Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heiner Atze"'
Autor:
Heiner Atze, Yucheng Liang, Jean-Emmanuel Hugonnet, Arnaud Gutierrez, Filippo Rusconi, Michel Arthur
Publikováno v:
eLife, Vol 11 (2022)
Antibiotics of the β-lactam (penicillin) family inactivate target enzymes called D,D-transpeptidases or penicillin-binding proteins (PBPs) that catalyze the last cross-linking step of peptidoglycan synthesis. The resulting net-like macromolecule is
Externí odkaz:
https://doaj.org/article/e5c5599d78da4893b7c68c3799c81221
Publikováno v:
Organic Letters. 23:7755-7758
We explored the traceless Staudinger ligation for the functionalization of the C2 position of second generation β-lactamase inhibitors based on a diazabicyclooctane (DBO) scaffold. Our strategy is based on the synthesis of phosphine phenol esters an
Antibiotics of the β-lactam (penicillin) family inactivate target enzymes called D,D-transpeptidases or penicillin-binding proteins (PBPs) that catalyze the last cross-linking step of peptidoglycan synthesis. The resulting net-like macromolecule is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b9528cc787c32e94c5b9b0a53998ec9
https://doi.org/10.1101/2021.08.06.454924
https://doi.org/10.1101/2021.08.06.454924
Autor:
Mélanie Etheve-Quelquejeu, Fabrice Compain, Jean-Emmanuel Hugonnet, Michel Arthur, Adrian Dupuis, Laetitia Sutterlin, Clément Ourghanlian, Vincent Dubée, Sébastien Triboulet, Heiner Atze, Zainab Edoo
Publikováno v:
ACS Infectious Diseases. 5:1169-1176
In most bacteria, β-lactam antibiotics inhibit the last cross-linking step of peptidoglycan synthesis by acylation of the active-site Ser of D,D-transpeptidases belonging to the penicillin-binding protein (PBP) family. In mycobacteria, cross-linking
Autor:
Matthieu Fonvielle, Flavie Bouchet, Laura Iannazzo, Zainab Edoo, Mélanie Etheve-Quelquejeu, Heiner Atze, Michel Arthur
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, In press, ⟨10.1021/acs.jmedchem.9b02125⟩
Journal of Medicinal Chemistry, In press, ⟨10.1021/acs.jmedchem.9b02125⟩
Journal of Medicinal Chemistry, American Chemical Society, In press, ⟨10.1021/acs.jmedchem.9b02125⟩
Journal of Medicinal Chemistry, In press, ⟨10.1021/acs.jmedchem.9b02125⟩
Second-generation β-lactamase inhibitors containing a diazabicyclooctane (DBO) scaffold restore the activity of β-lactams against pathogenic bacteria, including those producing class A, C, and D enzymes that are not susceptible to first-generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7b9a6413efb7697f1916e9bcd6879b4
https://hal.archives-ouvertes.fr/hal-02565751/file/JMedChem2020-HAL.pdf
https://hal.archives-ouvertes.fr/hal-02565751/file/JMedChem2020-HAL.pdf
Publikováno v:
Journal of Antimicrobial Chemotherapy.
ObjectivesImipenem is one of the recommended β-lactams for the treatment of Mycobacterium abscessus pulmonary infections in spite of the production of BlaMab β-lactamase. Avibactam, a second-generation β-lactamase inhibitor, was previously shown t
Autor:
Ulrike Garscha, Antonietta Rossi, Daniela Schuster, Erik Romp, Veronika Temml, Christina Weinigel, Sandra K. Wittmann, Stefanie König, Jana Gerstmeier, Gerhard K. E. Scriba, Heiner Atze, Silke Rummler, Lidia Sautebin, Simona Pace, Markus Werner, Stefanie Liening, Oliver Werz
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
Arachidonic acid (AA) is metabolized to diverse bioactive lipid mediators. Whereas the 5-lipoxygenase-activating protein (FLAP) facilitates AA conversion by 5-lipoxygenase (5-LOX) to pro-inflammatory leukotrienes (LTs), the soluble epoxide hydrolase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8467a19d60608ed5b17c06cfbd12108f
http://hdl.handle.net/11588/684958
http://hdl.handle.net/11588/684958