Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Heintz, Robert M."'
Autor:
James R. Kiefer, Barta Thomas E, Heintz Robert M, Yvette M. Fobian, Daniel P. Becker, Grace E. Munie, Patrick B. Mullins, John M. Molyneaux, Brent V. Mischke, Darren J. Kassab, Louis J. Bedell, John N. Freskos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2823-2825
Continuing our interest in designing compounds preferentially potent and selective for MMP-13, we report on a series of hydroxamic acids with a flexible amide P1' substituents. We identify an amide which spares both MMP-1 and -14, and shows >500 fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64fc828c6eacfa443f80cdc71c9f154
https://doi.org/10.1016/j.bmcl.2011.03.095
https://doi.org/10.1016/j.bmcl.2011.03.095
Autor:
Geralyn P. Kocan, Heintz Robert M, Getman Daniel P, Deborah E. Bertenshaw, Mischke Brent, Christine Funckes-Shippy, Lisa W. Blystone, Martin L. Bryant, Nandini Kishore, Pramod P. Mehta, Kathyrn A. Houseman, John N. Freskos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:445-450
We have discovered a potent low molecular weight series of HIV-1 Protease inhibitors incorporating the (R)-(hydroxyethyl) sulfonamide isostere.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::261cd57af1b9ecc6c62f077147805e42
https://doi.org/10.1016/0960-894x(96)00035-2
https://doi.org/10.1016/0960-894x(96)00035-2
Autor:
Decrescenzo Gary A, J Marr, Mary Smidt, R Dillard, Heintz Robert M, Getman Daniel P, D Lansky, K Houseman, Michael Clare, Martin L. Bryant
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:2229-2234
SC-52151 is a potent, selective, tight-binding human immunodeficiency virus (HIV) protease inhibitor containing the novel (R)-(hydroxyethyl) urea isostere. The mean 50% effective concentration for lymphotropic, monocytotropic strains and field isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de628e860149087b8946c4f14905e95
https://doi.org/10.1128/aac.39.10.2229
https://doi.org/10.1128/aac.39.10.2229
Autor:
Shashidhar N. Rao, Francis J. Koszyk, Ish K. Khanna, Decrescenzo Gary A, Getman Daniel P, Janet Anne Julien, Richard M. Weier, Stealey Michael A, Heintz Robert M, Richard A. Mueller, Lydia Swenton
Publikováno v:
Journal of Carbohydrate Chemistry. 14:843-878
A useful methodology for the synthesis of a number of 2-, 3- and 2,3-disubstituted deoxynojirimycin analogs is reported. It has been found that the epoxides in stereoselectively synthesized N-carboalkoxy-2,3-anhydro-1-deoxymannojirimycins (4 and 5) r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97befdaa53d580da61e6afa663f24b01
https://doi.org/10.1080/07328309508005380
https://doi.org/10.1080/07328309508005380
Autor:
John J. Talley, J J Marr, Daniel P. Getman, Heintz Robert M, Kathryn Houseman, Michael Clare, Decrescenzo Gary A, Richard A. Mueller, M L Bryant, K.L. Reed
Publikováno v:
Journal of Medicinal Chemistry. 36:288-291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af990637934b2da714bfae5e50c9ac22
https://doi.org/10.1021/jm00054a014
https://doi.org/10.1021/jm00054a014
Autor:
Getman Daniel P, Shashidhar N. Rao, Francis Koszyk, J. Julien, L. Swenton, Richard Weier, Stealey Michael A, Decrescenzo Gary A, I. K. Khanna, Richard A. Mueller, Heintz Robert M
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e76bcd00f5ddded4f97944b50c6f8916
https://doi.org/10.1002/chin.199551251
https://doi.org/10.1002/chin.199551251
Autor:
Donna J. Paddock, Alfredo G. Tomasselli, John N. Freskos, Heintz Robert M, Brown David L, Thomas L. Emmons, Joseph B. Moon, Timothy E. Benson, Yvette M. Fobian, John M. Molyneaux, Alice Laborde, Greg Winterrowd, D. Bryan Prince, Brent V. Mischke, Joseph J. McDonald, Michael J. Bienkowski, Patrick B. Mullins
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(1)
We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1541d1cca9874f925ad126ae4a925af1
https://pubmed.ncbi.nlm.nih.gov/17049233
https://pubmed.ncbi.nlm.nih.gov/17049233
Autor:
Chris P. Carron, Craig Swearingen, Louis J. Bedell, John N. Freskos, Getman Daniel P, Clara I. Villamil, Grace E. Munie, Pramod P. Mehta, Boehm Terri L, Barta Thomas E, Madeleine H. Li, Daniel P. Becker, Susan L. Hockerman, Susan C. Howard, Heintz Robert M, Joseph J. McDonald, Chris L. Funckes-Shippy, Decrescenzo Gary A
Publikováno v:
Journal of medicinal chemistry. 48(21)
alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0539500154a05a00e3a097afebbcc7a1
https://pubmed.ncbi.nlm.nih.gov/16220987
https://pubmed.ncbi.nlm.nih.gov/16220987
Autor:
Dean Welsch, Craig Swearingen, Getman Daniel P, Joseph J. McDonald, Nandini Kishore, Shaukat H. Rangwala, Decrescenzo Gary A, Mischke Brent, Susan C. Howard, Grace E. Munie, Heintz Robert M, Charles Voliva, John N. Freskos
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(7)
We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a gamma-sulfone thiol.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a5e8490b5ac796c34d5a1450833ae40
https://pubmed.ncbi.nlm.nih.gov/10230616
https://pubmed.ncbi.nlm.nih.gov/10230616
Autor:
John J. Talley, Roderick A. Stegeman, Kathryn Houseman, Heintz Robert M, Decrescenzo Gary A, Daniel P. Getman, Richard A. Mueller, Vazquez Michael L, K.L. Reed, M.E. Gustafson, Michael Clare, Huey-Sheng Shieh, William C. Stallings, K.D. Junger
Publikováno v:
Acta Crystallographica Section A Foundations of Crystallography. 49:c156-c156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::999427e140a2093bb9418b920cbdfdf8
https://doi.org/10.1107/s0108767378095525
https://doi.org/10.1107/s0108767378095525