Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase

Autor: Sabrina Patzelt, Manuela Pigors, Heiko Steenbock, Leonard Diel, Katharina Boch, Lenche Chakievska, Sven Künzel, Hauke Busch, Anke Fähnrich, Jürgen Brinckmann, Enno Schmidt

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the basal membrane zone of skin and surface-close epithelia and predominant mucosal lesions. The oral cavity and conjunctivae are most freque

Externí odkaz: https://doaj.org/article/5ee49a04b8984752b1c93fef3932668a

Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome

Autor: Salome M. Brütsch, Elizabeta Madzharova, Sophia Pantasis, Till Wüstemann, Selina Gurri, Heiko Steenbock, Amiq Gazdhar, Gisela Kuhn, Peter Angel, Saverio Bellusci, Jürgen Brinckmann, Ulrich auf dem Keller, Sabine Werner, Mattia R. Bordoli

Publikováno v: Brütsch, S M, Madzharova, E, Pantasis, S, Wüstemann, T, Gurri, S, Steenbock, H, Gazdhar, A, Kuhn, G, Angel, P, Bellusci, S, Brinckmann, J, auf dem Keller, U, Werner, S & Bordoli, M R 2023, ' Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome ', Cellular and Molecular Life Sciences, vol. 80, no. 4, 89 . https://doi.org/10.1007/s00018-023-04735-6
Brütsch, Salome M; Madzharova, Elizabeta; Pantasis, Sophia; Wüstemann, Till; Gurri, Selina; Steenbock, Heiko; Gazdhar, Amiq; Kuhn, Gisela; Angel, Peter; Bellusci, Saverio; Brinckmann, Jürgen; Auf dem Keller, Ulrich; Werner, Sabine; Bordoli, Mattia R (2023). Mesenchyme-derived vertebrate lonesome kinase controls lung organogenesis by altering the matrisome. Cellular and molecular life sciences : CMLS, 80(4), p. 89. Springer 10.1007/s00018-023-04735-6
Cellular and Molecular Life Sciences, 80 (4)

Vertebrate lonesome kinase (VLK) is the only known secreted tyrosine kinase and responsible for the phosphorylation of a broad range of secretory pathway-resident and extracellular matrix proteins. However, its cell-type specific functions in vivo ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e887d224134568655fa90513e229f687
https://orbit.dtu.dk/en/publications/dbe7c0dd-3549-4535-ae10-3a6996507604

Minoxidil Cannot Be Used To Target Lysyl Hydroxylases during Postnatal Mouse Lung Development: A Cautionary Note

Autor: Ivana Mižíková, Jürgen Brinckmann, Tilman Pfeffer, István Vadász, Rory E. Morty, Heiko Steenbock, Hajime Inoue, Despoina Myti, David E. Surate Solaligue, Ettore Lignelli, Werner Seeger, Susanne Herold

Publikováno v: The Journal of pharmacology and experimental therapeutics. 375(3)

The lysyl hydroxylases (procollagen-lysine 5-dioxygenases) PLOD1, PLOD2, and PLOD3 have been proposed as pathogenic mediators of stunted lung development in bronchopulmonary dysplasia (BPD), a common complication of preterm birth. In affected infants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5afcbf2ba83aa1be18e80d3e9ca578e
https://pubmed.ncbi.nlm.nih.gov/33020194

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

Autor: Jürgen Brinckmann, Michael Cangkrama, Serena Grossi, Dimitris Kletsas, Jörn Dengjel, Paul Hiebert, Mateusz S. Wietecha, Heiko Steenbock, Hans-Dietmar Beer, Eric Haertel, Michael Stumpe, Eleni Mavrogonatou, Peter Angel, Sabine Werner

Publikováno v: Developmental Cell, 46 (2)

Nrf2 is a key regulator of the antioxidant defense system, and pharmacological Nrf2 activation is a promising strategy for cancer prevention and promotion of tissue repair. Here we show, however, that activation of Nrf2 in fibroblasts induces cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615a345f8d83557cbe78ce36f7a4fbee
https://pubmed.ncbi.nlm.nih.gov/30016619

The Extracellular Matrix Signature in Vein Graft Disease

Autor: Dieter P. Reinhardt, Jürgen Brinckmann, Heiko Steenbock, Claus Bartels, Hans H. Sievers, Claudia Schmidtke, Birgit Kahle, Nicolas Hunzelmann

Publikováno v: Canadian Journal of Cardiology. 32:1008.e11-1008.e17

Background Vein graft disease is a major and yet unsolved problem in cardiac revascularization surgery. Although accumulation of extracellular matrix is characteristic for vein graft disease, detailed analysis of the fibrotic material is lacking. Bec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2613454c5c49f7ff0babc721184fc22b
https://doi.org/10.1016/j.cjca.2015.11.014