Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Heinz, Scheuenstuhl"'
Autor:
Harriet W. Hopf, Farshid Farrahi, Heinz Scheuenstuhl, Thomas K. Hunt, S. Beckert, Alfred Königsrainer, Rummana Aslam
Publikováno v:
Wound Repair and Regeneration. 13:A28-A48
Introduction: Healing wounds are characterized by high lactate levels. In the past, the shift to an anaerobic energy metabolism was thought to be the main source for increased lactate concentration. Lactate is also generated by leukocytic NADPH-linke
Publikováno v:
Wound Repair and Regeneration. 13:A4-A27
Hypothesis: Both hypoxia and lactate independently induce VEGF synthesis. However, an adequate supply of oxygen is required for new vessels to mature. Materials and Methods: We used in vivo matrigel (growth factor reduced) angiogenesis assay and Swis
Autor:
Rummana Aslam, Farshid Farrahi, M. Zamirul Hussain, Stefan Beckert, Thomas K. Hunt, Alfred Königsrainer, Heinz Scheuenstuhl
Publikováno v:
Wound Repair and Regeneration. 14:321-324
The significance of the high lactate levels that characterize healing wounds is not fully understood. Lactate has been shown to enhance collagen synthesis by fibroblasts and vascular endothelial growth factor (VEGF) production by macrophages and endo
Autor:
Thomas K. Hunt, Horst D. Becker, M. Zamirul Hussain, Heinz Scheuenstuhl, Corinna Wicke, Odilo Trabold, Noah Rosen, Silvia Wagner, Alan Seremetiev
Publikováno v:
Wound Repair and Regeneration. 11:504-509
For many years, lactate has been known to accelerate collagen deposition in cultured fibroblasts and, without detailed explanation, has been presumed to stimulate angiogenesis. Similarly, hypoxia has been linked to angiogenic effects and collagen dep
Autor:
Hui Yuan, James S. Constant, David Y. Suh, Thomas K. Hunt, David D. Zabel, Heinz Scheuenstuhl, John J. Feng, M. Zamirul Hussain
Publikováno v:
Wound Repair and Regeneration. 8:353-360
Macrophages respond to various stimuli to produce angiogenic factors but few mechanistic details are known. We examined the effects of hypoxia, lactate and nicotinamide on the expression of vascular endothelial growth factor by cultured macrophages.
Publikováno v:
Journal of Surgical Research. 84:31-34
Targeted disruption of the stromelysin-1 gene in mice causes a delay in excisional wound healing due to a failure in wound contraction. Therefore, we postulated that stromelysin-1 activity is responsible for initiating contraction. To test this hypot
Autor:
Thomas K. Hunt, Mary Jo Tierney, Greg Hamon, Maxine A. Papadakis, E. Martin Spencer, Heinz Scheuenstuhl, Nancy A. Stotts
Publikováno v:
Wound Repair and Regeneration. 4:421-425
The secretion of growth hormone, an important anabolic agent, declines with aging. We hypothesize that growth hormone levels (measured as insulin-like growth factor-1) correlate with postoperative tissue repair in otherwise healthy, elderly persons.
Autor:
Heinz Scheuenstuhl, Albert Chan, Christian J. Gabka, Karen K. Fu, Thomas K. Hunt, Prosper Benhaim, Stephen J. Mathes
Publikováno v:
Plastic and Reconstructive Surgery. 96:1676-1688
Complications of irradiated tissue include infections and impaired healing. Although fibrosis and hypovascularity contribute, a cellular mechanism has not been identified. This study examines the effect of radiation (10 to 30 Gy) on neutrophil functi
Autor:
Harriet W. Hopf, Alison L. McKenzie, Joanne D. Whitney, Nancy N. Byl, Heinz Scheuenstuhl, Thomas K. Hunt, Judith M. West
Publikováno v:
Physical Therapy. 74:201-213
Background and Purpose. Microamperage direct current and microamperage electromagnetic stimulation are used to accelerate healing in bone. Although many clinicians are using microamperage stimulation to relieve pain and facilitate wound healing, ther
Autor:
Thomas K. Hunt, W H Goodson rd, Jensen Ja, Harriet W. Hopf, Judith M. West, Jonsson K, Heinz Scheuenstuhl
Publikováno v:
Scopus-Elsevier
Oxygen tension and collagen deposition were measured in standardized, subcutaneous wounds in 33 postoperative surgical patients. Pertinent clinical and wound parameters were analyzed by Pearson's correlation test and sequential linear regression anal