2020)
Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include v
Externí odkaz:
https://doaj.org/article/9e7f759c6eb54ac3af3a03679e04ff12
Autor:
Álvaro Santana-Garrido, Claudia Reyes-Goya, Santiago Milla-Navarro, Pedro de la Villa, Helder André, Carmen M. Vázquez, Alfonso Mate
Publikováno v:
Foods, Vol 10, Iss 9, p 1993 (2021)
Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti-inflammatory
Externí odkaz:
https://doaj.org/article/cafd486b3664472eb3ab7ea38d5ea5a1