Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Heiner Schaal"'
Autor:
Maya Michon, Andreas Müller-Schiffmann, Anuradha F. Lingappa, Shao Feng Yu, Li Du, Fred Deiter, Sean Broce, Suguna Mallesh, Jackelyn Crabtree, Usha F. Lingappa, Amanda Macieik, Lisa Müller, Philipp Niklas Ostermann, Marcel Andrée, Ortwin Adams, Heiner Schaal, Robert J. Hogan, Ralph A. Tripp, Umesh Appaiah, Sanjeev K. Anand, Thomas W. Campi, Michael J. Ford, Jonathan C. Reed, Jim Lin, Olayemi Akintunde, Kiel Copeland, Christine Nichols, Emma Petrouski, Ana R. Moreira, I-ting Jiang, Nicholas DeYarman, Ian Brown, Sharon Lau, Ilana Segal, Danielle Goldsmith, Shi Hong, Vinod Asundi, Erica M. Briggs, Ngwe Sin Phyo, Markus Froehlich, Bruce Onisko, Kent Matlack, Debendranath Dey, Jaisri R. Lingappa, Dharma M. Prasad, Anatoliy Kitaygorodskyy, Dennis Solas, Homer Boushey, John Greenland, Satish Pillai, Michael K. Lo, Joel M. Montgomery, Christina F. Spiropoulou, Carsten Korth, Suganya Selvarajah, Kumar Paulvannan, Vishwanath R. Lingappa
Publikováno v:
Open Biology, Vol 14, Iss 6 (2024)
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative compound fr
Externí odkaz:
https://doaj.org/article/ab895c6ab92c405ab16479c74bcf64ea
Autor:
Lea Marie Esser, Katharina Schmitz, Frank Hillebrand, Steffen Erkelenz, Heiner Schaal, Björn Stork, Matthias Grimmler, Sebastian Wesselborg, Christoph Peter
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2100-2109 (2023)
The spliceosome, responsible for all mature protein-coding transcripts of eukaryotic intron-containing genes, consists of small uridine-rich nuclear ribonucleoproteins (UsnRNPs). The assembly of UsnRNPs depends, on one hand, on the arginine methylati
Externí odkaz:
https://doaj.org/article/104567e091404490bf1af5bf1619f414
Autor:
Helena Fabryova, Sandra Kao, Sayaka Sukegawa, Eri Miyagi, Louis Taylor, Damien Ferhadian, Hideki Saito, Heiner Schaal, Frank Hillebrand, Klaus Strebel
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Gelsolin (GSN) is a structural actin-binding protein that is known to affect actin dynamics in the cell. Using mass spectrometry, we identified GSN as a novel Vpr-interacting protein. Endogenous GSN protein was expressed at detectable levels
Externí odkaz:
https://doaj.org/article/81e9a9c32e914a9994936177ee01b3cb
Autor:
Lisa Müller, Marcel Andrée, Wiebke Moskorz, Ingo Drexler, Sandra Hauka, Johannes Ptok, Lara Walotka, Ramona Grothmann, Jonas Hillebrandt, Anastasia Ritchie, Laura Peter, Andreas Walker, Jörg Timm, Ortwin Adams, Heiner Schaal
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
We provide follow-up data on the humoral immune response after COVID-19 vaccinations of two distinct cohorts aged below 60 and over 80 years to screen for age-related differences in the longevity and magnitude of the induction of the antibody respons
Externí odkaz:
https://doaj.org/article/22f687e3b17c44a8a83efd4129099116
Autor:
Naghmeh Niktoreh, Lisa Weber, Christiane Walter, Mahshad Karimifard, Lina Marie Hoffmeister, Hannah Breiter, Aniththa Thivakaran, Maren Soldierer, Hans Günther Drexler, Heiner Schaal, Stephanie Sendker, Dirk Reinhardt, Markus Schneider, Helmut Hanenberg
Publikováno v:
Cancers, Vol 15, Iss 13, p 3491 (2023)
WT1 is a true chameleon, both acting as an oncogene and tumor suppressor. As its exact role in leukemogenesis is still ambiguous, research with model systems representing natural conditions surrounding the genetic alterations in WT1 is necessary. In
Externí odkaz:
https://doaj.org/article/3a72ceb6967b4651848ea9cd4edc2f0c
Autor:
Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as
Externí odkaz:
https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
Autor:
Johannes Ptok, Lisa Müller, Philipp Niklas Ostermann, Anastasia Ritchie, Alexander T. Dilthey, Stephan Theiss, Heiner Schaal
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3069-3076 (2021)
Codon degeneracy of amino acid sequences permits an additional “mRNP code” layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic strength and sequence context
Externí odkaz:
https://doaj.org/article/fd1dfa94fcef428e93ddfb76be1828f9
Autor:
Simon M. Hoser, Anne Hoffmann, Andreas Meindl, Maximilian Gamper, Jörg Fallmann, Stephan H. Bernhart, Lisa Müller, Melanie Ploner, Matthias Misslinger, Leopold Kremser, Herbert Lindner, Stephan Geley, Heiner Schaal, Peter F. Stadler, Alexander Huettenhofer
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-35 (2020)
Abstract Background The presence of nuclear mitochondrial DNA (numtDNA) has been reported within several nuclear genomes. Next to mitochondrial protein-coding genes, numtDNA sequences also encode for mitochondrial tRNA genes. However, the biological
Externí odkaz:
https://doaj.org/article/ef5cde895d3e494985b30d2192d76385
Autor:
Zhaoli Liu, Gizem Kilic, Wenchao Li, Ozlem Bulut, Manoj Kumar Gupta, Bowen Zhang, Cancan Qi, He Peng, Hsin-Chieh Tsay, Chai Fen Soon, Yonatan Ayalew Mekonnen, Anaísa Valido Ferreira, Caspar I. van der Made, Bram van Cranenbroek, Hans J. P. M. Koenen, Elles Simonetti, Dimitri Diavatopoulos, Marien I. de Jonge, Lisa Müller, Heiner Schaal, Philipp N. Ostermann, Markus Cornberg, Britta Eiz-Vesper, Frank van de Veerdonk, Reinout van Crevel, Leo A. B. Joosten, Jorge Domínguez-Andrés, Cheng-Jian Xu, Mihai G. Netea, Yang Li
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The majority of COVID-19 patients experience mild to moderate disease course and recover within a few weeks. An increasing number of studies characterized the long-term changes in the specific anti-SARS-CoV-2 immune responses, but how COVID-19 shapes
Externí odkaz:
https://doaj.org/article/7996e55ddd29440c90a66dc04e748775
Autor:
Lisa Müller, Marcel Andrée, Philipp Niklas Ostermann, Nathalie Jazmati, Greta Flüh, Johannes C. Fischer, Edwin Bölke, Eva Heger, Kanika Vanshylla, Florian Klein, Hilmar Wisplinghoff, Heiner Schaal, Ingo Drexler, Andreas Walker, Ortwin Adams, Jörg Timm
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Prophylactic vaccination against SARS-CoV-2 is one of the most important measures to contain the COVID-19 pandemic. Recently, break-through infections following vaccination against this virus have been reported. Here, we describe the humoral immune r
Externí odkaz:
https://doaj.org/article/4156753869454f42872b72dd7dd6974a