Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Heinz Hammer"'
Small molecule in situ resin capture provides a compound first approach to natural product discovery
Autor:
Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, Tadeusz F. Molinski, Paul R. Jensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes. Here we introduce Small Molecule In situ Resin Capture (SMIRC), a culture-independen
Externí odkaz:
https://doaj.org/article/7ba9d42708bb45c1a8547a7ae7e75601
Autor:
Aurélie H. Benfield, Felicitas Vernen, Reuben S.E. Young, Ferran Nadal-Bufí, Henry Lamb, Heinz Hammerlindl, David J. Craik, Helmut Schaider, Nicole Lawrence, Stephen J. Blanksby, Sónia Troeira Henriques
Publikováno v:
Pharmacological Research, Vol 207, Iss , Pp 107298- (2024)
Acquired drug resistance is the major cause for disease recurrence in cancer patients, and this is particularly true for patients with metastatic melanoma that carry a BRAF V600E mutation. To address this problem, we investigated cyclic membrane-acti
Externí odkaz:
https://doaj.org/article/50785ac1b6184083804b7912b18f5e8f
Autor:
Johannes Km Fakler, Andreas Roth, Jamila G Dinger, Christoph Josten Christiane Kerner, Karl-Heinz Hammer, Gabriela Aust, J黵gen Kratzsch
Publikováno v:
International Journal of Orthopaedics. 5:876-882
Autor:
Niels, Hammer, Robert, Möbius, Stefan, Schleifenbaum, Karl-Heinz, Hammer, Stefan, Klima, Justin S, Lange, Odette, Soisson, Dirk, Winkler, Thomas L, Milani
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 8, p e0136375 (2015)
PLoS ONE, Vol 10, Iss 8, p e0136375 (2015)
Introduction The sacroiliac joint (SIJ) is a common source of low back pain. However, clinical and functional signs and symptoms correlating with SIJ pain are widely unknown. Pelvic belts are routinely applied to treat SIJ pain but without sound evid
Autor:
Jake M. Bieber, Laura E. Sanman, Xiaoxiao Sun, Heinz Hammerlindl, Feng Bao, Maike A. Roth, Megan L. Koleske, Liusheng Huang, Fran Aweeka, Lani F. Wu, Steven J. Altschuler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Bieber et al use intestinal monolayers derived from fresh murine crypts as a model system to study drug toxicity. Testing 48 oncology drugs with known gastrointestinal toxicity as a proof of concept, they discover differential responses in cells from
Externí odkaz:
https://doaj.org/article/41ed1bb6411d4d969ca1025fa3f04d80
Publikováno v:
Wiener klinische Wochenschrift. 124
Exocrine pancreatic insufficiency in diabetic patients is frequent. Studies based on fecal elastase-1 measurement give prevalence rates of about 50 % in type 1 and 33 % in type 2 diabetic patients. Nevertheless, not all patients report typical sympto
Autor:
Niels Hammer, Robert Möbius, Stefan Schleifenbaum, Karl-Heinz Hammer, Stefan Klima, Justin S. Lange, Odette Soisson, Dirk Winkler, Thomas L. Milani
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140090 (2015)
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background A multitude of recent studies has observed common epigenetic changes develop in tumour cells of multiple lineages following exposure to stresses such as hypoxia, chemotherapeutics, immunotherapy or targeted therapies. A significan
Externí odkaz:
https://doaj.org/article/0431f52d0ab648aa83319c66c73b44d7
Autor:
Heinz Hammer
Dieses Therapielexikon gibt dem behandelnden Arzt eine unentbehrliche Hilfe für die tägliche Praxis an die Hand. Neben Therapie-Empfehlungen bei gastroenterologischen und hepatologischen Krankheitsbildern finden sich ausführliche Informationen zu
Autor:
Heinz Hammer, Ekkehard Winterfeldt
Publikováno v:
Tetrahedron. 37:3609-3613
Ring opening reactions of cyclopropane intermediates give rise to pentacyclic eburnamonines with a nitrogen or oxygen atom at position 15.