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The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism

Autor: van Ruiten, Marjon S., van Gent, Démi, Sedeño Cacciatore, Ángela, Fauster, Astrid, Willems, Laureen, Hekkelman, Maarten L., Hoekman, Liesbeth, Altelaar, Maarten, Haarhuis, Judith H.I., Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D., Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Nature Structural and Molecular Biology, 29(6), 586. Nature Publishing Group
Nature Structural & Molecular Biology

Cohesin structures the genome through the formation of chromatin loops and by holding together the sister chromatids. The acetylation of cohesin’s SMC3 subunit is a dynamic process that involves the acetyltransferase ESCO1 and deacetylase HDAC8. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a4ad905bb251d198d7cdaf99fef5ec
https://pubmed.ncbi.nlm.nih.gov/35710836

Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining

Autor: Francica, Paola, Mutlu, Merve, Blomen, Vincent A, Oliveira, Catarina, Nowicka, Zuzanna, Trenner, Anika, Gerhards, Nora M, Bouwman, Peter, Stickel, Elmer, Hekkelman, Maarten L, Lingg, Lea, Klebic, Ismar, van de Ven, Marieke, de Korte-Grimmerink, Renske, Howald, Denise, Jonkers, Jos, Sartori, Alessandro A, Fendler, Wojciech, Chapman, J Ross, Brummelkamp, Thijn, Rottenberg, Sven

Publikováno v: Franica, Paola; Mutlu, Merve; Blomen, Vincent A.; Oliveira, Catarina; Nowicka, Zuzanna; Trenner, Anika; Gerhards, Nora M.; Bouwman, Peter; Stickel, Elmer; Hekkelman, Maarten L.; Lingg, Lea; Klebic, Ismar; van den Ven, Marieke; de Korte-Grimmerink, Renske; Howald, Denise; Jonkers, Jos; Sartori, Alessandro A.; Fendler, Wojciech; Chapman, J. Ross; Brummelkamp, Thijn; ... (2020). Functional radiogenetic profiling implicates ERCC6L2 in non-homologous end joining. Cell reports, 32(8), p. 108068. Cell Press 10.1016/j.celrep.2020.108068
Cell Reports, 32(8), 108068
Cell Reports, Vol 32, Iss 8, Pp 108068-(2020)

Summary: Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage response genes and me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e326fd011ac35ef74bdebb6db7847d24
https://boris.unibe.ch/146234/2/Figure1.pdf

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