Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Heinrich Jasper"'
Autor:
Navid Nouri, Bailey Hannon Gussler, Amy Stockwell, Tom Truong, Gyeong Jin Kang, Kristen C. Browder, Yann Malato, Abdoulaye Sene, Sherri Van Everen, Charles C. Wykoff, David Brown, Arthur Fu, James D. Palmer, Jose Ronaldo Lima de Carvalho, Ehsan Ullah, Ranya Al Rawi, Emily Y. Chew, Wadih M. Zein, Bin Guan, Mark I. McCarthy, Jeffrey W. Hofmann, Shawnta Y. Chaney, Heinrich Jasper, Brian L. Yaspan
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Age-related macular degeneration (AMD), a complex neurodegenerative disease, is a leading cause of visual impairment worldwide with a strong genetic component. Genetic studies have identified several loci, but few causal genes with functiona
Externí odkaz:
https://doaj.org/article/ab0df09aee6145bab141375377878984
Autor:
Nadja S Katheder, Kristen C Browder, Diana Chang, Ann De Maziere, Pekka Kujala, Suzanne van Dijk, Judith Klumperman, Tzu-Chiao Lu, Hongjie Li, Zijuan Lai, Dewakar Sangaraju, Heinrich Jasper
Publikováno v:
eLife, Vol 12 (2023)
Disruption of epithelial barriers is a common disease manifestation in chronic degenerative diseases of the airways, lung, and intestine. Extensive human genetic studies have identified risk loci in such diseases, including in chronic obstructive pul
Externí odkaz:
https://doaj.org/article/ea91fa57d9b8465ea8754cb5229359f3
Autor:
Jina Yun, Simon Hansen, Otto Morris, David T. Madden, Clare Peters Libeu, Arjun J. Kumar, Cameron Wehrfritz, Aaron H. Nile, Yingnan Zhang, Lijuan Zhou, Yuxin Liang, Zora Modrusan, Michelle B. Chen, Christopher C. Overall, David Garfield, Judith Campisi, Birgit Schilling, Rami N. Hannoush, Heinrich Jasper
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration. Here the authors show that SASP factors impair regeneration, and that Ptk7 is
Externí odkaz:
https://doaj.org/article/0efe9bd563954738a88ecc378c67fcb4
Autor:
Arivazhagan Sambandam, Elaine Storm, Helen Tauc, Jason A. Hackney, David Garfield, Patrick Caplazi, John Liu, Juan Zhang, Hua Zhang, Jeff Duggan, Surinder Jeet, Sarah Gierke, Patrick Chang, Xiumin Wu, Robert Newman, Lucinda Tam, Tuija Alcantar, Lifen Wang, Meron Roose-Girma, Zora Modrusan, Wyne P. Lee, Heinrich Jasper, Frederic de Sauvage, Rajita Pappu
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e14238- (2023)
The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodeficiencies, m
Externí odkaz:
https://doaj.org/article/5f0b411f56a24ccdae5dfc7e215eea4e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Stem cell migration is critical during adult tissue regeneration. Here, the authors demonstrate that enteroendocrine cells coordinate stem cell migration towards sites of injury in the Drosophila intestine by activating non-canonical Wnt signaling.
Externí odkaz:
https://doaj.org/article/c22dd75450614573a27bc0d118fd971a
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102049- (2021)
Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy and the mitochondrial unfolded protein response (UPRmt) are the predominant stress-responsive and protective mechanisms involved in repairing damaged mitochondri
Externí odkaz:
https://doaj.org/article/9e2954702b354a7baa3a532fde6ef44d
Autor:
Evandro F. Fang, Yujun Hou, Sofie Lautrup, Martin Borch Jensen, Beimeng Yang, Tanima SenGupta, Domenica Caponio, Rojyar Khezri, Tyler G. Demarest, Yahyah Aman, David Figueroa, Marya Morevati, Ho-Joon Lee, Hisaya Kato, Henok Kassahun, Jong-Hyuk Lee, Deborah Filippelli, Mustafa Nazir Okur, Aswin Mangerich, Deborah L. Croteau, Yoshiro Maezawa, Costas A. Lyssiotis, Jun Tao, Koutaro Yokote, Tor Erik Rusten, Mark P. Mattson, Heinrich Jasper, Hilde Nilsen, Vilhelm A. Bohr
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
The molecular mechanisms of mitochondrial dysfunction in the premature ageing Werner syndrome were elusive. Here the authors show that NAD+ depletion-induced impaired mitophagy contributes to this phenomenon, shedding light on potential therapeutics.
Externí odkaz:
https://doaj.org/article/6fb6a8ffdc81475a8623958277a66533
Autor:
Jerome Korzelius, Sina Azami, Tal Ronnen-Oron, Philipp Koch, Maik Baldauf, Elke Meier, Imilce A. Rodriguez-Fernandez, Marco Groth, Pedro Sousa-Victor, Heinrich Jasper
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Notch signaling mediates intestinal enteroblast specification in Drosophila but the molecular mechanism as to how this is regulated is unclear. Here, the authors show that the transcription factor Klumpfuss ensures enteroblast commitment through repr
Externí odkaz:
https://doaj.org/article/c2a85d6a3b0f4b718c076a9ad8d66543
Autor:
Xiaoyu Tracy Cai, Hongjie Li, Abu Safyan, Jennifer Gawlik, George Pyrowolakis, Heinrich Jasper
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Regeneration after injury in the Drosophila intestine involves early activation of intestinal stem cells (ISCs) and subsequent return to quiescence. Here the authors show that return to quiescence by ISCs involves BMP Type I receptor Tkv protein stab
Externí odkaz:
https://doaj.org/article/af7a2653f02440a7a060265fa985a893
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Protein homeostasis maintenance (proteostasis) is critical for cell function, but declines during aging. Here the authors detail a proteostatic checkpoint in Drosophila intestinal stem cells coordinating cell cycle arrest with protein aggregate clear
Externí odkaz:
https://doaj.org/article/c91d0dc61d5447c88984735a68a69b99