Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Hein Te Riele"'
Autor:
Govind Pai, Khashayar Roohollahi, Davy Rockx, Yvonne de Jong, Chantal Stoepker, Charlotte Pennings, Martin Rooimans, Lianne Vriend, Sander Piersma, Connie R. Jimenez, Renee X. De Menezes, Victor W. Van Beusechem, Ruud H. Brakenhoff, Hein Te Riele, Rob M. F. Wolthuis, Josephine C. Dorsman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A genome-wide siRNA screen on patient-derived Fanconi anemia pathway-deficient head-and-neck squamous-cell-carcinoma (HNSCC) cell lines identifies RBBP9 as a candidate therapeutic target.
Externí odkaz:
https://doaj.org/article/d4abaadf82fc4ce89a966aaa06a906bf
Autor:
Tim J. W. Harmsen, Colin E. J. Pritchard, Joey Riepsaame, Henri J. van de Vrugt, Ivo J. Huijbers, Hein te Riele
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Promiscuous activity of the Streptococcus pyogenes DNA nuclease CRISPR-Cas9 can result in destruction of a successfully modified sequence obtained by templated repair of a Cas9-induced DNA double-strand break. To avoid re-cutting, additional
Externí odkaz:
https://doaj.org/article/5a302beab37f4b3db70dfe7a0b5f39e5
Autor:
Wietske Pieters, Floor Hugenholtz, Kevin Kos, Maxime Cammeraat, Teddy C. Moliej, Daphne Kaldenbach, Sjoerd Klarenbeek, Mark Davids, Lisa Drost, Charlotte de Konink, Elly Delzenne-Goette, Karin E. de Visser, Hein te Riele
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC), but it is largely unknown how the microbiota affects the pathogenesis of mismatch-repair-deficient CRC in the context of Lynch syndrome. In a mouse model for Lyn
Externí odkaz:
https://doaj.org/article/ea7cde7a89e14a07858878eb822c53b1
Autor:
Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to pati
Externí odkaz:
https://doaj.org/article/d3b40c6ab0ea4445955311ad736bc6e4
Autor:
Janne J. M. van Schie, Atiq Faramarz, Jesper A. Balk, Grant S. Stewart, Erika Cantelli, Anneke B. Oostra, Martin A. Rooimans, Joanna L. Parish, Cynthia de Almeida Estéves, Katja Dumic, Ingeborg Barisic, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mohammad Mahtab, Francesca M. Pisani, Hein te Riele, Najim Ameziane, Rob M. F. Wolthuis, Job de Lange
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Externí odkaz:
https://doaj.org/article/d1dd653aad8b4232927aa9fceeb46e31
Autor:
Luiza S. E. P. Will Castro, Wietske Pieters, Mir Farshid Alemdehy, Muhammad A. Aslam, Olimpia Alessandra Buoninfante, Jonne A. Raaijmakers, Bas Pilzecker, Paul C. M. van den Berk, Hein te Riele, René H. Medema, Rozangela C. Pedrosa, Heinz Jacobs
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we
Externí odkaz:
https://doaj.org/article/9e76e3ae24f2402f8606460ae34df061
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009041 (2020)
Through transfection of short single-stranded oligodeoxyribonucleotides (ssODNs) small genomic alterations can be introduced into mammalian cells with high precision. ssODNs integrate into the genome during DNA replication, but the resulting heterodu
Externí odkaz:
https://doaj.org/article/6eb274cca1854357a90cfb1c141016cf
Autor:
Bente Benedict, Tanja van Harn, Marleen Dekker, Simone Hermsen, Asli Kucukosmanoglu, Wietske Pieters, Elly Delzenne-Goette, Josephine C Dorsman, Eva Petermann, Floris Foijer, Hein te Riele
Publikováno v:
eLife, Vol 7 (2018)
In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, we found an unanticipated effect of p53 loss in mouse and
Externí odkaz:
https://doaj.org/article/d4318b7914644365b26606eeeb40b4fe
Autor:
Camiel L C Wielders, Pim van Nierop, Tinke L Vormer, Floris Foijer, Joanne Verheij, Johannes C Lodder, Jesper B Andersen, Huibert D Mansvelder, Hein Te Riele
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196979 (2018)
To identify coding and non-coding suppressor genes of anchorage-independent proliferation by efficient loss-of-function screening, we have developed a method for enzymatic production of low complexity shRNA libraries from subtracted transcriptomes. W
Externí odkaz:
https://doaj.org/article/dce58a605b1c4907943e5f0aefa893fa
Loss of photoreceptorness and gain of genomic alterations in retinoblastoma reveal tumor progression
Autor:
Irsan E. Kooi, Berber M. Mol, Annette C. Moll, Paul van der Valk, Marcus C. de Jong, Pim de Graaf, Saskia E. van Mil, Antoinette Y.N. Schouten-van Meeteren, Hanne Meijers-Heijboer, Gertjan L. Kaspers, Hein te Riele, Jacqueline Cloos, Josephine C. Dorsman
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 660-670 (2015)
Background: Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN amplification (RB1+/+MYCNA). There are controversies concerning the existence of molecular subtypes within RB1−/− retinoblastoma. To test whether these molecula
Externí odkaz:
https://doaj.org/article/db54bfbc068f4183bfb31b53cfcb3035