Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Heini W. Dirr"'
Autor:
Sindisiwe G Buthelezi, Heini W Dirr, Ereck Chakauya, Rachel Chikwamba, Lennart Martens, Tsepo L Tsekoa, Elien Vandermarliere, Stoyan H Stoychev
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0209373 (2018)
Rabies is an ancient and neglected zoonotic disease caused by the rabies virus, a neurotropic RNA virus that belongs to the Rhabdoviridae family, genus Lyssavirus. It remains an important public health problem as there are cost and health concerns im
Externí odkaz:
https://doaj.org/article/e33cbb1eac7a426a9bd9c568aab01a61
Autor:
Tawanda Zininga, Ikechukwu Achilonu, Heinrich Hoppe, Earl Prinsloo, Heini W Dirr, Addmore Shonhai
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129445 (2015)
Six Hsp70-like genes are represented on the genome of Plasmodium falciparum. Of these two occur in the cytosol: P. falciparum Hsp70-z (PfHsp70-z) and PfHsp70-1. PfHsp70-1 is a well characterised canonical Hsp70 that facilitates protein quality contro
Externí odkaz:
https://doaj.org/article/4f45210f991543e68a48257195a258c1
Autor:
Heini W. Dirr, Alison Williams, Ikechukwu Achilonu, Yasien Sayed, Lynn Morris, Adriaan E. Basson
Publikováno v:
Biochemical Journal. 476:375-384
HIV protease is essential for processing the Gag polyprotein to produce infectious virions and is a major target in antiretroviral therapy. We have identified an unusual HIV-1 subtype C variant that contains insertions of leucine and asparagine (L38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f64932525013a457753ad38ee075036
https://doi.org/10.1042/bcj20180692
https://doi.org/10.1042/bcj20180692
Autor:
Arshad Ismail, Barton F. Haynes, Tandile Hermanus, Molati Nonyane, Lynn Morris, M. Anthony Moody, Heini W. Dirr, Valerie Bekker, Constantinos Kurt Wibmer, Salim S. Abdool Karim, Yasien Sayed, Balakrishnan Vijayakumar, Sherry Stanfield-Oakley, Nonhlanhla N. Mkhize, Lawrence Shapiro, Jinal N. Bhiman, Nigel Garrett, Batsirai Mabvakure, Zizhang Sheng, Penny L. Moore, Bronwen E. Lambson, Simone I. Richardson, Manuel A. Fernandes, Kevin Wiehe, Guido Ferrari, Charmaine. van Eeden, Cathrine Scheepers
Publikováno v:
Cell Reports, Vol 25, Iss 11, Pp 3123-3135.e6 (2018)
Cell reports
Cell reports
SUMMARY Antibodies that bind residue K169 in the V2 region of the HIV-1 envelope correlated with reduced risk of infection in the RV144 vaccine trial but were restricted to two ED-motif-encoding light chain genes. Here, we identify an HIV-infected do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2074b5e32949687ddbc40de989841d
http://www.sciencedirect.com/science/article/pii/S2211124718318345
http://www.sciencedirect.com/science/article/pii/S2211124718318345
Autor:
Roland Worth, Jessica Olfsen, Tshireletso Mentor, Sylvia Fanucchi, Yasien Sayed, Blessing O. Akumadu, Heini W. Dirr, Ramesh Pandian, Monare Thulo, Ikechukwu Achilonu
Publikováno v:
Molecular and biochemical parasitology. 240
Schistosoma japonicum glutathione transferase (Sj26GST), an enzyme central to detoxification of electrophilic compounds in the parasite, is upregulated in response to drug treatment. Therefore, Sj26GST may serve as a potential therapeutic target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489c848619397df6ea5b12c89e39967c
https://pubmed.ncbi.nlm.nih.gov/32961204
https://pubmed.ncbi.nlm.nih.gov/32961204
Autor:
Heini W. Dirr, Ikechukwu Achilonu, Lebogang Ramatsui, Blessing Mabate, Tawanda Zininga, Stanley Makumire, Addmore Shonhai
Publikováno v:
Proteins
Plasmodium falciparum, the main agent of malaria expresses six members of the heat shock protein 70 (Hsp70) family. Hsp70s serve as protein folding facilitators in the cell. Amongst the six Hsp70 species that P. falciparum expresses, Hsp70‐x (PfHsp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161fa2aa4fb55eb2a3af7bec24d6a831
https://doi.org/10.1002/prot.25600
https://doi.org/10.1002/prot.25600
Publikováno v:
The Protein Journal. 37:369-379
In recent years, various strategies have been used to overexpress and purify HIV-1 protease because it is an essential drug target in anti-retroviral therapy. Obtaining sufficient quantities of the enzyme, however, remains challenging. Overexpression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001df6fa9d12672de6201fe95e3431d9
https://doi.org/10.1007/s10930-018-9779-5
https://doi.org/10.1007/s10930-018-9779-5
Publikováno v:
Journal of Molecular Graphics and Modelling. 82:1-11
HIV-1 protease is an important antiretroviral drug target due to its key role in viral maturation. Computational models have been successfully used in the past to understand the dynamics of HIV-1 protease variants. We performed molecular dynamics sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3f2e4fd852ce6dce7585091989d632
https://doi.org/10.1016/j.jmgm.2018.03.006
https://doi.org/10.1016/j.jmgm.2018.03.006
Publikováno v:
The Protein Journal. 37:311-323
FOXP2 is a transcription factor expressed in multiple tissues during embryonic development. FOXP2 regulates transcription by binding to DNA at its DNA binding domain, the forkhead domain (FHD) through the recognition helix. Ser557 is a residue locate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d67843b3524712cebdd6aad71d850f
https://doi.org/10.1007/s10930-018-9777-7
https://doi.org/10.1007/s10930-018-9777-7
Publikováno v:
Journal of Molecular Structure. 1223:128892
The inhibition of the 26-kDa glutathione transferase from Schistosoma japonicum (Sj26GST) by bromosulfophthalein (BSP) and indanaloxyacetic acid-94 (IAA-94) was investigated using a systematic combination of empirical and theoretical approaches. Acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcedf0f9313575cf8a5104e3122acc1e
https://doi.org/10.1016/j.molstruc.2020.128892
https://doi.org/10.1016/j.molstruc.2020.128892