Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Heinz H. Osterburg"'
Autor:
Christopher P. Anderson, Heinz H. Osterburg, Bruce Teter, Irina Rozovsky, Caleb E. Finch, Knut Krohn
Publikováno v:
Glia. 17:195-205
The gene for glial fibrillary acidic protein (GFAP) was analyzed in the rat for developmental changes in methylation of cytosine at CpG sequences as a correlate of the onset of GFAP mRNA expression and for the effect of methylation on GFAP promoter a
Publikováno v:
Neuroendocrinology. 63:28-38
A novel cDNA clone, CR16, was isolated from a rat hippocampal cDNA library and characterized for responses to corticosteroids and regional expression. The 4-kb RNA was increased 3-fold by treatment of adrenalectomized (ADX) rats with corticosterone (
Autor:
Heinz H. Osterburg, Steven A. Johnson, Kurt Randerath, Kim L. Putman, Caleb E. Finch, David G. Morgan
Publikováno v:
Mutation Research/DNAging. 295:11-18
Brain DNA from 20 humans ranging in age from neonatal to 100 years was analyzed by the nuclease P1-enhanced version of the 32P-postlabeling assay for bulky covalently modified nucleotides. A reproducible pattern of three 32P-labeled spots was obtaine
Autor:
Caleb E. Finch, A.B. Kelly, Heinz H. Osterburg, Dave Morgan, Giulio Maria Pasinetti, John F. Reinhard, Steven G. Kohama, R.H. Stellwagen
Publikováno v:
Molecular Brain Research. 13:63-73
Slow neuron regression develops during the adult phase of life in select brain systems of mammals. We describe a model in adult rats that resolves several phases in a slow atrophic process that differentially influences levels of mRNA and protein for
Publikováno v:
Endocrinology. 130:805-810
The relative contributions of ovarian and extra-ovarian factors to the altered ovarian steroidal profiles of middle-aged mice were assessed by reciprocal, heterochronic ovarian grafting. Ovaries from cycling, young (2 months), and middle-aged (12 mon
Autor:
Tomiichiro Oda, Pat Wals, Heinz H. Osterburg, Steven A. Johnson, Giulio M. Pasinetti, Todd E. Morgan, Irina Rozovsky, W.Blaine Stine, Seth W. Snyder, Thomas F. Holzman, Grant A. Krafft, Caleb E. Finch
Publikováno v:
Experimental neurology. 136(1)
Clusterin (apoJ), a multifunctional apolipoprotein made by cells in the brain and many other locations, is associated with aggregated amyloid beta-peptide (A beta) in senile and diffuse plaques of Alzheimer's disease (AD). We observed that purified h
Publikováno v:
Journal of neuroscience research. 39(6)
The gene for glial fibrillary acidic protein (GFAP) was compared for CpG sites that are potential locations of methylated cytosine (mC). GFAP sequences in the 5′-upstream promoter and in exon 1 of rat, mouse, and human showed extensive similarity i
Autor:
Steven A. Johnson, Bruce Teter, Christopher P. Anderson, Heinz H. Osterburg, Nicholas J. Laping, J. P. O'Callaghan, Caleb E. Finch
Publikováno v:
Journal of neuroscience research. 39(6)
Age-related increases in the expression of glial fibrillary acidic protein (GFAP) in many brain regions are observed in short- and long-lived mammals. Possible genomic mechanisms for the increase of GFAP mRNA and protein were studied in the hippocamp
Autor:
Steven A. Johnson, Heinz H. Osterburg, Christopher P. Anderson, Tomiichiro Oda, Giulio Maria Pasinetti, Caleb E. Finch
Publikováno v:
Biochemical and biophysical research communications. 204(3)
Clusterin, a 70-80 kDa sulfated glycoprotein found in numerous tissues, is also known as complement lysis inhibitor (CLI), apolipoprotein J, SP-40,40, TRPM-2, and SGP-2. In Alzheimer disease (AD), clusterin mRNA is increased, whereas clusterin protei
Autor:
Heinz H. Osterburg, Nicholas J. Laping, Caleb E. Finch, Bon Hong Min, Jonathan R. Day, Glover Martin
Publikováno v:
Experimental neurology. 117(1)
Three new mRNA responses were found in the hippocampus of the adult male rat after entorhinal cortex lesions (ECL) that induce synaptic reorganization. Hippocampus cDNA libraries were screened by a subtractive hybridization strategy designed to detec