Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Heinz, Hillen"'
Autor:
Heinz Hillen
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/70b79ca707c9408590178da3e90a0ee9
Autor:
Heinz Hillen
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Beta amyloid, Aβ 1–42, originally named as Amyloid A4 protein, is one of the most investigated peptides in neuroscience and has attracted substantial interest since its discovery as the main insoluble fibril-type protein in cerebrovascular amyloid
Externí odkaz:
https://doaj.org/article/611e0c6a04384d44a14f7327419f1e38
Autor:
Gerald P. Gellermann, Helga Byrnes, Andreas Striebinger, Kathrin Ullrich, Reinhold Mueller, Heinz Hillen, Stefan Barghorn
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 2, Pp 212-220 (2008)
Soluble Aβ-oligomers are currently discussed as the major causative species for the development of Alzheimer's disease (AD). Consequently, the β-amyloid cascade hypothesis was extended by Aβ-oligomers and their central neuropathogenic role in AD.
Externí odkaz:
https://doaj.org/article/51c2a39a21a648f787f79d80a20ebc29
Autor:
Heinz Hillen
Die Menschheit steht vor großen Herausforderungen. Ein Weg aus der Misere sind wissenschaftliche Durchbrüche, die aber zunächst Forschung voraussetzen die, zumindest hierzulande, jedoch durchaus verbesserungswürdig ist. Heinz Hillen, erfolgreiche
Publikováno v:
Toxicologic Pathology. 44:474-479
Dogs have been often chosen as a nonrodent species for preclinical development of small molecule drugs mainly due to availability and relative ease of handling. Recently, focus has increased on the minipig as a potential alternative to the dog, based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de342cfd50cc340b9b100e7ddff2b7a
https://doi.org/10.1177/0192623315624572
https://doi.org/10.1177/0192623315624572
Autor:
Gerard B. Fox, Mark Day, Feng Luo, Ulrich Ebert, Vincent Hradil, Terese Seifert, Bryan F. Cox, Beate Roesner, Jean M. Severin, Heinz Hillen, Daniel A. Llano, Nathan R. Rustay
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:580-588
In recent years immunotherapy-based approaches for treating Alzheimer's disease have become the subject of intensive research. However, an important mechanistic-related safety concern is exacerbation of the risk of microhemorrhage that may be associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b13917328af39886dba23169e2206a
https://doi.org/10.1124/jpet.110.172932
https://doi.org/10.1124/jpet.110.172932
Autor:
Philip J. Hajduk, John E. Harlan, Ulrich Ebert, Robert W. Johnson, Stefan Barghorn, Larry R. Solomon, Thomas F. Holzman, Boris Labkovsky, Heinz Hillen, Edward T. Olejniczak, Rohinton Edalji, Karl A. Walter, Liping Yu, Paul L. Richardson, Laura J. Miesbauer, Diane Bartley, Ana Pereda Lopez
Publikováno v:
Biochemistry. 48:1870-1877
Alzheimer's disease (AD) is a neurodegenerative disorder that is linked to the presence of amyloid beta-peptides that can form insoluble fibrils or soluble oligomeric assemblies. Soluble forms are present in the brains and tissues of Alzheimer's pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457039242f221b4027522f6e3cf1430e
https://doi.org/10.1021/bi802046n
https://doi.org/10.1021/bi802046n
Autor:
Justin M. Carter, Ute Buerke, Karl Werdan, Michael Buerke, Martin Russ, Hansjörg Schwertz, Sebastian Schubert, Heinz Hillen, Axel Schlitt, Martin Schmidt
Publikováno v:
Journal of Cardiovascular Pharmacology. 52:151-160
Animal data strongly support a role for inflammation in myocardial ischemia reperfusion injury. Attempts at cardioprotection by immunomodulation (such as with the specific C5 antibody pexelizumab) in humans have been disappointing. We hypothesized th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a458be76ba37ba253a1f4c0b3645375
https://doi.org/10.1097/fjc.0b013e318180188b
https://doi.org/10.1097/fjc.0b013e318180188b
Autor:
Andreas Striebinger, Helga Byrnes, Heinz Hillen, Kathrin Ullrich, Reinhold Mueller, Gerald P. Gellermann, Stefan Barghorn
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 2, Pp 212-220 (2008)
Soluble A beta-oligomers are currently discussed as the major causative species for the development of Alzheimer's disease (AD). Consequently, the beta-amyloid cascade hypothesis was extended by A beta-oligomers and their central neuropathogenic role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023c10bec9f6257345471abceab96017
https://doi.org/10.1016/j.nbd.2008.01.010
https://doi.org/10.1016/j.nbd.2008.01.010
Autor:
Michael Bahr, Andreas Striebinger, Ulrich Ebert, John E. Harlan, Eve H. Barlow, Patrick Keller, Heinz Hillen, Carsten Krantz, Volker Nimmrich, Bodo Janson, Stefan Barghorn, Robert S. Bitner, Martin Schmidt
Publikováno v:
Journal of Neurochemistry. 95:834-847
Amyloid b-peptide (Ab)1)42 oligomers have recently been discussed as intermediate toxic species in Alzheimer’s disease (AD) pathology. Here we describe a new and highly stable Ab1)42 oligomer species which can easily be prepared in vitro and is pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64f5af21a80973eb18cd6911a3aecdef
https://doi.org/10.1111/j.1471-4159.2005.03407.x
https://doi.org/10.1111/j.1471-4159.2005.03407.x