A blueprint for pursuing therapeutic interventions and early phase clinical trials in clonal haematopoiesis.

Autor: Haque T; Department of Medicine, Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Shastri A; Division of Hematologic Malignancies, Department of Oncology, Montefiore-Einstein Comprehensive Cancer Center, Bronx, New York, USA., Desai P; Department of Medicine, Hematology/Oncology, Cornell University, New York, New York, USA., Xie Z; Malignant Hematology Department, Moffit Cancer Center, Tampa, Florida, USA., Hammond D; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas, USA., King Z; Division of Hematologic Malignancies, Department of Oncology, Montefiore-Einstein Comprehensive Cancer Center, Bronx, New York, USA., Kishtagari A; Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA., Madanat YF; Division of Hematology and Oncology, UT Southwestern, Dallas, Texas, USA., Abaza Y; Department of Medicine, Hematology and Oncology, Northwestern University, Chicago, Illinois, USA., Silver AJ; Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA., Singh A; Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, Ohio, USA., Borate UM; Division of Hematology, Department of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA., Heimlich JB; Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA., Slosky DA; Division of Cardiology, Department of Medicine, University of Wisconsin Medical Center, Madison, Wisconsin, USA., Bolton KL; Division of Oncology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA., Patnaik MS; Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA., Bick AG; Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA., Verma AK; Division of Hematologic Malignancies, Department of Oncology, Montefiore-Einstein Comprehensive Cancer Center, Bronx, New York, USA., Jaiswal S; Department of Pathology, Stanford University, Stanford, California, USA., Steensma DP; DP Steensma LLC, Cambridge, Massachusetts, USA., Savona MR; Department of Medicine, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, USA.

Publikováno v: British journal of haematology [Br J Haematol] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.

Germline genetics, disease, and exposure to medication influence longitudinal dynamics of clonal hematopoiesis.

Autor: Mack T; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN., Pershad Y; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN., Vlasschaert C; Department of Medicine, Queen's University, Kingston, Ontario., Bejan CA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN., Heimlich JB; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Li Y; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., Mickels NA; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN., Van Amburg JC; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN., Ulloa J; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN., Silver AJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN., Luo LY; Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN., Jones A; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN., Ferrell PB; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Kishtagari A; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN., Xu Y; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN., Savona MR; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN, USA; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA; Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN., Bick AG; Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. alexander.bick@vumc.org.

Publikováno v: Haematologica [Haematologica] 2024 Nov 14. Date of Electronic Publication: 2024 Nov 14.

Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation.

Autor: Heimlich JB; Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Bhat P; Vanderbilt University School of Medicine, Nashville, TN., Parker AC; Vanderbilt University School of Medicine, Nashville, TN., Jenkins MT; Vanderbilt University School of Medicine, Nashville, TN., Vlasschaert C; Department of Medicine, Queen's University, Kingston, ON, Canada., Ulloa J; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Van Amburg JC; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Potts CR; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Olson S; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Silver AJ; Vanderbilt University School of Medicine, Nashville, TN., Ahmad A; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Sharber B; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Brown D; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Hu N; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., van Galen P; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA., Savona MR; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Program in Cancer Biology, and Center for Immunobiology, Nashville, TN.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN., Bick AG; Division of Genomic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Ferrell PB; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.

Publikováno v: Blood advances [Blood Adv] 2024 Jul 23; Vol. 8 (14), pp. 3665-3678.

Cost-Effective and Scalable Clonal Hematopoiesis Assay Provides Insight into Clonal Dynamics.

Autor: Mack T; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Vlasschaert C; Department of Medicine, Queen's University, Kingston, Ontario, Canada., von Beck K; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Silver AJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee., Heimlich JB; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Poisner H; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Condon HR; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Ulloa J; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Sochacki AL; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Spaulding TP; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Kishtagari A; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Bejan CA; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee., Xu Y; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee., Savona MR; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee; Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee; Center for Immunobiology, Vanderbilt University Medical Center, Nashville, Tennessee., Jones A; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee., Bick AG; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, Tennessee; Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Electronic address: alexander.bick@vumc.org.

Publikováno v: The Journal of molecular diagnostics : JMD [J Mol Diagn] 2024 Jul; Vol. 26 (7), pp. 563-573. Date of Electronic Publication: 2024 Apr 06.

Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk.

Autor: Yu Z; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Fidler TP; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Ruan Y; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Vlasschaert C; Department of Medicine, Queen's University, Kingston, Ontario, Canada., Nakao T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Uddin MM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA., Mack T; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Niroula A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden., Heimlich JB; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Zekavat SM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Ophthalmology, Massachusetts Eye and Ear Institute, Boston, Massachusetts, USA., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Griffin GK; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA., Wang Y; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA., Heard-Costa N; Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA., Levy D; Framingham Heart Study, Framingham, Massachusetts, USA.; Division of Intramural Research, National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, Maryland, USA., Vasan RS; Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA.; Framingham Heart Study, Framingham, Massachusetts, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA., Aguet F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA., Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA., Libby P; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Jaiswal S; Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA., Ebert BL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Bick AG; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Tall AR; Division of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Sep 15; Vol. 133 (18). Date of Electronic Publication: 2023 Sep 15.