Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy.

Autor: Wang T; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Campbell C; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Stockdale AJ; Department of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Tropical Infectious Diseases Unit, Royal Liverpool Hospital, Liverpool University Hospitals NHS Trust, Liverpool, UK., Todd S; Tropical Infectious Diseases Unit, Royal Liverpool Hospital, Liverpool University Hospitals NHS Trust, Liverpool, UK., McIntyre K; Liverpool Clinical Laboratories, Liverpool University Hospitals NHS Trust, Liverpool, UK., Frankland A; Liverpool Clinical Laboratories, Liverpool University Hospitals NHS Trust, Liverpool, UK., Jaworski J; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Glampson B; iCARE Secure Data Environment, Digital Collaboration Space, Imperial College Healthcare NHS Trust, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Papadimitriou D; iCARE Secure Data Environment, Digital Collaboration Space, Imperial College Healthcare NHS Trust, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Mercuri L; iCARE Secure Data Environment, Digital Collaboration Space, Imperial College Healthcare NHS Trust, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Mayer E; iCARE Secure Data Environment, Digital Collaboration Space, Imperial College Healthcare NHS Trust, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK., Jones CR; Department of Surgery and Cancer, Imperial College London, London, UK.; Department of Infectious Disease, Imperial College London, London, UK., Salih H; NIHR Oxford Biomedical Research Centre, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Roadknight G; NIHR Oxford Biomedical Research Centre, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Little S; NIHR Oxford Biomedical Research Centre, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Noble T; NIHR Oxford Biomedical Research Centre, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Várnai KA; NIHR Oxford Biomedical Research Centre, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Davis C; Southampton Emerging Therapies and Technologies Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Clinical Informatics Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Heinson AI; Southampton Emerging Therapies and Technologies Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Clinical Informatics Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK., George M; Southampton Emerging Therapies and Technologies Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Clinical Informatics Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK., Borca F; Southampton Emerging Therapies and Technologies Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.; Clinical Informatics Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK., English L; NIHR University College London Hospitals Biomedical Research Centre, London, UK., Romão L; NIHR University College London Hospitals Biomedical Research Centre, London, UK., Ramlakhan D; NIHR University College London Hospitals Biomedical Research Centre, London, UK., Woods K; NIHR Oxford Biomedical Research Centre, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Davies J; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Department of Computer Science, University of Oxford, Oxford, UK., Nastouli E; Department of Infection, Immunity and Inflammation, UCL Great Ormond Street Institute of Child Health, London, UK.; Department of Virology, UCLH, London, UK., Khakoo SI; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Gelson W; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Cooke GS; iCARE Secure Data Environment, Digital Collaboration Space, Imperial College Healthcare NHS Trust, London, UK.; Department of Surgery and Cancer, Imperial College London, London, UK.; Faculty of Medicine, Department of Infectious Disease, Imperial College London, UK., Barnes E; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Matthews PC; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; NIHR Health Informatics Collaborative, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; The Francis Crick Institute, London, UK.; Division of Infection and Immunity, University College London, London, UK.; Department of Infectious Diseases, University College London Hospital, London, UK.

Publikováno v: JHEP reports : innovation in hepatology [JHEP Rep] 2024 Oct 09; Vol. 7 (1), pp. 101229. Date of Electronic Publication: 2024 Oct 09 (Print Publication: 2025).

Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD.

Autor: Hristova VA; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.; These authors contributed equally., Watson A; Faculty of Medicine, University of Southampton, Southampton, UK.; School of Clinical Medicine, University of Cambridge, Cambridge, UK.; These authors contributed equally., Chaerkady R; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Glover MS; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ackland J; Faculty of Medicine, University of Southampton, Southampton, UK., Angerman B; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Belfield G; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Belvisi MG; Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; NHLI, Imperial College, London, UK., Burke H; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK., Cellura D; Faculty of Medicine, University of Southampton, Southampton, UK., Clark HW; Neonatology, Faculty of Population Health Sciences, EGA Institute for Women's Health, University College London, London, UK.; NIHR University College London Hospital Biomedical Research, University College London Hospital, London, UK., Etal D; Translational Genomics, Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Freeman A; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK., Heinson AI; Faculty of Medicine, University of Southampton, Southampton, UK., Hess S; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hühn M; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Hall E; Faculty of Medicine, University of Southampton, Southampton, UK., Mackay A; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; NHLI, Imperial College, London, UK., Madsen J; Faculty of Medicine, University of Southampton, Southampton, UK., McCrae C; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, USA., Muthas D; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Novick S; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ostridge K; Faculty of Medicine, University of Southampton, Southampton, UK.; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Öberg L; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Platt A; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Postle AD; Faculty of Medicine, University of Southampton, Southampton, UK., Spalluto CM; Faculty of Medicine, University of Southampton, Southampton, UK., Vaarala O; Faculty of Medicine, University of Helsinki, Helsinki, Finland., Wang J; Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Staples KJ; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK., Wilkinson TMA; Faculty of Medicine, University of Southampton, Southampton, UK.; NIHR Southampton Biomedical Research Centre, University Hospital, Southampton, UK.

Publikováno v: ERJ open research [ERJ Open Res] 2022 May 15; Vol. 9 (3). Date of Electronic Publication: 2022 May 15 (Print Publication: 2023).

NERVE 2.0: boosting the new enhanced reverse vaccinology environment via artificial intelligence and a user-friendly web interface.

Autor: Conte, Andrea¹ (AUTHOR), Gulmini, Nicola¹ (AUTHOR), Costa, Francesco^1,2 (AUTHOR), Cartura, Matteo¹ (AUTHOR), Bröhl, Felix³ (AUTHOR), Patanè, Francesco¹ (AUTHOR), Filippini, Francesco¹ (AUTHOR) francesco.filippini@unipd.it

Publikováno v: BMC Bioinformatics. 12/18/2024, Vol. 25 Issue 1, p1-20. 20p.

An evaluation of different classification algorithms for protein sequence-based reverse vaccinology prediction.

Autor: Heinson AI; Faculty of Medicine University of Southampton, Southampton, United Kingdom., Ewing RM; Department of Biological Sciences University of Southampton, Southampton, United Kingdom., Holloway JW; Faculty of Medicine, University of Southampton, Southampton, United Kingdom., Woelk CH; Merck Exploratory Science Center, Cambridge, United States of America., Niranjan M; Department of Electronics and Computer Science, University of Southampton, Southampton, United Kingdom.

Publikováno v: PloS one [PLoS One] 2019 Dec 13; Vol. 14 (12), pp. e0226256. Date of Electronic Publication: 2019 Dec 13 (Print Publication: 2019).

Enhancing the Biological Relevance of Machine Learning Classifiers for Reverse Vaccinology.

Autor: Heinson AI; Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. a.heinson@soton.ac.uk., Gunawardana Y; Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. y.p.gunawardana@soton.ac.uk., Moesker B; Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. bastiaanmoesker@gmail.com., Hume CC; London School of Hygiene and Tropical Medicine (LSHTM), Department of Pathogen Molecular BiologyLondon WC1E 7HT, UK. carmen.denman@gmail.com., Vataga E; Solutions, University of Southampton, Southampton SO17 1BJ, UK. e.vataga@soton.ac.uk., Hall Y; Public Health England, National Infection Service, Porton Down Salisbury, SP4 0JG, UK. yper.hall@phe.gov.uk., Stylianou E; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK. elena.stylianou@ndm.ox.ac.uk., McShane H; The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK. helen.mcshane@ndm.ox.ac.uk., Williams A; Public Health England, National Infection Service, Porton Down Salisbury, SP4 0JG, UK. ann.rawkins@phe.gov.uk., Niranjan M; Department of Electronics and Computer Science, University of Southampton, Southampton SO17 1BJ, UK. mn@ecs.soton.ac.uk., Woelk CH; Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK. c.h.woelk@soton.ac.uk.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2017 Feb 01; Vol. 18 (2). Date of Electronic Publication: 2017 Feb 01.