Management of patients with rare adult solid cancers: objectives and evaluation of European reference networks (ERN) EURACAN

Autor: Jean-Yves Blay, Paolo Casali, Isabelle Ray-Coquard, Michael J. Seckl, Jourik Gietema, Wouter W. de Herder, Martyn Caplin, Heinz-Josef Klümpen, Olivier Glehen, Lucjan Wyrwicz, Robin Peeters, Lisa Licitra, Nicolas Girard, Sophie Piperno-Neumann, Ellen Kapiteijn, Ahmed Idbaih, Enrico Franceschi, Annalisa Trama, Anna-Maria Frezza, Peter Hohenberger, Nadia Hindi, Javier Martin-Broto, Johanna Schell, Muriel Rogasik, Stephane Lejeune, Kathy Oliver, Francesco de Lorenzo, Ariane Weinman

Publikováno v: The Lancet Regional Health. Europe, Vol 39, Iss , Pp 100861- (2024)

Summary: About 500,000 patients with rare adult solid cancers (RASC) are diagnosed yearly in Europe. Delays and unequal quality of management impact negatively their survival. Since 2017, European reference networks (ERN) aim to improve the quality o

Externí odkaz: https://doaj.org/article/4f20025ebba2481ba272e65734dc8627

The genomic landscape of 85 advanced neuroendocrine neoplasms reveals subtype-heterogeneity and potential therapeutic targets

Autor: Job van Riet, Harmen J. G. van de Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. van Veenendaal, Heinz-Josef Klümpen, Marcus W. Dercksen, Gerlof D. Valk, Martijn P. Lolkema, Stefan Sleijfer, Bianca Mostert

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulati

Externí odkaz: https://doaj.org/article/c4e59c95fe6b477fbcc18e6c64953ba9

Invasive pneumococcal disease among adults with hematological and solid organ malignancies: A population-based cohort study

Autor: Hannah M. Garcia Garrido, Mirjam J. Knol, Jarom Heijmans, Nina M. van Sorge, Elisabeth A.M. Sanders, Heinz-Josef Klümpen, Martin P. Grobusch, Abraham Goorhuis

Publikováno v: International Journal of Infectious Diseases, Vol 106, Iss , Pp 237-245 (2021)

Objectives: To determine the risk of invasive pneumococcal disease (IPD) in adult cancer patients stratified by type of underlying malignancy, age, and capsular serotype and to assess herd effects of childhood pneumococcal vaccination. Methods: All a

Externí odkaz: https://doaj.org/article/993c8c8baff54f8a93d3d60ef2a0e8cb

Oncologic orphan drugs approved in the EU – do clinical trial data correspond with real-world effectiveness?

Autor: Yvonne Schuller, Marieke Biegstraaten, Carla E. M. Hollak, Heinz-Josef Klümpen, Christine C. Gispen-de Wied, Violeta Stoyanova-Beninska

Publikováno v: Orphanet Journal of Rare Diseases, Vol 13, Iss 1, Pp 1-11 (2018)

Abstract Background Evaluation of evidence for efficacy of orphan medicinal products (OMPs) for rare malignancies may be hampered by the use of tumor measurements instead of clinical endpoints. This may cause efficacy data to not always match effecti

Externí odkaz: https://doaj.org/article/54c1406d95344772a624b2f11cf50998

Long-term efficacy of metal versus plastic stents in inoperable perihilar cholangiocarcinoma; a multicenter retrospective propensity score matched comparison

Autor: Jeska A. Fritzsche, David M. de Jong, Jasmijn J.M.M. Borremans, Marco J. Bruno, Otto M. Van Delden, Joris I. Erdmann, Paul Fockens, Peter G.M. de Gooyer, Bas Groot Koerkamp, Heinz-Josef Klümpen, Adriaan Moelker, Nahid S.M. Montazeri, Lynn E. Nooijen, Cyriel Y. Ponsioen, Roy L.J. Van Wanrooij, Lydi M.J.W. van Driel, Rogier P. Voermans

Publikováno v: HPB. John Wiley and Sons Inc.
HPB, 25(7), 798-806. John Wiley & Sons Inc.
Fritzsche, J A, de Jong, D M, Borremans, J J M M, Bruno, M J, van Delden, O M, Erdmann, J I, Fockens, P, de Gooyer, P G M, Groot Koerkamp, B, Klümpen, H-J, Moelker, A, Montazeri, N S M, Nooijen, L E, Ponsioen, C Y, van Wanrooij, R L J, van Driel, L M J W & Voermans, R P 2023, ' Long-term efficacy of metal versus plastic stents in inoperable perihilar cholangiocarcinoma; a multicenter retrospective propensity score matched comparison ', HPB, vol. 25, no. 7, pp. 798-806 . https://doi.org/10.1016/j.hpb.2023.03.011

BACKGROUND: For palliative drainage of inoperable perihilar cholangiocarcinoma (pCCA) uncovered metal stents are preferred over plastic stents. However, there is a lack of data on re-interventions at the long-term. The aim is to evaluate the potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e5b0ae31367228cb6b13e57f2882c6
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