Zobrazeno 1 - 10
of 185
pro vyhledávání: '"Heinz-Herbert Fiebig"'
Autor:
Vincent Vuaroqueaux, Hans R. Hendriks, Hoor Al-Hasani, Anne-Lise Peille, Samayita Das, Heinz-Herbert Fiebig
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract MI-773 is a recently developed small-molecule inhibitor of the mouse double minute 2 (MDM2) proto-oncogene. Preclinical data on the anti-tumour activity of MI-773 are limited and indicate that tumour cell lines (CLs) with mutated TP53 are mo
Externí odkaz:
https://doaj.org/article/fa935edd769044dbbcb37ff0f6b1cc5a
Molecular Modes of Action of an Aqueous Nerium oleander Extract in Cancer Cells In Vitro and In Vivo
Autor:
Luay J. Rashan, Nadire Özenver, Joelle C. Boulos, Mona Dawood, Wynand P. Roos, Katrin Franke, Ioannis Papasotiriou, Ludger A. Wessjohann, Heinz-Herbert Fiebig, Thomas Efferth
Publikováno v:
Molecules, Vol 28, Iss 4, p 1871 (2023)
Cancer drug resistance remains a major obstacle in clinical oncology. As most anticancer drugs are of natural origin, we investigated the anticancer potential of a standardized cold-water leaf extract from Nerium oleander L., termed Breastin. The phy
Externí odkaz:
https://doaj.org/article/7cc8ee3d74db4551ba4c7fc7cdeb880e
Autor:
Vincent Vuaroqueaux, Alexandra Musch, Dennis Kobelt, Thomas Risch, Pia Herrmann, Susen Burock, Anne-Lise Peille, Marie-Laure Yaspo, Heinz-Herbert Fiebig, Ulrike Stein
Publikováno v:
Cancers, Vol 14, Iss 7, p 1749 (2022)
Metastasis-Associated in Colon Cancer 1 (MACC1) is a strong prognostic biomarker inducing proliferation, migration, invasiveness, and metastasis of cancer cells. The context of MACC1 dysregulation in cancers is, however, still poorly understood. Here
Externí odkaz:
https://doaj.org/article/6ee5678d459c4fe98fe4380cbfbcb808
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 316-322 (2014)
The marine natural product malevamide D from the cyanobacterium Symploca hydnoides was synthesized for the first time. The final peptide coupling linked the dolaisoleuine and dolaproine subunits. The phenyl group of malevamide D was also functionaliz
Externí odkaz:
https://doaj.org/article/47af49d0d8b44f4abc7b14ccb59779cd
Autor:
Gerhard Kelter, Armin Maier, Patrizia Diana, Girolamo Cirrincione, Virginia Spanò, Paola Barraja, Barbara Parrino, Anna Carbone, Heinz-Herbert Fiebig
Publikováno v:
Marine Drugs, Vol 11, Iss 3, Pp 643-654 (2013)
2,5-bis(3′-Indolyl)pyrroles, analogues of the marine alkaloid nortopsentin, were conveniently prepared through a three step procedure in good overall yields. Derivatives 1a and 1b exhibited concentration-dependent antitumor activity towards a panel
Externí odkaz:
https://doaj.org/article/f3dd1038506f4ec08099288a9432a97a
Autor:
Julia Schueler, Dagmar Wider, Kerstin Klingner, Gabrielle M Siegers, Annette M May, Ralph Wäsch, Heinz-Herbert Fiebig, Monika Engelhardt
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79939 (2013)
BackgroundWe systematically analyzed multiple myeloma (MM) cell lines and patient bone marrow cells for their engraftment capacity in immunodeficient mice and validated the response of the resulting xenografts to antimyeloma agents.Design and methods
Externí odkaz:
https://doaj.org/article/084d0622fa22403885cc394eda0e439b
Autor:
Gerhard Kelter, Daniel Steinbach, Venkata Badireenath Konkimalla, Tsuyoshi Tahara, Shigeru Taketani, Heinz-Herbert Fiebig, Thomas Efferth
Publikováno v:
PLoS ONE, Vol 2, Iss 8, p e798 (2007)
The anti-malarial artesunate also exerts profound anti-cancer activity. The susceptibility of tumor cells to artesunate can be enhanced by ferrous iron. The transferrin receptor (TfR) is involved in iron uptake by internalization of transferrin and i
Externí odkaz:
https://doaj.org/article/520aba67834f4518aafbd3ab8582be21
Autor:
Vincent Vuaroqueaux, Nadine Obier, Anne-Lise Peille, Daniel Feger, Katharina Schaich, Thomas Metz, Sebastian Dempe, Heinz-Herbert Fiebig, Jan Erik Ehlert
Publikováno v:
Cancer Research. 83:4895-4895
Drug-conjugates are an emerging class of anticancer agents combining the cytotoxic activity of highly potent chemotherapeutic agents with the target specificity of an antibody, a small molecule or a peptide ligand directed against a cancer-associated
Autor:
Vincent Vuaroqueaux, Isabella H. Wulur, Swee-Seong Wong, Manuel Landesfeind, Greg Donoho, Kerstin Klingner, Steven M. Bray, Han-Kwang Yang, Peter Bronsert, Anne-Lise Peille, Amit Aggarwal, Seong-Ho Kong, Woo Ho Kim, Bruno Zeitouni, Jason C. Ting, Christoph Reinhard, Nina Zanella, Heinz-Herbert Fiebig, Hyuk-Joon Lee
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)
Communications Biology
Communications Biology
Patient-derived xenografts (PDX) have emerged as an important translational research tool for understanding tumor biology and enabling drug efficacy testing. They are established by transfer of patient tumor into immune compromised mice with the inte
Publikováno v:
Marine Drugs
Marine Drugs, Vol 19, Iss 715, p 715 (2021)
Marine Drugs; Volume 19; Issue 12; Pages: 715
Marine Drugs, Vol 19, Iss 715, p 715 (2021)
Marine Drugs; Volume 19; Issue 12; Pages: 715
Chemical investigation of the ethyl acetate extract from the marine-derived Streptomyces sp. isolate B1848 resulted in three new isoquinolinequinone derivatives, the mansouramycins E–G (1a–3a), in addition to the previously reported mansouramycin