Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Helén L. Dichek"'
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 3, Pp 551-560 (2004)
Hepatic lipase clears plasma cholesterol by lipolytic and nonlipolytic processing of lipoproteins. We hypothesized that the nonlipolytic processing (known as the bridging function) clears cholesterol by removing apoB-48- and apoB-100-containing lipop
Externí odkaz:
https://doaj.org/article/0e6a836d43a14074942d77b537915f50
Autor:
Helén L. Dichek, Sarah M. Johnson, Hassibullah Akeefe, Giai T. Lo, Ezra Sage, Christine E. Yap, Robert W. Mahley
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 2, Pp 201-210 (2001)
To address the role of the noncatalytic ligand function of hepatic lipase (HL) in low density lipoprotein (LDL) receptor-mediated lipoprotein metabolism, we characterized transgenic mice lacking the LDL receptor (LDLR) that express either catalytical
Externí odkaz:
https://doaj.org/article/86df620c6d5e4779bff5513dace5a7b5
Autor:
Aaron S. Kelly, Elaine M. Urbina, Benjamin I. Goldstein, Amy S. Shah, Laurie Quinn, Kristen J. Nadeau, Stavroula K. Osganian, Pamela Martyn-Nemeth, Joseph T. Flynn, Sarah D. de Ferranti, David M. Maahs, Helén L. Dichek, Stephen R. Daniels
Publikováno v:
Circulation. 130:1532-1558
The rates of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are increasing in youth.1 In the past 10 years, guidelines for the identification and management of cardiovascular disease (CVD) risk factors in youth with diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c2fe85f19f939baa3e2a3161855c47
https://doi.org/10.1161/cir.0000000000000094
https://doi.org/10.1161/cir.0000000000000094
Autor:
Shan Wen, Rowan Flynn, Bo Jiang, Nagadhara Dronadula, Kun Qian, Chongren Tang, Joshua M Buckler, Helén L. Dichek, David A. Dichek
Publikováno v:
Molecular Therapy. 19:1833-1841
Expression of atheroprotective genes in the blood vessel wall is potentially an effective means of preventing or reversing atherosclerosis. Development of this approach has been hampered by lack of a suitable gene-transfer vector. We used a helper-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54651f6db66394836b75e02100dd8ddf
https://doi.org/10.1038/mt.2011.133
https://doi.org/10.1038/mt.2011.133
Autor:
Michal Kremen, Isaac Emery, Stephen A. Ramsey, David A. Dichek, Stephen D. Farris, Elizabeth S. Gold, Ranjini M. Krishnan, Helén L. Dichek, Talyn Chu, Jie Hong Hu, Liang Du
Publikováno v:
Journal of Biological Chemistry. 286:22665-22677
Data from clinical studies, cell culture, and animal models implicate the urokinase plasminogen activator (uPA)/uPA receptor (uPAR)/plasminogen system in the development of atherosclerosis and aneurysms. However, the mechanisms through which uPA/uPAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::008efea7d815eec15f8f1c73b90e8009
https://doi.org/10.1074/jbc.m110.202135
https://doi.org/10.1074/jbc.m110.202135
Autor:
Jie Hong Hu, Helén L. Dichek, Liang Du, Stephen D. Farris, Katherine I. Slezicki, Talyn Chu, Isaac Emery, David A. Dichek, Michal Kremen, Ranjini M. Krishnan
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 29:1737-1744
Objective— Enhanced plasminogen activation, mediated by overexpression of urokinase-type plasminogen activator (uPA), accelerates atherosclerosis in apolipoprotein E–null mice. However, the mechanisms through which uPA acts remain unclear. In add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61267225389de06e7ee6d4c1d513954d
https://doi.org/10.1161/atvbaha.109.195529
https://doi.org/10.1161/atvbaha.109.195529
Autor:
Caroline J. Pennington, Casilde Sesti, Liang Du, April Stempien-Otero, Dylan R. Edwards, Michael R. Preusch, Madeline Nieves-Cintrón, David A. Dichek, Andrew D. Frutkin, Helén L. Dichek, Daniel Minter, Mia Jaffe, Goro Otsuka, Julien C. Marie, Jie Hong Hu
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 29:1251-1257
Objective—Impairment of transforming growth factor (TGF)-β1 signaling accelerates atherosclerosis in experimental mice. However, it is uncertain whether increased TGF-β1 expression would retard atherosclerosis. The role of TGF-β1 in aneurysm for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc87cc5a1138042453a131a3dfad85d
https://doi.org/10.1161/atvbaha.109.186593
https://doi.org/10.1161/atvbaha.109.186593
Autor:
David E. Cummings, Samir S. Deeb, John D. Brunzell, David S. Weigle, Heather Carew, David Hollenback, Helén L. Dichek, Sasha Taleban
Publikováno v:
Metabolism. 57:1155-1161
Congenital generalized lipodystrophy type 1 (CGL-1) is characterized by an absence of adipose tissue and decreased serum leptin levels. Low leptin levels in CGL-1 support the claim that subjects are hypermetabolic and hyperphagic. The present study e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2658809c99108e0411da243bcdf2014c
https://doi.org/10.1016/j.metabol.2008.04.008
https://doi.org/10.1016/j.metabol.2008.04.008
Autor:
Kun Qian, Nalini Agrawal, Eun Yeung Gong, Stephen M. Eacker, Keesook Lee, Helén L. Dichek, Robert E. Braun
Publikováno v:
Molecular Endocrinology. 22:623-635
The male sex steroid, testosterone (T), is synthesized from cholesterol in the testicular Leydig cell under control of the pituitary gonadotropin LH. Unlike most cells that use cholesterol primarily for membrane synthesis, steroidogenic cells have ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00ea2843048047de748907fbda58f2f
https://doi.org/10.1210/me.2006-0534
https://doi.org/10.1210/me.2006-0534
Publikováno v:
Atherosclerosis. 195:66-74
Increased expression of catalytically inactive hepatic lipase (ciHL) lowers remnants and low-density lipoproteins (LDL) and may reduce atherosclerosis in mice lacking both LDLreceptors (LDLR) and murine (m) HL. However, in a previous study, ciHL expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b860983d656479185c6b291e5295c6
https://doi.org/10.1016/j.atherosclerosis.2006.12.002
https://doi.org/10.1016/j.atherosclerosis.2006.12.002