Výsledky vyhledávání

Ki-ras-Mutation als molekularer Tumormarker für Pankreaskarzinome

Autor: Georg Jacobs, Lorenz Trümper, B. Bürger, Kriener S, Michael Pfreundschuh, Heiner Daus, von Blohn G, Martin Zeitz

Publikováno v: DMW - Deutsche Medizinische Wochenschrift. 120:821-825

More than 90% of tumours of the pancreas have mutations on codon 12 of the Ki-ras oncogene. Cellular DNA from pancreatic secretions and fine-needle biopsies, obtained from 69 patients (41 men, 28 women), were amplified by the polymerase chain reactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc70a654ea802c0883a6c0035fddf3b3
https://doi.org/10.1055/s-2008-1055413

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MDM2 gene amplification and lack of p53 point mutations in Hodgkin and Reed-Sternberg cells: results from single-cell polymerase chain reaction and molecular cytogenetic studies

Autor: Frederike Von Bonin, Stefan Joos, Heiner Daus, Peter Lichter, Lorenz Trümper, Michael Pfreundschuh, Manfred Küpper

Publikováno v: British Journal of Haematology. 112:768-775

Hodgkin's disease (HD) is the most common haematological malignancy after chronic lymphocytic leukaemia, but very little is known about its pathogenesis or the genetic events that contribute to the malignant phenotype of the tumour cells. p53 is assu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7fd9db3145f49bd82e3557c886aed6c
https://doi.org/10.1046/j.1365-2141.2001.02566.x

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Enrichment polymerase chain reaction for the detection of Ki- ras mutations: relevance of Taq polymerase error rate, initial DNA copy number, and reaction conditions on the emergence of false-positive mutant bands

Autor: Alexandra Sek, Michael Pfreundschuh, Lorenz Trümper, Georg Jacobs, Heiner Daus, Elisabeth Tscholl

Publikováno v: Journal of Cancer Research and Clinical Oncology. 125:395-401

Screening for oncogene mutations as a marker for malignancy can be a powerful tool for the early diagnosis of cancer. The enrichment polymerase chain reaction (PCR) is a sensitive method for the detection of low-frequency mutations in small samples.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4356d47aff92a77fa835539258bc9df0
https://doi.org/10.1007/s004320050292

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Detection of the t(2;5)-associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals

Autor: Lorenz Trümper, Heiner Daus, F V Bonin, Michael Pfreundschuh

Publikováno v: British Journal of Haematology. 103:1138-1144

The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK on chromosome 2p23, is found in CD30+ anaplastic large cell lymphomas and some cases of B-cell lymphoma. Hodgkin's disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f64691027f7a2829ae154bdb2cc4833
https://doi.org/10.1046/j.1365-2141.1998.01097.x

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Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma

Autor: Michael Pfreundschuh, Heiner Daus, Nicole Fischer, Lorenz Trümper, Friedrich A. Grässer, Anja Mehl, Frank Hartmann, Martin Rowe, Nikolaus Muller-Lantzsch

Publikováno v: International Journal of Cancer. 76:194-200

Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b743290af035686fef01cd1298d5066a
https://doi.org/10.1002/(sici)1097-0215(19980413)76:2<194::aid-ijc5>3.0.co

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Lack of Evidence for a Pathogenic Role of Chlamydia pneumoniae and Cytomegalovirus Infection in Coronary Atheroma Formation

Autor: Dagmar Saage, Bruno Scheller, Michael Pfreundschuh, Cem Özbek, Heiner Daus, Angela Gause, Hermann Schieffer

Publikováno v: Cardiology. 90:83-88

Atherosclerotic cardiovascular disease is generally accepted to be the result of metabolic disturbances. However, recent studies have suggested an infectious agent, especially Chlamydia pneumoniae or cytomegalovirus, to be involved in the pathogenesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::796a5ff557a28f85fe2a1966dd4a31b4
https://doi.org/10.1159/000006824

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NPM/ALK fusion mRNA expression in Hodgkin and Reed-Sternberg cells is rare but does occur: Results from single-cell cDNA analysis

Autor: Alfred C. Feller, C. Cochlovius, Heiner Daus, Michael Pfreundschuh, Hartmut Merz, F. von Bonin, U. Loftin, Peter Möller, Lorenz Trümper

Publikováno v: Annals of Oncology. 8:S83-S87

Summary Background The translocation t(2;5)(p23;q35) leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the recently described receptor kinase ALK on 2p23. It is characteristic of a subgroup of CD30+ large-cell anaplastic non-H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f30117010a6e4f3aaa3660464826975a
https://doi.org/10.1093/annonc/8.suppl_2.s83

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Hodgkin and Reed-Sternberg cells do not carry T-cell receptor gamma gene rearrangements: evidence from single-cell polymerase chain reaction examination

Autor: Michael Pfreundschuh, Judith Roth, Lorenz Trümper, F von Bonin, A. Gause, Heiner Daus, P Moller

Publikováno v: Blood. 85:1590-1595

Hodgkin and Reed-Sternberg (H&RS) cells are generally accepted to be the neoplastic cells of Hodgkin's disease (HD), even though they represent only a minority of the cellular infiltrate in affected tissues. Recent immunologic studies and Southern bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0bc7f987d0ebc44ccc265a6a1b3816
https://doi.org/10.1182/blood.v85.6.1590.bloodjournal8561590

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Diagnosis of pancreatic adenocarcinoma by polymerase chain reaction from pancreatic secretions

Autor: G. von Blohn, Heiner Daus, B. Bürger, Michael Pfreundschuh, F. von Bonin, Lh H. Trümper, A. Hintze

Publikováno v: British Journal of Cancer

As mutations at codon 12 of the Ki-ras oncogene have been shown to occur in 90% of pancreatic adenocarcinomas, a novel strategy for the detection of these mutations in pancreatic secretions obtained at routine endoscopies was developed. Ki-ras DNA wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b002307f72fab88a90874ede3e47c2
https://doi.org/10.1038/bjc.1994.292

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