Illuminati, a novel form of gene expression plasticity in Drosophila neural stem cells

Autor: Skorski P, Bardin A, Carole Pennetier, Lauzao A, Anthony Simon, Fabrizio Rossi, Alix Goupil, Cayetano Gonzalez, Heinen Jp, Salame R, Renata Basto

With the aim of developing a genetic instability (GI) sensor in vivo we used the well-established Gal80/Gal4-UAS system combined with a visual GFP marker in Drosophila. We generated a collection of 25 Drosophila lines carrying GAL80 transgenes in dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a94bfac5412e5863fc32ee0c9b5428
https://hal.archives-ouvertes.fr/hal-03453007

Human EWS-FLI protein levels and neomorphic functions show a complex, function-specific dose-response relationship in Drosophila .

Autor: Mahnoor S; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Molnar C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Velázquez D; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Reina J; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Llamazares S; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Heinen JP; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain., Mora J; Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain.; Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Gonzalez C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.

Publikováno v: Open biology [Open Biol] 2024 Jul; Vol. 14 (7), pp. 240043. Date of Electronic Publication: 2024 Jul 17.

Illuminati: a form of gene expression plasticity in Drosophila neural stem cells.

Autor: Goupil A; Institut Curie, Paris Science et Lettres Research University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche UMR144, Biology of Centrosomes and Genetic Instability Laboratory, 75005 Paris, France., Heinen JP; Institute for Research in Biomedicine (IRB Barcelona), Cell Division Laboratory, Cancer Science Programme, The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Salame R; Institut Curie, Paris Science et Lettres Research University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche UMR144, Biology of Centrosomes and Genetic Instability Laboratory, 75005 Paris, France., Rossi F; Institute for Research in Biomedicine (IRB Barcelona), Cell Division Laboratory, Cancer Science Programme, The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Reina J; Institute for Research in Biomedicine (IRB Barcelona), Cell Division Laboratory, Cancer Science Programme, The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Pennetier C; Institut Curie, Paris Science et Lettres Research University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche UMR144, Biology of Centrosomes and Genetic Instability Laboratory, 75005 Paris, France., Simon A; Institut Curie, Paris Science et Lettres Research University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche UMR144, Biology of Centrosomes and Genetic Instability Laboratory, 75005 Paris, France., Skorski P; Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Stem Cells and Tissue Homeostasis Group, 75005 Paris, France., Louzao A; Institute for Research in Biomedicine (IRB Barcelona), Cell Division Laboratory, Cancer Science Programme, The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Bardin AJ; Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Stem Cells and Tissue Homeostasis Group, 75005 Paris, France., Basto R; Institut Curie, Paris Science et Lettres Research University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche UMR144, Biology of Centrosomes and Genetic Instability Laboratory, 75005 Paris, France., Gonzalez C; Institute for Research in Biomedicine (IRB Barcelona), Cell Division Laboratory, Cancer Science Programme, The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain.; Catalan Institution for Research and Advanced Studies (ICREA), 08010 Barcelona, Spain.

Publikováno v: Development (Cambridge, England) [Development] 2022 Nov 15; Vol. 149 (22). Date of Electronic Publication: 2022 Nov 18.

Human EWS-FLI protein recapitulates in Drosophila the neomorphic functions that induce Ewing sarcoma tumorigenesis.

Autor: Molnar C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac 10, 08028 Barcelona, Spain., Reina J; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac 10, 08028 Barcelona, Spain., Herrero A; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac 10, 08028 Barcelona, Spain.; Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat 08950 Barcelona, Spain., Heinen JP; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac 10, 08028 Barcelona, Spain., Méndiz V; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac 10, 08028 Barcelona, Spain., Bonnal S; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain., Irimia M; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, 08003 Barcelona, Spain.; Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Pg Lluis Companys 23, 08010 Barcelona, Spain., Sánchez-Jiménez M; Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat 08950 Barcelona, Spain.; Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain., Sánchez-Molina S; Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat 08950 Barcelona, Spain.; Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain., Mora J; Developmental Tumor Biology Laboratory, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat 08950 Barcelona, Spain.; Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain., Gonzalez C; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Carrer Baldiri Reixac 10, 08028 Barcelona, Spain.; Institucio Catalana de Recerca i Estudis Avançats (ICREA), Pg Lluis Companys 23, 08010 Barcelona, Spain.

Publikováno v: PNAS nexus [PNAS Nexus] 2022 Oct 06; Vol. 1 (4), pp. pgac222. Date of Electronic Publication: 2022 Oct 06 (Print Publication: 2022).

An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth.

Autor: Rossi F; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Molnar C; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Hashiyama K; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Heinen JP; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Pampalona J; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Llamazares S; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Reina J; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Hashiyama T; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Rai M; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Pollarolo G; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Fernández-Hernández I; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain., Gonzalez C; Cell Division Group, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Baldiri Reixac, 10, 08028 Barcelona, Spain gonzalez@irbbarcelona.org.; Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys, 08010 Barcelona, Spain.

Publikováno v: Open biology [Open Biol] 2017 Aug; Vol. 7 (8).