Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Heiko Zettl"'
Publikováno v:
Energies, Vol 11, Iss 4, p 999 (2018)
A new type of high-temperature stable and self-supporting composite separator for lithium-ion batteries was developed consisting of custom-made ultrathin micrometer-sized glass platelets embedded in a glass fiber nonwoven together with a water-based
Externí odkaz:
https://doaj.org/article/2cd4af3ae993439c8d8d3afc3539778e
Autor:
Markus Hartenfeller, Heiko Zettl, Miriam Walter, Matthias Rupp, Felix Reisen, Ewgenij Proschak, Sascha Weggen, Holger Stark, Gisbert Schneider
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 2, p e1002380 (2012)
We present a computational method for the reaction-based de novo design of drug-like molecules. The software DOGS (Design of Genuine Structures) features a ligand-based strategy for automated 'in silico' assembly of potentially novel bioactive compou
Externí odkaz:
https://doaj.org/article/f1f6a52b4df74591a77f20b65aa75316
Autor:
Mario Wurglics, Mark N. Wass, Heiko Zettl, Manfred Schubert-Zsilavecz, Michaela Dittrich, Taravat Ghafourian, Jindrich Cinatl, Florian Rothweiler, Michael Wiese, Martin Michaelis, Natália Aniceto
Publikováno v:
Oncotarget
Pirinixic acid derivatives, a new class of drug candidates for a range of diseases, interfere with targets including PPARα, PPARγ, 5-lipoxygenase (5-LO), and microsomal prostaglandin and E2 synthase-1 (mPGES1). Since 5-LO, mPGES1, PPARα, and
Publikováno v:
Energies; Volume 11; Issue 4; Pages: 999
A new type of high-temperature stable and self-supporting composite separator for lithium-ion batteries was developed consisting of custom-made ultrathin micrometer-sized glass platelets embedded in a glass fiber nonwoven together with a water-based
Publikováno v:
Journal of Biological Chemistry. 288:28347-28356
Mitogen-activated protein kinases (MAPKs) fulfill essential biological functions and are key pharmaceutical targets. Regulation of MAPKs is achieved via a plethora of regulatory proteins including activating MAPKKs and an abundance of deactivating ph
Autor:
Tiago Rodrigues, Christian P. Koch, Michael Reutlinger, Gisbert Schneider, Birgit Spänkuch, Petra Schneider, Heiko Zettl, Lisa Lange, Sarah Keppner, Markus Hartenfeller
Publikováno v:
Angewandte Chemie. 125:4774-4779
Autor:
Oliver Werz, Sascha Weggen, Martina Hieke, Ramona Steri, Manfred Schubert-Zsilavecz, Heiko Zettl, Christine Greiner, Julia Ness
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5372-5382
A novel set of dual γ-secretase/PPARγ modulators characterized by a 2-benzyl hexanoic acid scaffold is presented. Synthetic efforts were focused on the variation of the substitution pattern of the central benzene. Finally, we obtained a new class o
Autor:
Christine Greiner, Oliver Werz, Carlo Pergola, Hinnak Northoff, Manfred Schubert-Zsilavecz, Andreas Koeberle, Heiko Zettl
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:3394-3401
5-Lipoxygenase (5-LO) and microsomal prostaglandin E₂ synthase (mPGES)-1 are key enzymes in the biosynthesis of leukotrienes and prostaglandin (PG)E₂, respectively, and are considered as valuable targets for the treatment of inflammatory diseases
Autor:
Martina Hieke, Christine Greiner, Theresa M. Thieme, Heiko Zettl, Manfred Schubert-Zsilavecz, Oliver Werz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1329-1333
Dual inhibition of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO) represents a promising strategy in the development of novel anti-inflammatory drugs targeting the arachidonic acid cascade. Herein, a class of α-naphthyl p
Autor:
Michael Reutlinger, Markus Hartenfeller, Jan A. Hiss, Birgit Spänkuch, Heiko Zettl, Sarah Keppner, Felix Reisen, Gisbert Schneider, Tim Geppert, Petra Schneider, Alexander Klenner, Volker Hähnke
Publikováno v:
Future Medicinal Chemistry. 3:415-424
Background: De novo design of drug-like compounds with a desired pharmacological activity profile has become feasible through innovative computer algorithms. Fragment-based design and simulated chemical reactions allow for the rapid generation of can