Zobrazeno 1 - 10
of 875
pro vyhledávání: '"Heinz, Wiendl"'
Autor:
Heinz Wiendl, John Foley, Gilles Defer, Lana Zhovtis Ryerson, Jeffrey A. Cohen, Douglas L. Arnold, Helmut Butzkueven, Gary R. Cutter, Gavin Giovannoni, Joep Killestein, Rose Domingo-Horne, Marie Toukam, Aimie Nunn, Amir-Hadi Maghzi, Robert Kuhelj, Tyler Lasky
Publikováno v:
Neurology and Therapy, Vol 13, Iss 5, Pp 1385-1401 (2024)
Abstract Introduction Following NOVA (part 1) and the approval of the subcutaneous (SC) route of administration of natalizumab by the European Medicines Agency, an extension phase of the NOVA phase IIIb study (part 2) was initiated to collect patient
Externí odkaz:
https://doaj.org/article/b321bac547dd4d7899d298075a610cb1
Autor:
Christine Dambietz, Michael Heming, Tobias J. Brix, Andreas Schulte-Mecklenbeck, Phil-Robin Tepasse, Catharina C. Gross, Jonel Trebicka, Heinz Wiendl, Gerd Meyer zu Hörste
Publikováno v:
BMC Neurology, Vol 24, Iss 1, Pp 1-19 (2024)
Abstract Cryptococcal meningitis (CM) is a severe fungal disease in immunocompromised patients affecting the central nervous system (CNS). Host response and immunological alterations in the cerebrospinal fluid (CSF) after invasion of Cryptococcus neo
Externí odkaz:
https://doaj.org/article/33ec184b3ce34f3fa8e275347fc6142b
Autor:
Julia Krämer, Carolin Balloff, Margit Weise, Valeria Koska, Yannik Uthmeier, Isabell Esderts, Mai Nguyen-Minh, Moritz Zimmerhof, Alex Hartmann, Michael Dietrich, Jens Ingwersen, John-Ih Lee, Joachim Havla, Tania Kümpfel, Martin Kerschensteiner, Vivien Häußler, Christoph Heesen, Jan-Patrick Stellmann, Hanna G. Zimmermann, Frederike C. Oertel, Marius Ringelstein, Alexander U. Brandt, Friedemann Paul, Orhan Aktas, Hans-Peter Hartung, Heinz Wiendl, Sven G. Meuth, Philipp Albrecht
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Retinal optical coherence tomography has been identified as biomarker for disease progression in relapsing-remitting multiple sclerosis (RRMS), while the dynamics of retinal atrophy in progressive MS are less clear. We investigated retinal l
Externí odkaz:
https://doaj.org/article/b623b81163fc45c78c872333e4b0d660
Autor:
Ali A. Habib, Sabrina Sacconi, Giovanni Antonini, Elena Cortés-Vicente, Julian Grosskreutz, Zabeen K. Mahuwala, Renato Mantegazza, Robert M. Pascuzzi, Kimiaki Utsugisawa, John Vissing, Tuan Vu, Heinz Wiendl, Marion Boehnlein, Bernhard Greve, Franz Woltering, Vera Bril
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Muscle-specific tyrosine kinase (MuSK) autoantibody-positive (Ab+) generalised myasthenia gravis (gMG) is a rare and frequently severe subtype of gMG. Objectives: To assess the efficacy and safety of rozanolixizumab in the subgroup of pat
Externí odkaz:
https://doaj.org/article/792b9660dfe54a3fafd21ea8a7d793f5
Autor:
I-Na Lu, Phyllis Fung-Yi Cheung, Michael Heming, Christian Thomas, Giovanni Giglio, Markus Leo, Merve Erdemir, Timo Wirth, Simone König, Christine A. Dambietz, Christina B. Schroeter, Christopher Nelke, Jens T. Siveke, Tobias Ruck, Luisa Klotz, Carmen Haider, Romana Höftberger, Christoph Kleinschnitz, Heinz Wiendl, Tim Hagenacker, Gerd Meyer zu Horste
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract 5q-associated spinal muscular atrophy (SMA) is a motoneuron disease caused by mutations in the survival motor neuron 1 (SMN1) gene. Adaptive immunity may contribute to SMA as described in other motoneuron diseases, yet mechanisms remain elus
Externí odkaz:
https://doaj.org/article/fb6284ab7fac4a1d86c729a732971fab
Autor:
Christine Anna Dambietz, Andrea Doescher, Michael Heming, Anja Schirmacher, Bernhard Schlüter, Andrea Schulte-Mecklenbeck, Christian Thomas, Heinz Wiendl, Gerd Meyer zu Hörste, Sarah Wiethoff
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: Pathogenic variants in the XK gene are associated with dysfunction or loss of XK protein leading to McLeod syndrome (MLS), a rare X-linked neuroacanthocytosis syndrome with multisystemic manifestation. Here we present clinical, genetic
Externí odkaz:
https://doaj.org/article/62589adcb151481b95104d243e2bc1fb
Autor:
Jeannette Lechner-Scott, Wenjia Wei, Heinz Wiendl, Xavier Montalban, Stephen L Hauser, Tjalf Ziemssen, Douglas L Arnold, Enrique Alvarez, Tobias Derfuss, Thomas P Leist, Alit Bhatt, Ibolya Boer
Publikováno v:
BMJ Neurology Open, Vol 6, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/2bf9db0e6f674b30b91492c0baf3b545
Autor:
Marios Antonakakis, Fabian Kaiser, Stefan Rampp, Stjepana Kovac, Heinz Wiendl, Walter Stummer, Joachim Gross, Christoph Kellinghaus, Maryam Khaleghi-Ghadiri, Gabriel Möddel, Carsten H. Wolters
Publikováno v:
Brain Stimulation, Vol 17, Iss 2, Pp 221-223 (2024)
Externí odkaz:
https://doaj.org/article/e602f89e6e3149be82512e65fce19465
Publikováno v:
BMJ Neurology Open, Vol 6, Iss 1 (2024)
Introduction Batoclimab, a fully human monoclonal antibody that inhibits the neonatal fragment crystallisable receptor, has shown promising phase 2 clinical trial results in patients with generalised myasthenia gravis (gMG).Methods and analysis In th
Externí odkaz:
https://doaj.org/article/c8d9d8ffed5b46a7bdc5bf1063ea521a
Autor:
Laura Airas, Robert A. Bermel, Tanuja Chitnis, Hans-Peter Hartung, Jin Nakahara, Olaf Stuve, Mitzi J. Williams, Bernd C. Kieseier, Heinz Wiendl
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Bruton’s tyrosine kinase (BTK) inhibitors are an emerging class of therapeutics in multiple sclerosis (MS). BTK is expressed in B-cells and myeloid cells, key progenitors of which include dendritic cells, microglia and macrophages, integral effecto
Externí odkaz:
https://doaj.org/article/e3efcb2e0b04417cb13665a1b2416894