Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Autor: Muus, C, Luecken, MD, Eraslan, G, Sikkema, L, Waghray, A, Heimberg, G, Kobayashi, Y, Vaishnav, ED, Subramanian, A, Smillie, C, Jagadeesh, KA, Duong, ET, Fiskin, E, Triglia, ET, Ansari, M, Cai, P, Lin, B, Buchanan, J, Chen, S, Shu, J, Haber, AL, Chung, H, Montoro, DT, Adams, T, Aliee, H, Allon, SJ, Andrusivova, Z, Angelidis, I, Ashenberg, O, Bassler, K, Bécavin, C, Benhar, I, Bergenstråhle, J, Bergenstråhle, L, Bolt, L, Braun, E, Bui, LT, Callori, S, Chaffin, M, Chichelnitskiy, E, Chiou, J, Conlon, TM, Cuoco, MS, Cuomo, ASE, Deprez, M, Duclos, G, Fine, D, Fischer, DS, Ghazanfar, S, Gillich, A, Giotti, B, Gould, J, Guo, M, Gutierrez, AJ, Habermann, AC, Harvey, T, He, P, Hou, X, Hu, L, Hu, Y, Jaiswal, A, Ji, L, Jiang, P, Kapellos, TS, Kuo, CS, Larsson, L, Leney-Greene, MA, Lim, K, Litviňuková, M, Ludwig, LS, Lukassen, S, Luo, W, Maatz, H, Madissoon, E, Mamanova, L, Manakongtreecheep, K, Leroy, S, Mayr, CH, Mbano, IM, McAdams, AM, Nabhan, AN, Nyquist, SK, Penland, L, Poirion, OB, Poli, S, Qi, C, Queen, R, Reichart, D, Rosas, I, Schupp, JC, Shea, CV, Shi, X, Sinha, R, Sit, RV, Slowikowski, K, Slyper, M, Smith, NP, Sountoulidis, A, Strunz, M, Sullivan, TB, Sun, D, Talavera-López, C, Tan, P, Tantivit, J, Travaglini, KJ, Tucker, NR, Vernon, KA, Wadsworth, MH, Waldman, J, Wang, X, Xu, K, Yan, W, Zhao, W, Ziegler, CGK, NHLBI LungMap Consortium, Human Cell Atlas Lung Biological Network

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::b0bcc85331e84b5df1d0e1898c3be63e
https://hdl.handle.net/10453/152907

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A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.

Autor: Delorey TM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Ziegler CGK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA 02115, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA., Heimberg G; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Normand R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA.; Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Yang Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Segerstolpe A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Abbondanza D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Fleming SJ; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Subramanian A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Montoro DT; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jagadeesh KA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Dey KK; Department of Epidemiology, Harvard School of Public Health., Sen P; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Pita-Juárez YH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Phillips D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Bloom-Ackerman Z; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Barkas N; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Ganna A; Institute for Molecular Medicine Finland, Helsinki, Finland.; Analytical & Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Gomez J; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Normandin E; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA., Naderi P; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA., Popov YV; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Raju SS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.; FAS Center for Systems Biology, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA., Niezen S; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Tsai LT; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115.; Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, MA 02115, USA., Siddle KJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA., Sud M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Tran VM; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vellarikkal SK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Amir-Zilberstein L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Atri DS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Beechem J; NanoString Technologies Inc., Seattle, WA 98109, USA., Brook OR; Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Chen J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Divakar P; NanoString Technologies Inc., Seattle, WA 98109, USA., Dorceus P; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Engreitz JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics and BASE Initiative, Stanford University School of Medicine., Essene A; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115.; Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, MA 02115, USA., Fitzgerald DM; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Fropf R; NanoString Technologies Inc., Seattle, WA 98109, USA., Gazal S; Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Gould J; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Grzyb J; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115., Harvey T; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Hecht J; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Hether T; NanoString Technologies Inc., Seattle, WA 98109, USA., Jane-Valbuena J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Leney-Greene M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ma H; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., McCabe C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., McLoughlin DE; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Miller EM; NanoString Technologies Inc., Seattle, WA 98109, USA., Muus C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138., Niemi M; Institute for Molecular Medicine Finland, Helsinki, Finland., Padera R; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.; Harvard-MIT Division of Health Sciences and Technology, Cambridge MA.; Department of Pathology, Harvard Medical School, Boston, MA 02115, USA., Pan L; NanoString Technologies Inc., Seattle, WA 98109, USA., Pant D; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02115.; Boston Nutrition and Obesity Research Center Functional Genomics and Bioinformatics Core Boston, MA 02115, USA., Pe'er C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Pfiffner-Borges J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pinto CJ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Plaisted J; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115., Reeves J; NanoString Technologies Inc., Seattle, WA 98109, USA., Ross M; NanoString Technologies Inc., Seattle, WA 98109, USA., Rudy M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rueckert EH; NanoString Technologies Inc., Seattle, WA 98109, USA., Siciliano M; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115., Sturm A; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Todres E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Waghray A; Harvard Stem Cell Institute, Cambridge, MA, USA.; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Warren S; NanoString Technologies Inc., Seattle, WA 98109, USA., Zhang S; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zollinger DR; NanoString Technologies Inc., Seattle, WA 98109, USA., Cosimi L; Infectious Diseases Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gupta RM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Divisions of Cardiovascular Medicine and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Hacohen N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Hide W; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Price AL; Department of Epidemiology, Harvard School of Public Health., Rajagopal J; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Tata PR; Duke University School of Medicine, Durham, NC., Riedel S; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Szabo G; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA., Tickle TL; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142., Hung D; Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.; Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA., Novak R; Wyss Institute for Biologically Inspired Engineering, Harvard University., Rogers R; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Massachusetts General Hospital, MA 02114, USA., Ingber DE; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138.; Wyss Institute for Biologically Inspired Engineering, Harvard University.; Vascular Biology Program and Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA USA., Jiang ZG; Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, MA 02115, USA.; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Juric D; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Babadi M; Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142.; Precision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Farhi SL; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Stone JR; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Vlachos IS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Harvard Medical School, Boston, MA 02115, USA.; Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.; Harvard Medical School Initiative for RNA Medicine, Boston, MA 02115, USA.; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA., Solomon IH; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115., Ashenberg O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Porter CBM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA., Li B; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Program in Health Sciences & Technology, Harvard Medical School & Massachusetts Institute of Technology, Boston, MA 02115, USA.; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.; Harvard Graduate Program in Biophysics, Harvard University, Cambridge, MA 02138, USA.; Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Program in Computational & Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Villani AC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.; Current address: Genentech, 1 DNA Way, South San Francisco, CA, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Current address: Genentech, 1 DNA Way, South San Francisco, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Feb 25. Date of Electronic Publication: 2021 Feb 25.