Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Hein, Schepers"'
Autor:
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink
Publikováno v:
eLife, Vol 11 (2022)
A loss of the checkpoint kinase ataxia telangiectasia mutated (ATM) leads to impairments in the DNA damage response, and in humans causes cerebellar neurodegeneration, and an increased risk of cancer. A loss of ATM is also associated with increased p
Externí odkaz:
https://doaj.org/article/856b7f3066a9420b8c72ca00c91ef1e2
CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases
Autor:
Roald A Lambrechts, Hein Schepers, Yi Yu, Marianne van der Zwaag, Kaija J Autio, Marcel A Vieira‐Lara, Barbara M Bakker, Marina A Tijssen, Susan J Hayflick, Nicola A Grzeschik, Ody CM Sibon
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-21 (2019)
Abstract PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defect
Externí odkaz:
https://doaj.org/article/d8554242c8ae4af6849ce730ce21786d
Autor:
Gerbrig Berger, Mylene Gerritsen, Guoqiang Yi, Theresia N. Koorenhof-Scheele, Leonie I. Kroeze, Marian Stevens-Kroef, Kenichi Yoshida, Yuichi Shiraishi, Eva van den Berg, Hein Schepers, Geert Huls, André B. Mulder, Seishi Ogawa, Joost H.A. Martens, Joop H. Jansen, Edo Vellenga
Publikováno v:
Blood Advances, Vol 3, Iss 20, Pp 3111-3122 (2019)
Abstract: Ring sideroblasts (RS) emerge as result of aberrant erythroid differentiation leading to excessive mitochondrial iron accumulation, a characteristic feature for myelodysplastic syndromes (MDS) with mutations in the spliceosome gene SF3B1. H
Externí odkaz:
https://doaj.org/article/fdda625962e64cb881226474942522a5
Autor:
Johannes Jung, Sonja C. Buisman, Ellen Weersing, Albertina Dethmers-Ausema, Erik Zwart, Hein Schepers, Mike R. Dekker, Seka S. Lazare, Franziska Hammerl, Yulia Skokova, Susanne M. Kooistra, Karin Klauke, Raymond A. Poot, Leonid V. Bystrykh, Gerald de Haan
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1906-1918.e8 (2019)
Summary: In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem and progenitor cells (HSPCs). Xenotransplantation of CBX7-overexpressing HSPCs resu
Externí odkaz:
https://doaj.org/article/8e9f30d38fc142b58e0349be1f6e3dd2
Autor:
Wouter Huiting, Suzanne L Dekker, Joris CJ van der Lienden, Rafaella Mergener, Maiara K Musskopf, Gabriel V Furtado, Emma Gerrits, David Coit, Mehrnoosh Oghbaie, Luciano H Di Stefano, Hein Schepers, Maria AWH van Waarde-Verhagen, Suzanne Couzijn, Lara Barazzuol, John LaCava, Harm H Kampinga, Steven Bergink
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cfbbb602cb41ecf8347011b9f6e6e3c
https://doi.org/10.7554/elife.70726.sa2
https://doi.org/10.7554/elife.70726.sa2
Autor:
Cecilia Rocchi, Davide Cinat, Paola Serrano Martinez, Anne L. Jellema-de Bruin, Mirjam Baanstra, Uilke Brouwer, Cinthya del Angel Zuivre, Hein Schepers, Ronald van Os, Lara Barazzuol, Robert P. Coppes
Publikováno v:
Science signaling, 14(712):0599. AMER ASSOC ADVANCEMENT SCIENCE
Salivary glands are damaged by radiotherapy for head and neck cancers, which often culminates in radiation-induced hyposalivation and xerostomia that may be permanent. Here, we identified a central role for YAP in the regenerative response of the sal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c8a2964d2dced3a5d44e5bfe886675
https://doi.org/10.1126/scisignal.abk0599
https://doi.org/10.1126/scisignal.abk0599
Autor:
Karin Klauke, Ellen Weersing, Sonja Buisman, Hein Schepers, Leonid Bystrykh, Seka Lazare, Gerald de Haan, Yulia Skokova, Albertina Dethmers-Ausema, Erik Zwart, Raymond A. Poot, Johannes Jung, Mike R. Dekker, Franziska Hammerl, Susanne M. Kooistra
Publikováno v:
Cell Reports, Vol 26, Iss 7, Pp 1906-1918.e8 (2019)
Cell reports, 26(7), 1906-1918.e8. CELL PRESS
Cell Reports, 26(7), 1906-+. Cell Press
Cell reports, 26(7), 1906-1918.e8. CELL PRESS
Cell Reports, 26(7), 1906-+. Cell Press
Summary: In this study, we demonstrate that, among all five CBX Polycomb proteins, only CBX7 possesses the ability to control self-renewal of human hematopoietic stem and progenitor cells (HSPCs). Xenotransplantation of CBX7-overexpressing HSPCs resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01cfd2860bb29c14a5610f60b79aaf5
http://www.sciencedirect.com/science/article/pii/S2211124719300683
http://www.sciencedirect.com/science/article/pii/S2211124719300683
Autor:
Yi Yu, Marianne van der Zwaag, Jouke Jan Wedman, Hjalmar Permentier, Niels Plomp, Xiu Jia, Bart Kanon, Ellie Eggens-Meijer, Girbe Buist, Hermie Harmsen, Jan Kok, Joana Falcao Salles, Bregje Wertheim, Susan J. Hayflick, Erick Strauss, Nicola A. Grzeschik, Hein Schepers, Ody C.M. Sibon
Publikováno v:
Molecular Cell, 82(14), 2650-2665.e12. CELL PRESS
Coenzyme A (CoA) is essential for metabolism and protein acetylation. Current knowledge holds that each cell obtains CoA exclusively through biosynthesis via the canonical five-step pathway, starting with pantothenate uptake. However, recent studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7ec084a0bf3991b61f83dbe3079515
http://www.scopus.com/inward/record.url?scp=85134782381&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85134782381&partnerID=8YFLogxK
Publikováno v:
Biochimica et Biophysica Acta - Molecular Cell Research. 1868(4)
Coenzyme A (CoA) is a key molecule in cellular metabolism including the tricarboxylic acid cycle, fatty acid synthesis, amino acid synthesis and lipid metabolism. Moreover, CoA is required for biological processes like protein post-translational modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76da075217881da9131341e2fd9c4fbf
https://hdl.handle.net/11370/c3d193b1-5191-4037-8200-a0c1ae60d50a
https://hdl.handle.net/11370/c3d193b1-5191-4037-8200-a0c1ae60d50a
CoA-dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases
Autor:
Barbara M. Bakker, Kaija J. Autio, Susan J. Hayflick, Nicola A. Grzeschik, Marianne van der Zwaag, Yi Yu, Marina A. J. Tijssen, Hein Schepers, Roald A. Lambrechts, Ody C. M. Sibon, Marcel A. Vieira-Lara
Publikováno v:
EMBO Molecular Medicine. Wiley
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
PKAN, CoPAN, MePAN, and PDH‐E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3574b44d433217f81f982f602fce1f28
https://research.rug.nl/en/publications/1bc8c5d5-b8d0-4d70-8ba5-923d8a98267b
https://research.rug.nl/en/publications/1bc8c5d5-b8d0-4d70-8ba5-923d8a98267b