Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

Autor: Hendrikx, Tim, Porsch, Florentina, Kiss, Máté G., Rajcic, Dragana, Papac-Miličević, Nikolina, Hoebinger, Constanze, Goederle, Laura, Hladik, Anastasiya, Shaw, Lisa E., Horstmann, Hauke, Knapp, Sylvia, Derdak, Sophia, Bilban, Martin, Heintz, Lena, Krawczyk, Marcin, Paternostro, Rafael, Trauner, Michael, Farlik, Matthias, Wolf, Dennis, Binder, Christoph J.

Publikováno v: In Journal of Hepatology November 2022 77(5):1373-1385

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

Autor: Teo, Kevin, Abeysekera, Kushala WM, Adams, Leon, Aigner, Elmar, Anstee, Quentin M, Banales, Jesus M, Banerjee, Rajarshi, Basu, Priyadarshi, Berg, Thomas, Bhatnagar, Pallav, Buch, Stephan, Canbay, Ali, Caprio, Sonia, Chatterjee, Ankita, Ida Chen, Yii-Der, Chowdhury, Abhijit, Daly, Ann K, Datz, Christian, de Gracia Hahn, Dana, DiStefano, Johanna K, Dong, Jiawen, Duret, Amedine, EU-PNAFLD Investigators, Emdin, Connor, Fairey, Madison, Gerhard, Glenn S, GOLD Consortium, Guo, Xiuqing, Hampe, Jochen, Hickman, Matthew, Heintz, Lena, Hudert, Christian, Hunter, Harriet, Kelly, Matt, Kozlitina, Julia, Krawczyk, Marcin, Lammert, Frank, Langenberg, Claudia, Lavine, Joel, Li, Lin, Lim, Hong Kai, Loomba, Rohit, Luukkonen, Panu K, Melton, Phillip E, Mori, Trevor A, Palmer, Nicholette D, Parisinos, Constantinos A, Pillai, Sreekumar G, Qayyum, Faiza, Reichert, Matthias C, Romeo, Stefano, Rotter, Jerome I, Im, Yu Ri, Santoro, Nicola, Schafmayer, Clemens, Speliotes, Elizabeth K, Stender, Stefan, Stickel, Felix, Still, Christopher D, Strnad, Pavel, Taylor, Kent D, Tybjærg-Hansen, Anne, Umano, Giuseppina Rosaria, Utukuri, Mrudula, Valenti, Luca, Wagenknecht, Lynne E, Wareham, Nicholas J, Watanabe, Richard M, Wattacheril, Julia, Yaghootkar, Hanieh, Yki-Järvinen, Hannele, Young, Kendra A, Mann, Jake P

BACKGROUND & AIMS: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establ

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https://www.repository.cam.ac.uk/handle/1810/309561

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SAT-303-Liver fibrosis together with PNPLA3 p.I148M variant affects quality of life in patients with non-alcoholic fatty liver disease: prospective liver stiffness-based study.

Autor: Heintz, Lena, Holz, Robert, Weber, Susanne N, Lammert, Frank, Krawczyk, Marcin

Publikováno v: Journal of Hepatology. Apr2019 Supplement, Vol. 70, pe770-e771. 2p.

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis.

Autor: Teo K; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Abeysekera KWM; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Adams L; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia; Department of Hepatology, Sir Charles Gairdner Hospital, Perth, WA, Australia., Aigner E; First Department of Medicine, Paracelsus Medical University Salzburg, Austria., Anstee QM; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Newcastle NIHR Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Banales JM; Department on Liver and Gastrointestinal Diseases, Biodonostia Health Research Institute, Donostia University Hospital, University of the Basque Country (UPV/EHU), CIBERehd, Ikerbasque, San Sebastian, Spain., Banerjee R; Perspectum Ltd, Oxford, UK., Basu P; National Institute of Biomedical Genomics, Kalyani, India., Berg T; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany., Bhatnagar P; Eli Lilly and Company, Indianapolis, IN, USA., Buch S; Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany., Canbay A; Gastroenterology, Hepatology and Infectiology, Otto-von-Guericke University Magdeburg, Magdeburg, Germany., Caprio S; Yale University, Department of Pediatrics, New Haven, CT, USA., Chatterjee A; National Institute of Biomedical Genomics, Kalyani, India., Ida Chen YD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chowdhury A; Institute of Post Graduate Medical Education and Research, Kolkata, India., Daly AK; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Datz C; Department of Internal Medicine, General Hospital Oberndorf, Teaching Hospital of the Paracelsus Medical University Salzburg, Oberndorf, Austria., de Gracia Hahn D; School of Clinical Medicine, University of Cambridge, Cambridge, UK., DiStefano JK; Diabetes and Fibrotic Disease Unit Translational Genomics Research Institute (TGen), Phoenix, AZ, USA., Dong J; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Duret A; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Emdin C; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Boston, MA, USA., Fairey M; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Gerhard GS; Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Hampe J; Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany., Hickman M; MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK., Heintz L; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany., Hudert C; Department of Pediatric Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany., Hunter H; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Kelly M; Perspectum Ltd, Oxford, UK., Kozlitina J; Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA., Krawczyk M; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany; Laboratory of Metabolic Liver Diseases, Department of General, Transplant and Liver Surgery, Centre for Preclinical Research, Medical University of Warsaw, Warsaw, Poland., Lammert F; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lavine J; Department of Pediatrics, Columbia University, New York, NY, USA., Li L; BioStat Solutions LLC, Frederick, MD, USA., Lim HK; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Loomba R; NAFLD Research Center, Division of Gastroenterology and Epidemiology, University of California at San Diego, La Jolla, CA, USA., Luukkonen PK; Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Yale University School of Medicine, New Haven, CT, USA., Melton PE; School of Global Population Health, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, WA, Australia; School of Pharmacy and Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, WA, Australia; Menzies Institute for Medical Research, College of Health and Medicine, University of Tasmania, Hobart, Australia., Mori TA; Medical School, Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Parisinos CA; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, London, UK., Pillai SG; Eli Lilly and Company, Indianapolis, IN, USA., Qayyum F; Department of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Reichert MC; Department of Medicine II, Saarland University Medical Center, Saarland University, Homburg, Germany., Romeo S; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden; Cardiology Department, Sahlgrenska University Hospital, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Im YR; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Santoro N; Yale University, Department of Pediatrics, New Haven, CT, USA; Department of Medicine and Health Sciences 'V. Tiberio' University of Molise, Campobasso, Italy., Schafmayer C; Department of Visceral and Thoracic Surgery, Kiel University, Kiel, Germany., Speliotes EK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Michigan Health System, Ann Arbor, MI, USA; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA., Stender S; Department of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Stickel F; Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland., Still CD; Geisinger Obesity Institute, Danville, PA, USA., Strnad P; Medical Clinic III, University Hospital RWTH Aachen, Aachen, Germany., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Tybjærg-Hansen A; Department of Clinical Biochemistry, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Umano GR; Yale University, Department of Pediatrics, New Haven, CT, USA; Department of the Woman, the Child, of General and Specialized Surgery, University of Campania Luigi Vanvitelli, Naples, Italy., Utukuri M; School of Clinical Medicine, University of Cambridge, Cambridge, UK., Valenti L; Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano, Milan, Italy., Wagenknecht LE; Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Watanabe RM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wattacheril J; Department of Medicine, Center for Liver Disease and Transplantation, Columbia University College of Physicians and Surgeons, New York Presbyterian Hospital, New York, NY, USA., Yaghootkar H; Genetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, UK., Yki-Järvinen H; Minerva Foundation Institute for Medical Research, Helsinki, Finland; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Young KA; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA., Mann JP; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Electronic address: jm2032@cam.ac.uk.

Publikováno v: Journal of hepatology [J Hepatol] 2021 Jan; Vol. 74 (1), pp. 20-30. Date of Electronic Publication: 2020 Aug 31.