Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Heinz G. Linhart"'
Autor:
Felix Bormann, Manuel Rodríguez-Paredes, Felix Lasitschka, Dominic Edelmann, Tanja Musch, Axel Benner, Yehudit Bergman, Sebastian M. Dieter, Claudia R. Ball, Hanno Glimm, Heinz G. Linhart, Frank Lyko
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3407-3418 (2018)
Summary: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, prov
Externí odkaz:
https://doaj.org/article/e86c318f3a9a4f9bb5b8774c69ab0e1e
Autor:
Friederike Herbst, Hanno Glimm, Christian Rohde, Annika Krause, Carsten Müller-Tidow, Marina Scheller-Wendorff, Katja Hebestreit, Qiong Lin, Petra Tschanter, Nicole Bäumer, Wolfgang E. Berdel, Lucy A. Godley, Heinz G. Linhart, Martin Dugas, Wolfgang Wagner, Pia Riemke, Frank Rosenbauer, Isabell Schulze
Publikováno v:
Blood. 127:1575-1586
The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells. Dnmt3b has recently been shown to play a role in genic methylation. To investigate how Dnmt3b-mediated DNA methylation affects leukemogenesis,
Autor:
Günter Raddatz, Sebastian Bender, Daphne Cohen, Yehudit Bergman, Achim Breiling, Eli Pikarsky, Ihab Ansari, Heinz G. Linhart, Julian Gutekunst, Tanja Musch, Monther Abu-Remaileh, Frank Lyko
Publikováno v:
Cancer Research. 75:2120-2130
Chronic inflammation represents a major risk factor for tumor formation, but the underlying mechanisms have remained largely unknown. Epigenetic mechanisms can record the effects of environmental challenges on the genome level and could therefore pla
Autor:
Christian M. Zechmann, Frederik L. Giesel, Uwe Haberkorn, Ali Afshar-Oromieh, Tim Holland-Letz, Anna Malcher, Heinz G. Linhart, Jürgen Debus, Matthias Eder, Michael Eisenhut, Boris Hadaschik
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Positron emission tomography (PET) with choline tracers has found widespread use for the diagnosis of prostate cancer (PC). However, choline metabolism is not increased in a considerable number of cases, whereas prostate-specific membrane ant
Autor:
Tim Holland-Letz, Sabine Haufe, Clemens Kratochwil, Uwe Haberkorn, Christian M. Zechmann, Michael Eisenhut, F. L. Giesel, Matthias Eder, Heinz G. Linhart, Boris Hadaschik, Ali Afshar-Oromieh, A. Malcher
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 40:486-495
Purpose Prostate-specific membrane antigen (PSMA) is a cell surface protein with high expression in prostate carcinoma (PC) cells. Recently, procedures have been developed to label PSMA ligands with 68Ga, 99mTc and 123/124/131I. Our initial experienc
Autor:
Michael Eisenhut, Stephanie E. Combs, Frederik L. Giesel, Uwe Haberkorn, Ali Afshar-Oromieh, Dino Podlesek, Clemens Kratochwil, Sabine Haufe, Heinz G. Linhart
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 39:1409-1415
PET imaging with somatostatin receptor ligands, such as 68Ga-DOTATOC, is a well-established method for detection and target volume definition of meningiomas prior to radiotherapy. Since DOTATOC PET delivers a higher contrast between meningiomas and s
Autor:
Felix Lasitschka, Axel Benner, Hanno Glimm, Dominic Edelmann, Claudia R. Ball, Felix Bormann, Yehudit Bergman, Manuel Rodríguez-Paredes, Heinz G. Linhart, Frank Lyko
Publikováno v:
Cancer Research. 78:3305-3305
Introduction: Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and therefore p
Autor:
Witold Wolski, Hans-Joachim Mollenkopf, January Weiner, Ruedi Aebersold, Marco Iannaccone, Chandre Wagman, Heinz G. Linhart, Maria M. Esterhuyse, Stefan H. E. Kaufmann, Philippe Saikali, Etienne Caron, Kim Stanley, Gerhard Walzl, Andre G. Loxton, Matthias Schick
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
mBio
mBio, 6 (5)
mBio
mBio, 6 (5)
An estimated one-third of the world’s population is currently latently infected with Mycobacterium tuberculosis. Latent M. tuberculosis infection (LTBI) progresses into active tuberculosis (TB) disease in ~5 to 10% of infected individuals. Diagnost
Autor:
Yasuhiro Yamada, Konstantinos Meletis, Alexander Meissner, Suzanne Nguyen, Haijiang Lin, Laurie Jackson-Grusby, Heinz G. Linhart, Rudolf Jaenisch, Grace C. Lo
Publikováno v:
Molecular and Cellular Biology. 26:2976-2983
Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we d
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Colon polyps represent precursor lesions of colon cancers and their malignant potential varies according to histological subtype. A rare subtype of colon polyps is the Peutz–Jeghers (PJ) polyp. PJ polyps mostly occur in the context of Peutz–Jeghe