Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Heinrich J.G. Matthies"'
Autor:
Freja Herborg, Kathrine L. Jensen, Sasha Tolstoy, Natascha V. Arends, Leonie P. Posselt, Aparna Shekar, Jenny I. Aguilar, Viktor K. Lund, Kevin Erreger, Mattias Rickhag, Matthew D. Lycas, Markus N. Lonsdale, Troels Rahbek-Clemmensen, Andreas T. Sørensen, Amy H. Newman, Annemette Løkkegaard, Ole Kjærulff, Thomas Werge, for the iPSYCH researchers, Lisbeth B. Møller, Heinrich J.G. Matthies, Aurelio Galli, Lena E. Hjermind, Ulrik Gether
Publikováno v:
JCI Insight, Vol 6, Iss 18 (2021)
Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related
Externí odkaz:
https://doaj.org/article/0e76e431d1f8444ba28610dba3786a03
Autor:
Etienne Cartier, Peter J. Hamilton, Andrea N. Belovich, Aparna Shekar, Nicholas G. Campbell, Christine Saunders, Thorvald F. Andreassen, Ulrik Gether, Jeremy Veenstra-Vanderweele, James S. Sutcliffe, Paula G. Ulery-Reynolds, Kevin Erreger, Heinrich J.G. Matthies, Aurelio Galli
Publikováno v:
EBioMedicine, Vol 2, Iss 2, Pp 135-146 (2015)
Background: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The DAT is a membrane p
Externí odkaz:
https://doaj.org/article/ce0d0f6e83244d4ab0050dafcac383f6
Autor:
Aparna Shekar, Andrea N Belovich, Samuel J. Mabry, Jenny I. Aguilar, Mary Hongying Cheng, Aurelio Galli, Heinrich J.G. Matthies, Daniele Zanella, Ivet Bahar, James D. Foster, Peter J. Hamilton, Daniel J. Stanislowski
Publikováno v:
Mol Psychiatry
Reward modulates the saliency of a specific drug exposure and is essential for the transition to addiction. Numerous human PET–fMRI studies establish a link between midbrain dopamine (DA) release, DA transporter (DAT) availability, and reward respo
Autor:
Kevin Erreger, Mattias Rickhag, Leonie P. Posselt, Aparna Shekar, Aurelio Galli, Troels Rahbek-Clemmensen, Markus Nowak Lonsdale, Sasha Tolstoy, Annemette Løkkegaard, Amy Hauck Newman, Natascha V. Arends, Andreas T. Sørensen, Thomas Werge, Viktor K. Lund, Lisbeth Birk Møller, Jenny I. Aguilar, Ulrik Gether, Kathrine L. Jensen, Lena Elisabeth Hjermind, Matthew D. Lycas, Ole Kjaerulff, Heinrich J.G. Matthies, Freja Herborg
Publikováno v:
JCI Insight
Herborg, F, Jensen, K L, Tolstoy, S, Arends, N, Posselt, L P, Shekar, A, Aguilar, J, Lund, V K, Erreger, K, Rickhag, M, Lycas, M D, Lonsdale, M N, Rahbek-Clemmensen, T, Sorensen, A T, Newman, A H, Lokkegaard, A, Kjaerulff, O, Werge, T, Moller, L B, Matthies, H J G, Galli, A, Hjermind, L E, Gether, U & IPSYCH Researchers 2021, ' Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease ', JCI insight, vol. 6, no. 18, 151496 . https://doi.org/10.1172/jci.insight.151496
Herborg, F, Jensen, K L, Tolstoy, S, Arends, N, Posselt, L P, Shekar, A, Aguilar, J, Lund, V K, Erreger, K, Rickhag, M, Lycas, M D, Lonsdale, M N, Rahbek-Clemmensen, T, Sorensen, A T, Newman, A H, Lokkegaard, A, Kjaerulff, O, Werge, T, Moller, L B, Matthies, H J G, Galli, A, Hjermind, L E, Gether, U & IPSYCH Researchers 2021, ' Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease ', JCI insight, vol. 6, no. 18, 151496 . https://doi.org/10.1172/jci.insight.151496
Dysfunctional dopaminergic neurotransmission is central to movement disorders and mental diseases. The dopamine transporter (DAT) regulates extracellular dopamine levels, but the genetic and mechanistic link between DAT function and dopamine-related
Autor:
Kaitlyn Ledwitch, Angela M. Carter, Jens Meiler, Samuel J. Mabry, Yanqi Zhu, Mary Hongying Cheng, Aurelio Galli, Josep Font, Andrea N Belovich, Hassane S. Mchaourab, Jenny I. Aguilar, Cristina Fenollar-Ferrer, Ivet Bahar, Amanda M. Duran, Heinrich J.G. Matthies, Renae M. Ryan, Alexandra C Schwartz, Manju A Kurian, Lei Shi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ae73e5f1109e0136609b9162f6010b
https://doi.org/10.7554/elife.68039.sa2
https://doi.org/10.7554/elife.68039.sa2
Autor:
Ramnarayan Ramachandran, Dungeng Peng, Jens Meiler, Brian J. O’Grady, Dongxue Yang, Aparna Shekar, Eric Gouaux, Jenny I. Aguilar, Greta Galli, Nicholas G. Campbell, Harald H. Sitte, Vikas Navratna, Aurelio Galli, James S. Sutcliffe, Heinrich J.G. Matthies, Amanda M. Duran, Thomas Stockner, Hassane S. Mchaourab, Kevin Erreger, Leon M. Bellan, Alexander N. Morley
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3853-3862
The human dopamine (DA) transporter (hDAT) mediates clearance of DA. Genetic variants in hDAT have been associated with DA dysfunction, a complication associated with several brain disorders, including autism spectrum disorder (ASD). Here, we investi
Autor:
Jens Meiler, Renae M. Ryan, Hassane S. Mchaourab, Andrea N Belovich, Amanda M. Duran, Manju A Kurian, Lei Shi, Yanqi Zhu, Alexandra C Schwartz, Josep Font, Heinrich J.G. Matthies, Aurelio Galli, Samuel J. Mabry, Kaitlyn Ledwitch, Angela M. Carter, Mary Hongying Cheng, Jenny I. Aguilar, Cristina Fenollar-Ferrer, Ivet Bahar
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Parkinson disease (PD) is a progressive, neurodegenerative disorder affecting over 6.1 million people worldwide. Although the cause of PD remains unclear, studies of highly-penetrant mutations identified in early-onset familial parkinsonism have cont
Autor:
Ulrik Gether, A. Loekkegaard, Andreas T. Sørensen, Natascha V. Arends, Aparna Shekar, Aurelio Galli, Freja Herborg, L. B. Moeller, Kenneth Jensen, Markus Nowak Lonsdale, Viktor K. Lund, Mattias Rickhag, Kevin Erreger, Amy Hauck Newman, Thomas Werge, Matthew D. Lycas, Ole Kjaerulff, S. Tolstoy, Jenny I. Aguilar, L. P. Posselt, Troels Rahbek-Clemmensen, Heinrich J.G. Matthies, Lena Elisabeth Hjermind
Dopaminergic dysfunction is central to movement disorders and mental diseases. The dopamine transporter (DAT) is essential for the regulation of extracellular dopamine but the genetic and mechanistic link between DAT function and dopamine-related pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af0f6e9d581a10325c3f789babc51d7b
https://doi.org/10.1101/2020.10.12.336461
https://doi.org/10.1101/2020.10.12.336461
Autor:
Heinrich J.G. Matthies, Alyssa West, Mark T. Wallace, Jenny I. Aguilar, Kyle E. Bundschuh, Fiona E. Harrison, Gabriella E. DiCarlo, Hao Chen, Freja Herborg, Ulrik Gether, Parastoo Hashemi, Mattias Rickhag, Aurelio Galli
Publikováno v:
DiCarlo, G E, Aguilar, J I, Matthies, H J G, Harrison, F E, Bundschuh, K E, West, A, Hashemi, P, Herborg, F, Rickhag, M, Chen, H, Gether, U, Wallace, M T & Galli, A 2019, ' Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors ', Journal of Clinical Investigation, vol. 129, no. 8, pp. 3407-3419 . https://doi.org/10.1172/JCI127411
The precise regulation of synaptic dopamine (DA) content by the dopamine transporter (DAT) ensures the phasic nature of the DA signal, which underlies the ability of DA to encode reward prediction error, thereby driving motivation, attention, and beh
Publikováno v:
The FASEB Journal. 32