Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Heinrich V. Malling"'
Autor:
Heinrich V. Malling
Publikováno v:
Mutation Research/Reviews in Mutation Research. 566:183-189
In the 1950's and 1960's it became obvious that many chemicals in daily use were mutagenic or carcinogenic, but there seemed to be little relation between the two activities. As scientists were debating the cause of this discrepancy, it was hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72ffbf39902a431044e7cb555bbbe78
https://doi.org/10.1016/j.mrrev.2003.11.003
https://doi.org/10.1016/j.mrrev.2003.11.003
Publikováno v:
Environmental and Molecular Mutagenesis. 42:258-273
Transgenic systems for measuring mammalian mutagenesis often use recoverable viral vectors. We hypothesize that mutations in these transgenic systems can arise from three different origins of DNA damage and replication errors and that these three ori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dace329ca0f9c17c035f0bf43c0bfd8
https://doi.org/10.1002/em.10195
https://doi.org/10.1002/em.10195
Autor:
Robert P. Weaver, Heinrich V. Malling
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 534:1-13
The am3 revertant frequencies (RF) in spleens from male mice transgenic for phiX174 am3 , cs70 were analyzed 14 weeks after ethylnitrosourea (ENU) treatment, both by the single burst assay (SBA) [1] and the mixed burst assay (MBA). The mean in vivo (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2927e9146796dafc40ce2bebff70aea0
https://doi.org/10.1016/s1383-5718(02)00242-5
https://doi.org/10.1016/s1383-5718(02)00242-5
Autor:
Robert R. Delongchamp, Beverly Montgomery, Scott G. Miller, Bentley A. Fane, Heinrich V. Malling, Carrie R. Valentine
Publikováno v:
Environmental and Molecular Mutagenesis. 39:55-68
The sensitivity of in vivo transgenic mutation assays benefits from the sequencing of mutations, although the large number of possible mutations hinders high throughput sequencing. A forward mutational assay exists for ΦX174 that requires an altered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d5575e868abbec317d15726cfbb831
https://doi.org/10.1002/em.10043
https://doi.org/10.1002/em.10043
Publikováno v:
Environmental and Molecular Mutagenesis. 37:356-360
In mutation assays using transgenic mice, with recoverable vectors such as PhiX174 am3, cs70, mutations originate from two sources: (1) in vivo mutations, that is, mutations that were fixed in the mouse, or (2) ex vivo mutations, that is, mutations t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541b9201ce754563c0fcbb76529d974b
https://doi.org/10.1002/em.1043
https://doi.org/10.1002/em.1043
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 444:85-95
Most cell divisions in the mouse brain have ceased by 14 days after birth. Therefore, spontaneous mutations that occur in brain cells can be assumed to be fixed by replication during brain development. Spontaneous and ethylnitrosourea (ENU)-induced r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eacc4a3b4f40e0afee07fc9b33900b05
https://doi.org/10.1016/s1383-5718(99)00088-1
https://doi.org/10.1016/s1383-5718(99)00088-1
Autor:
Robert P. Weaver, Heinrich V. Malling
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 412:271-281
Mutations induced in a single AT base pair were studied in spleen and testis by using mice transgenic for PhiX174 am3, cs70 and ethylnitrosourea (ENU) as the mutagen. The transgenic mice were produced on the C57BL6/J background. The line (am54), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98cd54c1382aead719b88ebdeaaf49b4
https://doi.org/10.1016/s1383-5718(97)00198-8
https://doi.org/10.1016/s1383-5718(97)00198-8
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 327:87-111
The mutagenicity of the trifunctional alkylating (or cross-linking) agent TEM (triethylenemelamine or 2,4,6-tris(1-aziridinyl)-1,3,5-triazine) in the adenine-3 (ad-3) region was studied with a two-component heterokaryon (H-12) of Neurospora crassa. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5affc103ceac3eb406a4dc72345090a8
https://doi.org/10.1016/0027-5107(94)00174-4
https://doi.org/10.1016/0027-5107(94)00174-4
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 310:15-36
The mutagenicity of the antitumor agent ICR-170 (2-methoxy-6-chloro-9-[(ethyl-2-chloroethyl)amino propylamino] acridine dihydrochloride) in the adenine-3 (ad-3) region was studied with a two-component heterokaryon (H-12) of Neurospora crassa. The obj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6936874d43e48a913d2d33d48d54eaf
https://doi.org/10.1016/0027-5107(94)90005-1
https://doi.org/10.1016/0027-5107(94)90005-1
Autor:
James G. Burkhart, Heinrich V. Malling
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 304:315-320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74273628bbfd5e1a178c83983c7432f
https://doi.org/10.1016/0027-5107(94)90226-7
https://doi.org/10.1016/0027-5107(94)90226-7