Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Heinz Goegelein"'
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 384(3)
Amiodarone is the "gold standard" for current antiarrhythmic therapy because it combines efficacy with good hemodynamic and electrophysiological tolerance. Amiodarone is effective against both atrial and ventricular arrhythmias by intravenous (i.v.)
Publikováno v:
Naunyn-Schmiedeberg's archives of pharmacology. 383(4)
Previous studies showed that amiodarone causes state-dependent inhibition of Na(+) channels thereby mediating an atrial-selective drug effect. The aim of the present study was to investigate the impact of the new antiarrhythmic compound dronedarone o
Autor:
Heinrich Christian Englert, Holger Heitsch, Hartung Jens, Heinz Goegelein, Uwe Gerlach, Mania Dieter, Sabine Scheidler
Publikováno v:
Journal of medicinal chemistry. 44(7)
Sulfonylthioureas exhibiting cardioselective blockade of ATP-sensitive potassium channels (K(ATP) channels) were discovered by stepwise structural variations of the antidiabetic sulfonylurea glibenclamide. As screening assays, reversal of rilmakalim-
Autor:
David R. Van Wagoner, Erik Harks, Laurie Castel, Ulrich Schotten, Michelle Lamorgese, Heinz Goegelein
Publikováno v:
Heart Rhythm. 2:S13-S14
Autor:
Heinz Goegelein, Marion Kuiper, Yuri Blaauw, Ulrich Schotten, Maurits A. Allessie, Arne van Hunnik, Sunniva de Haan
Publikováno v:
Heart Rhythm. 2:S181
Publikováno v:
Heart Rhythm. 2:S108
Background: Patients undergoing cardioversion of atrial tachyarrhythmias might benefit from positive inotropic stimulation of the atria. The shape of the atrial action potential (AP) is a major determinant of atrial contractility. Newly developed Ito