Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Heinrich F. Bürgers"'
Publikováno v:
International Journal of Biological Sciences, Vol 4, Iss 1, Pp 1-7 (2008)
Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs).
Externí odkaz:
https://doaj.org/article/fa6edbff40d24ceaaa8f0abc4806294d
Publikováno v:
Journal of Veterinary Science
Genetically modified (GM) animals are unique mutants with an enormous scientific potential. Cryopreservation of pre-implantation embryos or spermatozoa is a common approach for protecting these lines from being lost or to store them in a repository.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a941bd64275818063aa33c5eab5820
http://europepmc.org/articles/PMC3467408
http://europepmc.org/articles/PMC3467408
Publikováno v:
Neurochemical Research. 35:1635-1642
Several questions concerning the survival of isolated neurons and neuronal stem and progenitor cells (NPCs) have not been answered in the past: (1) If lactate is discussed as a major physiological substrate of neurons, do neurons and NPCs survive in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbeda3c5b57d71012d0f91e71d548002
https://doi.org/10.1007/s11064-010-0224-1
https://doi.org/10.1007/s11064-010-0224-1
Autor:
Martin H. Maurer, Heinrich F. Bürgers, Carola Krüger, Bach Alfred, Dominik W. Schelshorn, Wolfgang Kuschinsky, Tanjew Dittgen, Armin Schneider, Fatemeh Sabouri, Nikolaus Gassler, Daniela Weber
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 29:585-595
Hemoglobin is the major protein in red blood cells and transports oxygen from the lungs to oxygen-demanding tissues, like the brain. Mechanisms that facilitate the uptake of oxygen in the vertebrate brain are unknown. In invertebrates, neuronal hemog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f36229b70fd461d75530a9bea124e46
https://doi.org/10.1038/jcbfm.2008.152
https://doi.org/10.1038/jcbfm.2008.152
Publikováno v:
The Open Enzyme Inhibition Journal. 1:5-11
Lithium is one of the standard drugs in the treatment of bipolar disorder, although its molecular modes of ac- tion are not well understood. It is a potent inhibitor of the multifunctional enzyme Glycogen Synthase Kinase 3s (GSK3s), which also plays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e27188a1a997c700c85bf51502f826
https://doi.org/10.2174/1874940200801010005
https://doi.org/10.2174/1874940200801010005
Autor:
Wolfgang Kuschinsky, H. Kenny Geomor, Dominik W. Schelshorn, Martin H. Maurer, Heinrich F. Bürgers
Publikováno v:
FEBS Letters. 580:4430-4434
In the brain, glucose is transported by GLUT1 across the blood–brain barrier and into astrocytes, and by GLUT3 into neurons. In the present study, the expression of GLUT1 and GLUT3 mRNA and protein was determined in adult neural stem cells cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1691719ebc5ce1252a6f522f1342f5
https://doi.org/10.1016/j.febslet.2006.07.012
https://doi.org/10.1016/j.febslet.2006.07.012
Blood–brain barrier (BBB) disruption, resulting from loss of tight junctions (TJ) and activation of matrix metalloproteinases (MMPs), is associated with edema formation in ischemic stroke. Cerebral edema develops in a phasic manner and consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a6f04526c4b375dcfa0f0f01319b63
https://europepmc.org/articles/PMC2949161/
https://europepmc.org/articles/PMC2949161/
Publikováno v:
International Journal of Biological Sciences
Growth factors are currently evaluated as therapeutics in stroke and neurodegeneration. Besides direct neurotrophic effects, they promote proliferation, survival, and differentiation of both transplanted and endogenous neural precursor cells (NPCs).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfca87a5ef0808ce1d02678311a19dd3
https://pubmed.ncbi.nlm.nih.gov/18167530
https://pubmed.ncbi.nlm.nih.gov/18167530
Autor:
Dominik W. Schelshorn, Anne Järve, Jens O. Brömme, Carola Krüger, Wolfgang Kuschinsky, Heinrich F. Bürgers, Armin Schneider, Martin H. Maurer, Robert E. Feldmann, Fatemeh Sabouri
Publikováno v:
Journal of proteome research. 6(3)
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3beta (GSK3beta) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772fb7062e3b294723042840ba7dd01b
https://pubmed.ncbi.nlm.nih.gov/17330951
https://pubmed.ncbi.nlm.nih.gov/17330951
Autor:
Patrick Wuchter, Rainer Saffrich, Martin H. Maurer, Frederik Wein, Robert E. Feldmann, Jonathon Blake, Anthony D. Ho, Heinrich F. Bürgers, Ulf Krause, Armin Kalenka, Wolfgang Wagner, Anja Seckinger, Wolfgang Kuschinsky
Publikováno v:
Experimental hematology. 34(4)
Objective Mesenchymal stem cells (MSC) raise high hopes in clinical applications. However, the lack of common standards and a precise definition of MSC preparations remains a major obstacle in research and application of MSC. Whereas surface antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb32c8b105088a6dd0097fed5e61434
https://pubmed.ncbi.nlm.nih.gov/16569600
https://pubmed.ncbi.nlm.nih.gov/16569600