Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Heimo Syvala"'
Autor:
Reetta Nätkin, Pasi Pennanen, Heimo Syvälä, Merja Bläuer, Juha Kesseli, Teuvo L J Tammela, Matti Nykter, Teemu J Murtola
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281645 (2023)
Androgen deprivation therapy is the cornerstone treatment of advanced prostate cancer. Eventually prostate cancer cells overcome androgen deprivation therapy, giving rise to castration resistant prostate cancer (CRPC) characterized by increased andro
Externí odkaz:
https://doaj.org/article/9203e67f881845b9a88f84cbfa676d4a
Autor:
Paavo Raittinen, Kati Niemistö, Erika Pennanen, Heimo Syvälä, Seppo Auriola, Jarno Riikonen, Terho Lehtimäki, Pauliina Ilmonen, Teemu Murtola
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Prostate cancer patients using cholesterol-lowering statins have 30% lower risk of prostate cancer death compared to non-users. The effect is attributed to the inhibition of the mevalonate pathway in prostate cancer cells. Moreover, statin u
Externí odkaz:
https://doaj.org/article/25b99540e9c54e4abc8a9297592afb94
Autor:
Paavo V.H. Raittinen, Heimo Syvälä, Teuvo L.J. Tammela, Merja R. Häkkinen, Pauliina Ilmonen, Seppo Auriola, Teemu J. Murtola
Publikováno v:
EBioMedicine, Vol 68, Iss , Pp 103432- (2021)
Background: Prostate cancer (PCa) progression depends on androgen receptor activity. Cholesterol is required for biosynthesis of all steroid hormones, including androgens. Impact of cholesterol-lowering statins on androgens is unknown. We explored at
Externí odkaz:
https://doaj.org/article/7bff6d903e364fed937b94edbc772cf2
Autor:
Teemu J Murtola, Heimo Syvälä, Pasi Pennanen, Merja Bläuer, Tiina Solakivi, Timo Ylikomi, Teuvo L J Tammela
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39445 (2012)
Cholesterol-lowering treatment has been suggested to delay progression of prostate cancer by decreasing serum LDL. We studied in vitro the effect of extracellular LDL-cholesterol on the number of prostate epithelial cells and on the expression of key
Externí odkaz:
https://doaj.org/article/a8729a04aba042b29caa24e45271cc4e
Autor:
Terho Lehtimäki, Antti Kaipia, Teemu Tolonen, Heimo Syvala, Seppo Auriola, Teemu J. Murtola, Juha Koskimaki, Emma Raitoharju, Teuvo Tammela, Paula Kujala, Jarno Riikonen
Publikováno v:
Cancer Prevention Research. 5:B69-B69
Background: A widely used group of cholesterol-lowering drugs, statins, have shown promise in prostate cancer prevention. Statin treatment inhibits growth of prostate cancer cells. Statin users have decreased risk of advanced prostate cancer and poss