Zobrazeno 1 - 10
of 1 150
pro vyhledávání: '"Heinzinger, A."'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Prediction methods inputting embeddings from protein language models have reached or even surpassed state-of-the-art performance on many protein prediction tasks. In natural language processing fine-tuning large language models has become th
Externí odkaz:
https://doaj.org/article/6325d3166f6e48c89be154a695c6c202
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract The identification of protein binding residues helps to understand their biological processes as protein function is often defined through ligand binding, such as to other proteins, small molecules, ions, or nucleotides. Methods predicting b
Externí odkaz:
https://doaj.org/article/2b3dcdd6452b40dbbaff9693ba42b48b
Autor:
Heinzinger, Catherine M., Lapin, Brittany, Thompson, Nicolas R., Li, Yadi, Milinovich, Alex, May, Anna M., Pena Orbea, Cinthya, Faulx, Michael, Van Wagoner, David R., Chung, Mina K., Foldvary-Schaefer, Nancy, Mehra, Reena
Publikováno v:
In JACC: Clinical Electrophysiology September 2024 10(9):2074-2084
Autor:
Ivan Koludarov, Mariana Velasque, Tobias Senoner, Thomas Timm, Carola Greve, Alexander Ben Hamadou, Deepak Kumar Gupta, Günter Lochnit, Michael Heinzinger, Andreas Vilcinskas, Rosalyn Gloag, Brock A. Harpur, Lars Podsiadlowski, Burkhard Rost, Timothy N. W. Jackson, Sebastien Dutertre, Eckart Stolle, Björn M. von Reumont
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-27 (2023)
Abstract Background Venoms, which have evolved numerous times in animals, are ideal models of convergent trait evolution. However, detailed genomic studies of toxin-encoding genes exist for only a few animal groups. The hyper-diverse hymenopteran ins
Externí odkaz:
https://doaj.org/article/d4e819b6aea4481dbc47399220d9b769
Autor:
Ivan Koludarov, Tobias Senoner, Timothy N. W. Jackson, Daniel Dashevsky, Michael Heinzinger, Steven D. Aird, Burkhard Rost
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Three-finger toxins (3FTXs) are a functionally diverse family of toxins, apparently unique to venoms of caenophidian snakes. Although the ancestral function of 3FTXs is antagonism of nicotinic acetylcholine receptors, redundancy conferred by
Externí odkaz:
https://doaj.org/article/6575a48432e64e678e61c3d04a931b8f
Autor:
Elnaggar, Ahmed, Heinzinger, Michael, Dallago, Christian, Rihawi, Ghalia, Wang, Yu, Jones, Llion, Gibbs, Tom, Feher, Tamas, Angerer, Christoph, Steinegger, Martin, Bhowmik, Debsindhu, Rost, Burkhard
Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two auto-regressive models (
Externí odkaz:
http://arxiv.org/abs/2007.06225
Autor:
Margos, Gabriele, Hofmann, Markus, Casjens, Sherwood, Dupraz, Marlene, Heinzinger, Susanne, Hartberger, Christine, Hepner, Sabrina, Schmeusser, Mercy, Sing, Andreas, Fingerle, Volker, McCoy, Karen D.
Publikováno v:
In Infection, Genetics and Evolution November 2023 115
Autor:
Catherine M. Heinzinger, Nicolas R. Thompson, Alex Milinovich, Matheus Lima Diniz Araujo, Cinthya Pena Orbea, Nancy Foldvary‐Schaefer, Philippe Haouzi, Michael Faulx, David R. Van Wagoner, Mina K. Chung, Reena Mehra
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 22 (2023)
Background We leverage a large clinical cohort to elucidate sleep‐disordered breathing and sleep‐related hypoxia in incident atrial fibrillation (AF) development given the yet unclear contributions of sleep‐related hypoxia and pulmonary physiol
Externí odkaz:
https://doaj.org/article/295aac9c8a0f400cb84682165eb98148
Autor:
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Düzel, Gabriel Ziegler, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from hea
Externí odkaz:
https://doaj.org/article/3e1d5f4982d94dcfb401907b7983080b
Autor:
Nicola Bordin, Ian Sillitoe, Vamsi Nallapareddy, Clemens Rauer, Su Datt Lam, Vaishali P. Waman, Neeladri Sen, Michael Heinzinger, Maria Littmann, Stephanie Kim, Sameer Velankar, Martin Steinegger, Burkhard Rost, Christine Orengo
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A new protein domain classification protocol incorporating deep learning strategies for detecting sequence and structure similarities between domain is used to systematically study and analyse the predicted AlphaFold2 structural models for proteins o
Externí odkaz:
https://doaj.org/article/c077b0db693c4a798c9578aeecb33276