The psychedelic drug DOI reduces heroin motivation by targeting 5-HT2A receptors in a heroin and alcohol co-use model.

Autor: Bonilla J; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Giannotti G; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA., Kregar NP; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Heinsbroek JA; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Olson DE; Department of Chemistry, University of California, Davis, Davis, CA, USA; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA; Center for Neuroscience, University of California, Davis, Davis, CA, USA; Institute for Psychedelics and Neurotherapeutics, University of California, Davis, Davis, CA, USA., Peters J; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: doctorj@uab.edu.

Publikováno v: Neuropharmacology [Neuropharmacology] 2024 Dec 15; Vol. 261, pp. 110163. Date of Electronic Publication: 2024 Sep 26.

Ca V 3.1 T-type calcium channels are important for spatial memory processing in the dorsal subiculum.

Autor: Joksimovic SM; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Division of Neurology and CHOP Research Institute, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ghodsi SM; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Heinsbroek JA; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Orfila JE; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, USA., Busquet N; Department of Neurology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Tesic V; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Valdez R; Department of Pediatrics, Division of Neurology, Translational Epilepsy Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Fine-Raquet B; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Jevtovic-Todorovic V; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Pharmacology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Raol YH; Department of Pediatrics, Division of Neurology, Translational Epilepsy Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; National Institute of Neurological Disorders and Stroke, National Institutes of Health, Rockville, MD, USA., Herson PS; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Department of Neurological Surgery, The Ohio State University College of Medicine, Columbus, OH, USA., Todorovic SM; Department of Anesthesiology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA; Neuroscience Graduate Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA. Electronic address: slobodan.todorovic@cuanschutz.edu.

Publikováno v: Neuropharmacology [Neuropharmacology] 2023 Mar 15; Vol. 226, pp. 109400. Date of Electronic Publication: 2022 Dec 29.

Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking.

Autor: Giannotti G; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA., Mottarlini F; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA.; Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133, Milan, Italy., Heinsbroek JA; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA., Mandel MR; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA., James MH; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, 08854, USA., Peters J; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA. jamie.l.peters@cuanschutz.edu.; Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO, 80045, USA. jamie.l.peters@cuanschutz.edu.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2022 Oct 04; Vol. 12 (1), pp. 432. Date of Electronic Publication: 2022 Oct 04.

Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors.

Autor: Gong S; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA., Fayette N; Department of Anesthesiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA., Heinsbroek JA; Department of Anesthesiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA., Ford CP; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: christopher.ford@cuanschutz.edu.

Publikováno v: Neuron [Neuron] 2021 Nov 03; Vol. 109 (21), pp. 3421-3435.e5. Date of Electronic Publication: 2021 Sep 09.

A common limiter circuit for opioid choice and relapse identified in a rodent addiction model.

Autor: Heinsbroek JA; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Giannotti G; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Mandel MR; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Josey M; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Aston-Jones G; Brain Health Institute, Rutgers University and Rutgers Biomedical and Health Sciences, Piscataway, NJ, USA., James MH; Brain Health Institute, Rutgers University and Rutgers Biomedical and Health Sciences, Piscataway, NJ, USA.; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ, USA., Peters J; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. jamie.l.peters@cuanschutz.edu.; Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. jamie.l.peters@cuanschutz.edu.

Publikováno v: Nature communications [Nat Commun] 2021 Aug 09; Vol. 12 (1), pp. 4788. Date of Electronic Publication: 2021 Aug 09.