Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Hein, Te Riele"'
Autor:
Govind Pai, Khashayar Roohollahi, Davy Rockx, Yvonne de Jong, Chantal Stoepker, Charlotte Pennings, Martin Rooimans, Lianne Vriend, Sander Piersma, Connie R. Jimenez, Renee X. De Menezes, Victor W. Van Beusechem, Ruud H. Brakenhoff, Hein Te Riele, Rob M. F. Wolthuis, Josephine C. Dorsman
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
A genome-wide siRNA screen on patient-derived Fanconi anemia pathway-deficient head-and-neck squamous-cell-carcinoma (HNSCC) cell lines identifies RBBP9 as a candidate therapeutic target.
Externí odkaz:
https://doaj.org/article/d4abaadf82fc4ce89a966aaa06a906bf
Autor:
Tim J. W. Harmsen, Colin E. J. Pritchard, Joey Riepsaame, Henri J. van de Vrugt, Ivo J. Huijbers, Hein te Riele
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Promiscuous activity of the Streptococcus pyogenes DNA nuclease CRISPR-Cas9 can result in destruction of a successfully modified sequence obtained by templated repair of a Cas9-induced DNA double-strand break. To avoid re-cutting, additional
Externí odkaz:
https://doaj.org/article/5a302beab37f4b3db70dfe7a0b5f39e5
Autor:
Wietske Pieters, Floor Hugenholtz, Kevin Kos, Maxime Cammeraat, Teddy C. Moliej, Daphne Kaldenbach, Sjoerd Klarenbeek, Mark Davids, Lisa Drost, Charlotte de Konink, Elly Delzenne-Goette, Karin E. de Visser, Hein te Riele
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The gut microbiota strongly impacts the development of sporadic colorectal cancer (CRC), but it is largely unknown how the microbiota affects the pathogenesis of mismatch-repair-deficient CRC in the context of Lynch syndrome. In a mouse model for Lyn
Externí odkaz:
https://doaj.org/article/ea7cde7a89e14a07858878eb822c53b1
Autor:
Yuchen Guo, Jun Wang, Bente Benedict, Chen Yang, Frank van Gemert, Xuhui Ma, Dongmei Gao, Hui Wang, Shu Zhang, Cor Lieftink, Roderick L. Beijersbergen, Hein te Riele, Xiaohang Qiao, Qiang Gao, Chong Sun, Wenxin Qin, René Bernards, Cun Wang
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract Background Liver cancer is one of the most commonly diagnosed cancers and the fourth leading cause of cancer-related death worldwide. Broad-spectrum kinase inhibitors like sorafenib and lenvatinib provide only modest survival benefit to pati
Externí odkaz:
https://doaj.org/article/d3b40c6ab0ea4445955311ad736bc6e4
Autor:
Janne J. M. van Schie, Atiq Faramarz, Jesper A. Balk, Grant S. Stewart, Erika Cantelli, Anneke B. Oostra, Martin A. Rooimans, Joanna L. Parish, Cynthia de Almeida Estéves, Katja Dumic, Ingeborg Barisic, Karin E. M. Diderich, Marjon A. van Slegtenhorst, Mohammad Mahtab, Francesca M. Pisani, Hein te Riele, Najim Ameziane, Rob M. F. Wolthuis, Job de Lange
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
WABS patient derived cells display loss of sister chromatid cohesion. Here the authors by analyzing WABS patient derived cells, reveal a role of the DDX11 helicase in resolving G-Quadruplex structures to support sister chromatid cohesion.
Externí odkaz:
https://doaj.org/article/d1dd653aad8b4232927aa9fceeb46e31
Autor:
Susanne R Bruekner, Wietske Pieters, Alexander Fish, A Manuel Liaci, Serge Scheffers, Emily Rayner, Daphne Kaldenbach, Lisa Drost, Marleen Dekker, Sandrine van Hees-Stuivenberg, Elly Delzenne-Goette, Charlotte de Konink, Hellen Houlleberghs, Hendrikus Jan Dubbink, Abeer AlSaegh, Niels de Wind, Friedrich Förster, Hein te Riele, Titia K Sixma
Publikováno v:
Nucleic Acids Research, 51(3), 1173-1188. Oxford University Press
Bruekner, S R, Pieters, W, Fish, A, Liaci, A M, Scheffers, S, Rayner, E, Kaldenbach, D, Drost, L, Dekker, M, van Hees-Stuivenberg, S, Delzenne-Goette, E, de Konink, C, Houlleberghs, H, Dubbink, H J, Alsaegh, A, de Wind, N, Förster, F, te Riele, H & Sixma, T K 2023, ' Unexpected moves : a conformational change in MutSα enables high-affinity DNA mismatch binding ', Nucleic Acids Research, vol. 51, no. 3, pp. 1173-1188 . https://doi.org/10.1093/nar/gkad015
Bruekner, S R, Pieters, W, Fish, A, Liaci, A M, Scheffers, S, Rayner, E, Kaldenbach, D, Drost, L, Dekker, M, van Hees-Stuivenberg, S, Delzenne-Goette, E, de Konink, C, Houlleberghs, H, Dubbink, H J, Alsaegh, A, de Wind, N, Förster, F, te Riele, H & Sixma, T K 2023, ' Unexpected moves : a conformational change in MutSα enables high-affinity DNA mismatch binding ', Nucleic Acids Research, vol. 51, no. 3, pp. 1173-1188 . https://doi.org/10.1093/nar/gkad015
The DNA mismatch repair protein MutSα recognizes wrongly incorporated DNA bases and initiates their correction during DNA replication. Dysfunctions in mismatch repair lead to a predisposition to cancer. Here, we study the homozygous mutation V63E in
Autor:
Luiza S. E. P. Will Castro, Wietske Pieters, Mir Farshid Alemdehy, Muhammad A. Aslam, Olimpia Alessandra Buoninfante, Jonne A. Raaijmakers, Bas Pilzecker, Paul C. M. van den Berk, Hein te Riele, René H. Medema, Rozangela C. Pedrosa, Heinz Jacobs
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The antihelmintic drug ABZ and its metabolites belong to the chemical family of benzimidazoles (BZM) that act as potent tubulin polymerization inhibitors, suggesting a potential re-direction of BZMs for cancer therapy. Applying UV-Vis spectrometry we
Externí odkaz:
https://doaj.org/article/9e76e3ae24f2402f8606460ae34df061
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009041 (2020)
Through transfection of short single-stranded oligodeoxyribonucleotides (ssODNs) small genomic alterations can be introduced into mammalian cells with high precision. ssODNs integrate into the genome during DNA replication, but the resulting heterodu
Externí odkaz:
https://doaj.org/article/6eb274cca1854357a90cfb1c141016cf
Autor:
Adrian C. Begg, Marcel Verheij, Michiel W.M. van den Brekel, Hein te Riele, Ron Kerkhoven, Lodewyk F. Wessels, Reidar Grénman, Jelle J. ten Hoeve, Monique C. de Jong
Supplementary Figure 1 and Tables 1-8. Supplementary figure 1. Heatmap of common response, 2 and 6 hours after irradiation. Heatmap of the common response to 4 Gy irradiation in all 32 cell lines, adapted from the BRB-array tools time course plug-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c75d76e59327c9a6632145004d999f
https://doi.org/10.1158/1078-0432.22460798.v1
https://doi.org/10.1158/1078-0432.22460798.v1
Autor:
Adrian C. Begg, Marcel Verheij, Michiel W.M. van den Brekel, Hein te Riele, Ron Kerkhoven, Lodewyk F. Wessels, Reidar Grénman, Jelle J. ten Hoeve, Monique C. de Jong
Supplementary Information. This file contains a text file with the interactions between miRs and mRNAs used for the analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86459a1a7fd7e7b93db1cf1973b48578
https://doi.org/10.1158/1078-0432.22460795
https://doi.org/10.1158/1078-0432.22460795